Lactams
Selleck Chemical LLC Thalidomide-O-COOH
Thalidomide-O-COOH (Cereblon ligand 3 E3 ligase Ligand 3) a Thalidomide-based Cereblon (CRBN) ligand is used in the recruitment of CRBN protein Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera)
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 TFA | 2097509-49-2 | >98.3% | 514.49 | 50 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound suitable for synthesis applications.
- Used for compound synthesis
- Targeted as biochemical assay reagents
- Molecular formula: C23H29F3N4O6
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 100 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
TARGETMOL CHEMICALS INC HKI-357 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation. Purity 98.31%
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 96.0% | C24H31N3O7 | 25 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Targets E3 ligase ligand-linker conjugates, apoptosis, and autophagy
- Targets cereblon
- Appears as an off-white to light yellow solid
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | 676.67 | 1MG
VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL), which incorporates an E3 ligase ligand and an alkylC4 linker. It can be utilized for PROTAC research.
- Von-Hippel-Lindau protein ligand (VHL)
- Incorporates an E3 ligase ligand
- Incorporates an alkylC4 linker
- Suitable for PROTAC research
- Extracted from patent WO2022051326A1
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 500 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide that functions as a cereblon (CRBN) E3 ligase ligand for chemical biology and targeted protein degradation research. Identifiers: CAS 2222115-19-5; formula C13H8F2N2O4; molecular weight 294.21 g/mol. It is supplied as a research-grade solid with reported purity around 98.0%.
- Fluorinated analogue used as a cereblon E3 ligase ligand.
- Enables recruitment of CRBN for targeted protein degradation studies.
- Amenable to further derivatization via substitution at fluorine positions.
- High chemical purity (approximately 98.0%).
- Provided as a solid powder for research and analytical applications.
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 250 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used in PROTAC technology
- For research use only
- Inhibitor
Medchemexpress LLC Thalidomide-1-me-5-nh2 | 1468761-60-5 | >98.0% | 287.27 g·mol-1 | C14H13N3O4 | 50 MG
Thalidomide-1-Me-5-NH2 is an aminated thalidomide analogue used as a cereblon E3 ligase ligand and building block for PROTAC design and related chemical biology research. It is intended for derivatization at the amine for linker attachment and is supplied as a high-purity research reagent suitable for synthetic applications.
- Aminated thalidomide analogue enabling linker derivatization
- Serves as a cereblon E3 ligase ligand for PROTAC design
- High purity for research applications (>98.0%)
- Supplied in small milligram-scale quantities suitable for synthesis (50 mg)
- Molecular formula C14H13N3O4, molecular weight 287.27 g·mol-1
- CAS number 1468761-60-5 for unambiguous identification
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | 634.67 | C30H42N4O11 | 5 MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate containing a PEG3 spacer and a Boc-protected terminal amine. Supplied as a white to off-white solid at high purity, it is designed for use as a building block in PROTAC synthesis and targeted protein degradation research, enabling modular assembly of cereblon-recruiting degraders.
- Thalidomide-based cereblon ligand useful for recruiting E3 ligase.
- Peg3 linker provides a flexible spacer for conjugation to target ligands.
- Boc-protected terminal amine enables orthogonal deprotection and coupling chemistry.
- High purity suitable for synthetic and medicinal chemistry applications.
- Available in small-mass pack sizes for discovery and early-stage research.
Medchemexpress LLC Thalidomide-o-amido-c4-n3 | 2098488-36-7 | 98.4% | 428.40 | C19H20N6O6 | 25 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate containing an azide functional group. It is used as a building block in PROTAC design and as a click-chemistry reagent to attach CRBN ligands to alkyne-bearing partners, enabling targeted protein degradation applications.
- Azide functional group compatible with CuAAC and SPAAC click chemistry.
- Designed as a cereblon (CRBN) ligand-linker conjugate for PROTAC synthesis.
- High purity as supplied (LCMS ~98.4%).
- Soluble in DMSO (≥ 41 mg/mL) for in vitro formulation.
- In vivo formulation examples achieve ≥ 2.5 mg/mL in common solvents and vehicles.
- Store under inert atmosphere at 4°C; in solution store at -80°C for long-term stability.
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 500 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Utilized for the recruitment of CRBN protein
- Can be linked to a protein ligand via a linker
- Forms PROTACs
- PROTACs use the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC 4-(2-aminoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | 2341840-99-9 | MFCD32705128 | 99.4% | C15H16ClN3O5 | 10MG
Thalidomide-4-O-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in proteolysis-targeting chimera (PROTAC) research. It pairs a thalidomide-based CRBN-binding moiety with a short C2 aminoalkyl linker to enable conjugation to target ligands and recruitment of the E3 ubiquitin ligase for targeted protein degradation.
- Designed to recruit cereblon E3 ligase in PROTAC constructs.
- Short C2 aminoalkyl linker enables close proximity between ligand and E3 ligase.
- Supplied as hydrochloride salt for improved stability and handling.
- Characterized by analytical data, including H NMR and LC-MS.
- High purity suitable for research applications.
- Intended for research use only; not for human therapeutic use.
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.6% | 337.13 | C13H9BrN2O4 | 50 MG
Thalidomide-4-Br is a brominated thalidomide derivative used as a cereblon/bromodomain ligand in preclinical research on inflammation, oncology, and neurology. It is supplied as a solid, off-white to gray powder with characterized identity and stability data.
- High purity (reported ≈99.6%).
- Well characterized: CAS 2093536-12-8; formula C13H9BrN2O4; molecular weight 337.13.
- Available in multiple package sizes, including small (50 mg) and larger quantities.
- Defined storage and stability: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Suitable for cereblon-targeting studies and use as a ligand in PROTAC development.
Medchemexpress LLC Tetrazine tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 1 ML
Tz-Thalidomide is a tetrazine-tagged thalidomide derivative supplied for research use as an E3 ligase ligand and chemical biology probe. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid quantities for synthesis and assay use, and is intended for applications in targeted protein degradation and PROTAC development.
- Tetrazine functional group enables rapid inverse electron demand Diels-Alder (iEDDA) click reactions.
- Supplied as a 10 mM solution in DMSO for immediate experimental use.
- High purity (98.6%) appropriate for biological testing and chemical biology workflows.
- Molecular weight 571.58 and formula C29H29N7O6 for accurate dosing and formulation.
- Available in solid amounts for synthetic chemistry and scale-up experiments.