Lactams
Medchemexpress LLC Thalidomide-NH-C10-COOH | 2428400-33-1 | 97.5% | 250 MG
Thalidomide-NH-C10-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide based CRBN ligand and a linker used in PROTAC technology. With a molecular weight of 457.52 and formula C24H31N3O6, this compound appears as a light yellow to yellow solid. It is intended for research use only.
- Targets cereblon.
- Recommended storage for powder is -20°C for 3 years or 4°C for 2 years.
- When in solvent, store at -80°C for 6 months or -20°C for 1 month.
- Part of PROTAC technology.
Medchemexpress LLC Thalidomide-4-O-C12-NH2 hydrochloride | 95.6% | 494.02 | C25H36ClN3O5 | 10 MG
Thalidomide-4-O-C12-NH2 hydrochloride is a thalidomide-derived cereblon ligand provided as the hydrochloride salt for use in chemical biology and medicinal chemistry applications. It functions as a CRBN E3 ligase recruiter for targeted protein degradation and is intended for use in PROTAC and ligand-linker conjugation studies. Store protected from light at recommended temperatures.
Medchemexpress LLC Deoxy-thalidomide-5-iodine | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 250 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog used as a cereblon-binding ligand in targeted protein degradation and PROTAC research. It is provided as a characterized small-molecule building block suitable for conjugation in bifunctional degrader synthesis and related chemical biology applications.
- Used as cereblon-binding ligand for PROTAC development.
- High reported purity: 98.0% (NMR).
- Molecular weight 370.14 g/mol and formula C13H11IN2O3.
- Solid; store at 4°C and protect from light.
- Available in multiple package sizes, including 250 mg.
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 10mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 1 G
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is characterized by its high purity of 99.8%.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Designed for use in PROTACs that exploit the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-5-O-C6-NH2 hydrochloride | 2761398-05-2 | 409.86 | C19H24ClN3O5 | 10 MG
Thalidomide-5-O-C6-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC development and chemical biology research. The compound contains a six-carbon linker terminating in a primary amine and is supplied as the hydrochloride salt to aid handling and stability for research applications.
- Used as a cereblon ligand to recruit CRBN in PROTAC and degrader design.
- Contains a C6 linker with a terminal amine for conjugation to linkers or target ligands.
- Provided as a hydrochloride salt for improved handling and solubility.
- Solid form suitable for storage under recommended conditions.
- Intended for research use; consult vendor documentation or COA for purity and analytical data.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | >98.0% | 586.03 | 25 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It integrates a thalidomide-based cereblon ligand with a linker, making it suitable for applications in PROTAC technology. This compound is intended for research purposes only and is not for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology applications
- Suitable for research use
TARGETMOL CHEMICALS INC S-THALIDOMIDE 5MG
Also available in 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory anti-inflammatory anticancer anti-angiogenic and pro-apoptotic activities and is used in the study of leprosy erythema nodosum and myeloma. purity: 99%
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 25 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) are designed with two different ligands connected by a linker, enabling the selective degradation of target proteins.
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology
- Designed for selective degradation of target proteins
- For research use only
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g·mol⁻¹ | C13H11IN2O3 | 1 G
Deoxy-thalidomide-5-iodine is a thalidomide analogue used as an E3 ligase ligand in PROTAC research and cereblon-targeting studies. Supplied as a high-purity solid, it is commonly used as a building block for synthesis of degraders and chemical probes.
- High purity suitable for research (98.0%).
- Chemical formula C13H11IN2O3.
- Molecular weight 370.14 g·mol⁻¹.
- Useful as an E3 ligase (cereblon) ligand in PROTAC design.
- Solid form for ease of handling and storage.
- Store protected from light at refrigerated temperatures; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2h-isoindol-2-yl)- | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 25 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog bearing an iodine substituent at the 5-position used as a cereblon-binding ligand in PROTAC and targeted protein degradation research. Supplied as a colored solid with high reported purity, it is intended for chemical biology and linker-conjugation workflows.
- Thalidomide-derived cereblon ligand suitable for PROTAC design.
- High reported purity (98.0% by NMR) for research applications.
- Blue to blue-green solid physical form for easy handling.
- Molecular formula C13H11IN2O3 and molecular weight 370.14 g/mol.
- Suitable for linker attachment and synthesis of bifunctional degraders.
Medchemexpress LLC S-thalidomide-4-OH | 2357105-36-1 | MFCD03699892 | 98.0% | 274.23 | C13H10N2O5 | 25 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-based cereblon (CRBN) ligand used in chemical biology and proteolysis-targeting chimera (PROTAC) design. Supplied as a high-purity powder, it is intended for research use in CRBN recruitment studies and degrader synthesis.
- High purity (98.0%) for research applications.
- S-enantiomer for stereospecific biochemical studies.
- Useful cereblon ligand for PROTAC conjugation.
- Available in small milligram quantities for screening and synthesis.
- Stable when stored under recommended conditions.
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 10 MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form IMiD containing PROTACs. It is a click chemistry reagent containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can form IMiD containing PROTACs when connected to a ligand for protein by a linker
- Click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 00-00-0 | 95.6% | C23H32ClN3O5 | 10MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand formulated as a hydrochloride salt for use in PROTAC design and related biochemical research. Supplied as a solid with reported high purity, it is intended for small-scale laboratory studies and compound linking applications.
- Hydrochloride salt form for improved stability
- High purity suitable for research applications
- Molecular formula C23H32ClN3O5 and molecular weight 465.97
- Available in small packaging sizes for synthesis and screening
- Solid form for convenient handling and storage
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | ≥95.0% | 433.41 g/mol | C20H23N3O8 | 5 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a short PEG2 carboxylic acid linker. It is designed as a building block for PROTAC (proteolysis targeting chimera) synthesis and related chemical biology research. For research use only.
- Provides CRBN engagement via a thalidomide-derived ligand.
- Contains a PEG2 spacer terminating in a carboxylic acid for linker conjugation.
- Suitable as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Characterized by analytical data, including HPLC, LC-MS, and NMR files.
- Available in small research-scale quantities for medicinal chemistry applications.