Lactams
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.86% | 394.85 | 50 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. For research use only.
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 1 G
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative (5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione) described as an E3 ligase activator. It is provided as a research chemical for use as a biochemical probe, synthetic building block, or starting material for further derivatization.
- Acts as an E3 ligase activator useful in targeted protein degradation studies.
- Contains a fluorine atom enabling SNAr reactions and further derivatization.
- Supplied in small-quantity packages suitable for research and synthesis.
- Well-defined chemical identity with CAS 2230957-36-3.
- Chemical formula C14H11FN2O4 and molecular weight 290.25.
eMolecules 676560-15-9 | Ethyl 4-((tert-butyldimethylsilyl)oxy)cyclohexanecarboxylate | MFCD24038913 | 1g
Ambeed | Ethyl 4-((tert-butyldimethylsilyl)oxy)cyclohexanecarboxylate | 1g | 490561494 | A433149 | 676560-15-9 | MFCD24038913 | 286.487 | C15H30O3Si
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Medchemexpress LLC Thalidomide-NH-C10-NH2 hydrochloride | 2460022-53-9 | 464.99 | C23H33ClN4O4 | 10 MG
Thalidomide-NH-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt in solid form for research use. It is intended for incorporation into PROTACs and other E3 ligase recruiting conjugates for chemical biology and medicinal chemistry studies.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Suitable for PROTAC construction and linker conjugation.
- Provided as a solid hydrochloride salt for stability and handling.
- Available in small milligram packages appropriate for synthesis and assays.
- Store sealed, away from moisture and light; follow supplier storage guidance.
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 100 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
Sigma Aldrich Fine Chemicals Biosciences (+)-Thalidomide >=98% (HPLC), powder | 2614-06-4 | MFCD00210220 | 10MG
(+)-Thalidomide >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 258.23 | 2614-06-4 | MFCD00210220 | 10MG
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 25 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They are utilized to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes PROTAC technology for selective degradation of target proteins
- Exploits the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-PEG5-COOH | 2688100-28-7 | 95.9% | 522.50 | 25 MG
Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only and not for medical, clinical diagnostic, or food use in humans or animals.
- Purity: 95.90%
- Appearance: Oil
- Color: Light yellow to brown
- Solubility: Soluble in DMSO at 50 mg/mL (95.69 mM)
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 50 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Uses a linker in PROTAC technology
- Targets Cereblon
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-4-O-C9-NH2 hydrochloride | >98.0% | 451.94 g/mol | C22H30ClN3O5 | 10 MG
Thalidomide-4-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for use in targeted protein degradation and PROTAC development. Supplied as the hydrochloride salt for conjugation chemistry, the compound is offered for research use and is commonly provided in small milligram quantities for medicinal chemistry and chemical biology applications.
- Acts as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Designed for use in PROTAC and targeted protein degradation research.
- Provided as a hydrochloride salt suitable for conjugation chemistry.
- Reported purity ≥98% according to vendor listings.
- Molecular weight ~451.94 g/mol; formula C22H30ClN3O5.
- Store sealed at -20°C to maintain stability.
Medchemexpress LLC 14-3-3 epsilon protein (human), GST-tagged | >95.0% | 5 UG
Recombinant human 14-3-3 epsilon protein fused to an N-terminal GST tag, expressed in Escherichia coli and supplied at high purity for research use. It is suitable for immunoassays, binding studies, and functional assays investigating 14-3-3-mediated signaling and inflammatory responses.
- Source species: human.
- Expression system: Escherichia coli.
- Tag: N-terminal GST.
- Purity: >95.0% by reducing SDS-PAGE.
- Molecular weight: approximately 55.0-58.0 kDa.
- Available size: 5 μg, suitable for assay use.
- Storage: store at -20 °C; after reconstitution stable at 4 °C for 1 week; aliquot and freeze at -80 °C for long term.
- Reported activity: ED50 = 0.3162 μg/mL in antibody-binding assay.
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 250 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used in PROTAC technology
- For research use only
- Inhibitor
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 100 MG
The product "Thalidomide-O-C6-NHBoc" is an E3 ligase ligand-linker conjugate. It is designed for use in PROTAC technology and incorporates a thalidomide-based cereblon ligand with a linker. It is intended for research use only and has a purity of 95.99%.
Features and benefits:
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Used in PROTAC technology
- Purity of 95.99%
- Available in various quantities for research needs
- Includes data sheet, COA, SDS, and handling instructions
- Soluble in DMSO
- Storage at -20°C (1 month) or -80°C (6 months) in solvent