Lactams
Medchemexpress LLC CD3 epsilon Canine 10ug | 10ug
The CD3 protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses When APC is activated TCR signals transmitted by CD3D CD3E CD3G and CD3Z initiate pathways through ITAM CD3 epsilon Protein Canine (HEK293 Fc) is the recombinant canine-derived CD3 epsilon protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 25MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Incorporates thalidomide-based cereblon ligand.
- Utilizes a linker in PROTAC technology.
- Contains two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase, and the other is for the target protein.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
Medchemexpress LLC Vh 101 phenol-alkylc6-amine dihydrochloride | 2564467-16-7 | 704.72 | 50 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand. This compound is suitable for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Tazobactam | 89786-04-9 | 1 G
Tazobactam (CL-298741) is a potent β-lactamase inhibitor and penicillin antibiotic with antibacterial activity, suitable for pneumonia research.
- Shows bactericidal activity.
- Inhibits bacterial growth in a dose-dependent manner.
- Inhibits various types of β-lactamase activity.
- Decreases the number of bacteria in animal models.
- Allows survival at low doses in animal models.
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.86% | 394.85 | 25 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Purity of 99.86%
- Inhibits Cereblon
- Utilizes PROTAC technology for targeted protein degradation
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 100 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only and not intended for sale to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Utilizes linker used in PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 1 ML
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a target protein ligand via a linker to create PROTACs.
- Cereblon ligand
- Used for recruitment of CRBN protein
- Can be linked to a target protein ligand via a linker to create PROTACs
- For research use only
Medchemexpress LLC Thalidomide-o-amido-c3-peg3-c1-nh2 trifluoroacetate | 1799711-29-7 | MFCD32878273 | 99.1% | C27H35F3N4O11 | 10MG
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that couples a thalidomide-derived cereblon ligand to a three-unit polyethylene glycol linker, designed for PROTAC synthesis and related chemical biology research. The compound is supplied as an off-white to light yellow oil, with molecular formula C27H35F3N4O11, molecular weight 648.58 g·mol⁻¹, and high purity suitable for research.
- Contains a thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Includes a three-unit polyethylene glycol linker to enhance flexibility and solubility.
- Designed for PROTAC design and targeted protein degradation studies.
- High purity (99.1%) for consistent experimental results.
- Characterized molecular properties facilitate reproducible use in research.
- Available in small packaging sizes suitable for laboratory studies.
![Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261970.png-250.jpg)
Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.
- Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
- Thalidomide-based ligand with a six-carbon carboxylic acid linker.
- High purity, 99.3% (reported).
- Soluble ≥100 mg/mL in DMSO.
- Off-white to light yellow solid suitable for synthesis.
- Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
- Storage recommendations provided for powder and solutions to maintain stability.
Medchemexpress LLC Thalidomide-4-O-C7-NH2 hydrochloride | 00-00-0 | 99.8% | C20H26ClN3O5 | 10MG
Thalidomide-4-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate provided as the hydrochloride salt for research use in PROTAC development and E3 ligase recruitment studies. It is supplied as a high-purity, well-characterized reagent suitable for biochemical assays, linker conjugation, and medicinal chemistry workflows.
- High purity (99.8%) suitable for research applications.
- Hydrochloride salt form for consistent handling and storage.
- Characterized molecular formula C20H26ClN3O5 and molecular weight 387.43 g/mol.
- Functions as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
- Available in small, lab-scale quantities for screening and synthesis.
- Datasheet and certificate of analysis available from the supplier.
Medchemexpress LLC CD3 epsilon Human 500ug
Recombinant human CD3 epsilon protein produced in HEK293 mammalian cells and supplied as a lyophilized preparation with a C-terminal 6xHis tag, intended for research use in studies of T-cell receptor signaling, binding assays, and related immunological applications. Lot-specific COA provides detailed formulation and buffer information.
- Produced in HEK293 mammalian expression system.
- C-terminal 6xHis tag for detection and purification.
- Lyophilized powder formulation for convenient storage and handling.
- Approximate molecular weight 18-21 kDa by SDS-PAGE.
- Stable at -20 °C for long-term storage; reconstituted stability at 4 °C for one week.
- Lot-specific COA and datasheet available for quality and formulation details.
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 95.6% | 465.97 | C23H32ClN3O5 | 5 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand provided as a hydrochloride salt for use in PROTAC construction and chemical biology research. Supplied as a research reagent, it is intended for laboratory applications and not for human use.
- Cereblon ligand suitable for E3 ligase recruitment in PROTACs and degrader design.
- Hydrochloride salt improves solubility and handling compared with the free base.
- Reported purity approximately 95.6% as supplied.
- Molecular formula C23H32ClN3O5 and molecular weight 465.97.
- Available in small research pack sizes, for example 5 mg.