Lactams
Medchemexpress LLC Thalidomide-PEG5-NH2 hydrochloride | 2703775-06-6 | C23H31N3O9 | 10MG
Thalidomide-PEG5-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate intended for PROTAC development and related chemical biology applications. It links a thalidomide-based CRBN-binding moiety to a PEG5 primary amine, enabling coupling to target-binding warheads while providing documentation for synthetic and screening use.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- PEG5 amine linker enabling facile conjugation to warheads.
- Provided as a hydrochloride salt for the amine functionality.
- Available in small milligram quantities suitable for medicinal chemistry.
- Supplied with purity documentation and safety data sheet.
Medchemexpress LLC Thalidomide-5-O-C3-NH2 hydrochloride | 2694727-94-9 | MFCD34475114 | 99.1% | 367.78 g/mol | C16H18ClN3O5 | 10 MG
Thalidomide-5-O-C3-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use as a building block in targeted protein degradation research and PROTAC design. It is provided as a solid with supporting analytical data for research use.
- Acts as a cereblon-binding ligand for CRBN recruitment.
- Enables linker conjugation for PROTAC assembly.
- Supplied with high purity (99.08%).
- Provided as a solid suitable for long-term storage under recommended conditions.
- Analytical data and COA available to support research use.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | 2636798-38-2 | >95.0% | 437.92 g/mol | C21H28ClN3O5 | 10 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research applications. It is used as a recruiting moiety in PROTACs and other E3 ligase-targeting conjugates to facilitate targeted protein degradation and chemical biology studies. Supplied as a white to off-white solid in small laboratory pack sizes, it supports synthetic conjugation through an alkyl linker.
- Serves as a cereblon-recruiting ligand for targeted protein degradation
- Supplied as a hydrochloride salt for improved stability and handling
- Solid form suitable for storage and synthetic manipulation
- Provides an alkyl linker attachment point for PROTAC assembly
- Compatible with standard organic synthesis and conjugation workflows
- Intended for research use in chemical biology and drug discovery
Medchemexpress LLC (S)-thalidomide | 841-67-8 | MFCD00210219 | 99.5% | C13H10N2O4 | 10MG
(S)-Thalidomide is the S-enantiomer of thalidomide, a small-molecule ligand of the E3 ubiquitin ligase substrate receptor cereblon (CRBN). It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic activities and is used as a research reagent to study CRBN-mediated degradation pathways and molecular glue mechanisms. For research use only.
- High chemical purity suitable for analytical and biological studies.
- Known to bind cereblon and induce substrate recruitment for degradation.
- Useful in studies of immunomodulation, angiogenesis, and apoptosis.
- Available in small milligram pack sizes for screening and synthesis.
- Provided with manufacturer documentation including SDS and COA.