Lactams
Cayman Chemical AzIdo-ThalIdomIde 10mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-4-O-C10-COOH | 2379870-45-6 | MFCD03424822 | 99.1% | 458.50 g·mol⁻¹ | C24H30N2O7 | 5 MG
Thalidomide-4-O-C10-COOH is an E3 ligase ligand-linker conjugate intended as a building block for PROTAC synthesis. It features a thalidomide-derived cereblon-recruiting motif linked via a C10 spacer to a terminal carboxylic acid, allowing standard coupling chemistry for attachment to target-binding ligands. Supplied as a high-purity solid for laboratory research use.
- High purity suitable for synthesis work.
- Carboxylic acid terminus for standard coupling reactions.
- Contains a C10 spacer to provide linker flexibility.
- Molecular formula: C24H30N2O7; molecular weight: 458.50 g·mol⁻¹.
- Supplied in small mg-scale quantities appropriate for research.
Medchemexpress LLC Thalidomide-NH-C6-NH2 (hydrochloride) | 2375194-37-7 | 99.6% | 250 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | 548.59 | 50 MG
Thalidomide-NH-PEG3-NH-Boc is a laboratory chemical intended for research use only. It is suitable for the manufacture of substances and should be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- For laboratory use
- For research purposes only
- To be handled by experienced personnel
- Requires appropriately equipped and authorized facilities
Medchemexpress LLC Thalidomide-O-PEG4-amine (hydrochloride) | 2820929-03-9 | C23H32ClN3O9 | 50 MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates thalidomide based cereblon ligand
- Uses a linker in PROTAC technology
- Targets E3 ligase ligand-linker conjugates, apoptosis, and autophagy
Selleck Chemical LLC Thalidomide-O-COOH
Thalidomide-O-COOH (Cereblon ligand 3 E3 ligase Ligand 3) a Thalidomide-based Cereblon (CRBN) ligand is used in the recruitment of CRBN protein Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera)
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 TFA | 2097509-49-2 | >98.3% | 514.49 | 50 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound suitable for synthesis applications.
- Used for compound synthesis
- Targeted as biochemical assay reagents
- Molecular formula: C23H29F3N4O6
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.26% | 388.37 | 100 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, which is the final step intermediate in the synthesis of Thalidomide-4-OH. It acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. It is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
- Acts as a Cereblon ligand to recruit CRBN proteins.
- The t-Bu protecting group can be removed under acidic conditions to participate in the synthesis of PROTAC molecules.
- Key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97.9% | 441.86 g·mol⁻1 | C19H24ClN3O7 | 5 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a PEG3 linker terminating in a primary amine. Supplied as the hydrochloride salt, it is intended as a building block for PROTAC design and bioconjugation chemistry.
- Contains a PEG3 linker with a terminal primary amine for conjugation.
- Supplied as hydrochloride salt to aid handling and stability.
- Intended for use as an E3 ligase recruiting ligand in PROTAC synthesis.
- High reported purity suitable for research applications.
- Available in small research sizes for medicinal chemistry workflows.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 95.0% | 384.19 g·mol⁻¹ | C19H21BN2O6 | 10 MG
Thalidomide-pinacolborane is a thalidomide-derived small molecule bearing a pinacol boronic ester (Bpin). It serves as an E3 ligase (cereblon) ligand useful in targeted protein degradation (PROTAC) research and as a synthetic intermediate for cross-coupling chemistries.
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 50 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate designed for research purposes. It integrates a thalidomide-based cereblon ligand and a linker, both crucial components utilized in PROTAC (Proteolysis Targeting Chimeras) technology. This product is not intended for patient use.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a thalidomide-based cereblon ligand
- Includes a linker commonly used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Appears as a white to off-white solid
- Available in various quantities with specific storage guidelines
- Supplied with a Data Sheet, Certificate of Analysis (COA), Safety Data Sheet (SDS), and Handling Instructions
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | N/A | 97.0% | 384.19 g/mol | C19H21BN2O6 | 5 MG
Thalidomide-pinacolborane is a thalidomide analogue bearing a pinacolborane (Bpin) group, used as a synthetic intermediate and as a ligand for E3 ligase in PROTAC research. Molecular formula C19H21BN2O6, molecular weight 384.19 g/mol. Manufacturer documentation lists CAS 2229725-98-6 and purity 97.0%. Recommended storage is -20°C under nitrogen; in solvent, -80°C (up to 6 months) or -20°C (up to 1 month) under nitrogen.
- Functionalized thalidomide analogue useful as a synthetic intermediate.
- Serves as a ligand for E3 ligase in PROTAC applications.
- High purity (97.0%) suitable for research use.
- Stable when stored under nitrogen at recommended temperatures.
- Available in small research sizes down to 5 mg.
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 100 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only