Lactams
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 100 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide used in bioorthogonal click-chemistry and as an E3 ligase ligand for biochemical research. It contains a reactive tetrazine group for rapid conjugation via inverse electron demand Diels-Alder reactions and has been characterized for binding to BRD4.
- Tetrazine moiety enables rapid inverse electron demand Diels-Alder (iEDDA) click reactions.
- Functions as an E3 ligase ligand for targeted protein interaction studies.
- Documented binding affinity to BRD4 in biochemical assays.
- High purity suitable for research applications.
- Available as a solid and as a 10 mM solution in DMSO for experimental flexibility.
Medchemexpress LLC Thalidomide-5-Br | 26166-92-7 | 98.4% | 337.13 g/mol | C13H9BrN2O4 | 50 MG
Thalidomide-5-Br is a brominated thalidomide analogue supplied for biochemical research. It has a reported molecular weight of 337.13 g/mol and is supplied as an off-white to gray solid with reported purity around 98%.
- Used in research of inflammation, tumor biology, and neurology.
- Supplied as a solid suitable for formulation or dissolution in solvent for experimental use.
- Reported high purity for analytical and preclinical studies.
- Stable at room temperature for extended storage; in-solution storage requires low temperatures.
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 99.6% | 353.76 | 5MG
Thalidomide-5-O-C2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed for the recruitment of CRBN protein. This compound can be linked to a protein ligand via a linker to form PROTACs, which are relevant in cancer targeted therapy and metabolism research.
- Used for the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker to form PROTACs
- Target is Cereblon
- Involved in E3 ligase ligand-linker conjugates, apoptosis, and autophagy research
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | ≥98% | 437.92 | 5 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a cereblon ligand derived from Thalidomide. It is utilized to recruit CRBN protein and can be linked to a target protein ligand via a linker to form PROTACs.
- It is a cereblon ligand.
- It is used in the recruitment of CRBN protein.
- It can be connected to a ligand for protein by a linker to form PROTACs.
- It is intended for research purposes only and not for sale to patients.
Medchemexpress LLC 1H-isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 500 MG
Thalidomide-iodo is an iodinated derivative of thalidomide used as an E3 ligase (cereblon) activator for research applications. It is intended as a building block and synthetic intermediate for further derivatization by substitution of the iodine atom.
- E3 ligase activator (cereblon ligand) for targeted protein degradation research.
- Suitable as a synthetic intermediate for iodide substitution and further derivatization.
- High purity: 98.0% (NMR).
- Molecular formula C13H9IN2O4; molecular weight 384.13.
- CAS number 2509137-01-1.
- Appearance: gray to dark gray solid.
- Storage: 4°C, protect from light; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.45% | 50 MG
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker. It can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709).
- Incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker.
- Used to design PROTAC CDK2/9 degrader-1.
- For research use only.
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.2% | C25H32N6O10 | 50 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 25 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is a click chemistry reagent containing an Azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Contains an Azide group for click chemistry
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Target: Cereblon
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 50 MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide based cereblon ligand and a linker. This product can be used for the synthesis of PROTAC BET degrader.
- E3 ligase ligand-linker conjugate
- Thalidomide based cereblon ligand
- PROTAC BET degrader synthesis
- Inhibitor