Lactams
Cayman Chemical AzIdo-ThalIdomIde 5mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC α-MSH (α-Melanocyte-Stimulating Hormone) | 581-05-5 | 99.9% | 1664.88 | 5 MG
α-MSH (α-Melanocyte-Stimulating Hormone) | 581-05-5 | 99.9% | 1664.88 | 5 MG
Medchemexpress LLC 3-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethoxy)propanoic acid | 2731007-11-5 | 99.2% | C22H26N4O7 | 10MG
Thalidomide-Piperazine-PEG1-COOH is an E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a short PEG1-piperazine linker terminated by a carboxylic acid. It is provided as a solid research reagent intended for use as a CRBN-binding module in PROTAC design and conjugation studies.
- Enables CRBN engagement via a thalidomide-derived ligand.
- Features a PEG1-piperazine linker with a terminal carboxylic acid for conjugation.
- High reported purity enables reliable analytical and synthetic work.
- Solid, white-to-yellow appearance for easy handling and storage.
- Recommended storage at -20°C under inert gas to preserve integrity.
- Available in small milligram quantities suitable for early-stage research.
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | 2376990-30-4 | 498.91 | 100 MG
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, and can be an immunomodulator for the treatment of cancer. It is for research use only and not sold to patients. PROTACs contain two different ligands connected by a linker, one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates an E3 ligase ligand and a linker
- Can be an immunomodulator for the treatment of cancer
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 500 MG
Thalidomide-O-C8-Boc is a Cereblon ligand that recruits the CRBN protein. It can be linked to target protein ligands via a linker to form PROTACs. This product is intended for research use only.
- Cereblon ligand
- Recruits CRBN protein
- Can form PROTACs when linked to a target protein ligand
- For research use only
- Purity: 95.12%
- Molecular weight: 486.56
- Formula: C26H34N2O7
- Appearance: solid, white to off-white
- Storage: -20°C, under nitrogen; in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Thalidomide-O-C8-COOH | 2225148-51-4 | 97.4% | 430.45 g/mol | C22H26N2O7 | 5 MG
Thalidomide-O-C8-COOH is a thalidomide-derived cereblon ligand with a carboxy-terminated eight-carbon linker, developed for use as an E3 ligase recruiter in targeted protein degradation. It is provided as a high-purity solid optimized for conjugation into PROTACs and other bifunctional degraders, with documented solubility and storage recommendations for research workflows.
- High purity (97.4%) suitable for research applications.
- Carboxy-terminated C8 linker for convenient coupling chemistry.
- Molecular weight 430.45 g/mol; formula C22H26N2O7.
- High solubility in DMSO for preparation of concentrated stock solutions.
- Storage and solvent stability data provided for reliable handling.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 290.25 | C14H11FN2O4 | 250 MG
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative used as an E3 ubiquitin ligase activator in research. Supplied as a solid for laboratory use, it functions as a synthetic building block for further derivatization and for studies that probe E3 ligase-mediated pathways. Consult the product datasheet for lot-specific purity and analytical data.
- Fluorinated E3 ligase activator suitable for biochemical assays
- Reactive position enables SNAr derivatization for synthesis
- Supplied as a solid in multiple laboratory scales
- Molecular formula C14H11FN2O4; molecular weight 290.25
- Powder storage: -20°C (long term) or 4°C (short term)
- Data sheet and certificate of analysis available for purity and handling
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 250 MG
Thalidomide-4,5-F is a fluorinated thalidomide analogue used as a cereblon (CRBN) ligand and E3 ligase recruiter for chemical biology and PROTAC research. It promotes ubiquitinylation of target proteins and can be derivatized at fluorine positions. Supplied as a solid powder with high purity and recommended cold storage conditions.
- Fluorinated analogue designed for cereblon engagement.
- High purity suitable for research applications.
- Available in multiple milligram-scale pack sizes.
- Stable solid form with defined cold storage conditions.
- Modifiable at fluorine positions for derivatization.
Medchemexpress LLC Thalidomide-O-amido-PEG-C2-NH2 hydrochloride | 2204226-02-6 | 98.1% | 5MG
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride | 2204226-02-6 | 98.1% | 5MG
Medchemexpress LLC Thalidomide-nh-c4-nh-boc | 2093388-52-2 | 99.6% | 444.48 g/mol | C22H28N4O6 | 5 MG
Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate developed for PROTAC research. It combines a cereblon-binding thalidomide moiety with a Boc-protected four-carbon linker to facilitate targeted protein degradation studies. For research use only.
- High purity: 99.64% by analytical HPLC.
- Appropriate for PROTAC development as a cereblon ligand-linker conjugate.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Storage: store at 4°C and protect from light; in solvent, -80°C (6 months) or -20°C (1 month).
- Available in small mg quantities suitable for medicinal chemistry applications.