Lactams
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 25 MG
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker. This compound is suitable for designing PROTAC CDK2/9 Degrader-1.
- Incorporates a CRBN ligand for the E3 ubiquitin ligase and a linker
- Targets cereblon
- Has a molecular weight of 416.38
- Has a molecular formula of C19H20N4O7
- Appears as a solid with a light yellow to yellow color
- Purity of 98.45%
- Soluble in DMSO at 100 mg/mL (requires ultrasonic)
- Powder storage: -20°C for 3 years
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
Sigma Aldrich Fine Chemicals Biosciences (+)-Thalidomide >=98% (HPLC), powder | 2614-06-4 | MFCD00210220 | 10MG
(+)-Thalidomide >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 258.23 | 2614-06-4 | MFCD00210220 | 10MG
![Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261970.png-250.jpg)
Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.
- Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
- Thalidomide-based ligand with a six-carbon carboxylic acid linker.
- High purity, 99.3% (reported).
- Soluble ≥100 mg/mL in DMSO.
- Off-white to light yellow solid suitable for synthesis.
- Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
- Storage recommendations provided for powder and solutions to maintain stability.
![eMolecules 921755-46-6 | (1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | Synthonix - Stock355.260 | C14H24Cl2N2O4 | 95.000 | Cl.Cl.OC(=O)[C@H]1C[C@H]2CC[N@@]1C2.OC(=O)[C@@H]1C[C@@H]2CC[N@]1C2 | 1g | 499991381](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502168053.JPG-250.jpg)
eMolecules 921755-46-6 | (1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | Synthonix - Stock355.260 | C14H24Cl2N2O4 | 95.000 | Cl.Cl.OC(=O)[C@H]1C[C@H]2CC[N@@]1C2.OC(=O)[C@@H]1C[C@@H]2CC[N@]1C2 | 1g | 499991381
(1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | Synthonix - Stock | 921755-46-6355.260 | C14H24Cl2N2O4 | 95.000 | Cl.Cl.OC(=O)[C@H]1C[C@H]2CC[N@@]1C2.OC(=O)[C@@H]1C[C@@H]2CC[N@]1C2 | 1g | 499991381
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 50 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Uses a linker in PROTAC technology
- Targets Cereblon
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-Piperazine 5-fluoride | 2222114-22-7 | >96.5% | 360.34 | 5 G
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate. Its intended use is for research purposes, specifically in the field of PROTAC (Proteolysis Targeting Chimeras) technology. It incorporates a thalidomide-based cereblon ligand and a linker. This product is not for sale to patients.
- Appearance: Solid, light yellow to green yellow
- Solubility: Soluble in DMSO (5.83 mg/mL or 16.18 mM)
- Storage: 4°C, protect from light; in solvent: -80°C for 6 months, -20°C for 1 month (protect from light)
- Related research areas: Cancer, PROTAC, autophagy, apoptosis, E3 ligase ligand-linker conjugates
- Cereblon ligand: Incorporates a thalidomide-based cereblon ligand
- PROTAC technology: Utilizes a linker commonly used in PROTAC technology
Medchemexpress LLC Thalidomide-PEG4-COOH | 2828438-28-2 | 95.4% | 478.45 | 50 MG
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes a linker in PROTAC technology
- For research use only
- Appears as an oil
- Color is colorless to light yellow
Medchemexpress LLC Thalidomide-5-NH2-CH2-COOH | 2412056-27-8 | 95.00% | C15H13N3O6 | 50 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). It also functions as a ligand of E3 ligase and has potential for researching various diseases, as referenced in patent WO2021170109A1. This compound has a molecular weight of 331.28 and appears as a solid, ranging from light yellow to green yellow in color.
- Potent and selective inhibitor of tropomyosin receptor kinase (trk)
- Functions as a ligand of E3 ligase
- Potential for researching various diseases
- Appearance: solid, light yellow to green yellow
Cayman Chemical -ThalIdomIde 500mg
An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 UG/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 UG/kg egg weight)
Medchemexpress LLC Thalidomide-O-amido-C4-N3 | 2098488-36-7 | MFCD31560486 | 98.4% | 428.40 g/mol | C19H20N6O6 | 10 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived cereblon ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) and E3 ligase ligand research. It is provided with analytical characterization and storage guidance for research applications.
- Used as a cereblon ligand-linker conjugate for PROTAC and E3 ligase research.
- Molecular formula C19H20N6O6; molecular weight 428.40 g/mol.
- CAS number 2098488-36-7 for unambiguous identification.
- Purity 98.4% by LCMS (as supplied).
- Supplied in small research quantities (for example, 10 mg) and as stock solution preparations.
- Soluble in DMSO and compatible solvent systems for formulation.
- Store at 4°C under nitrogen; in solution, store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | >98.0% | 292.68 | C13H9ClN2O4 | 5 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as an E3 ligase (cereblon) ligand/activator for research use. It is commonly used as a synthetic building block in PROTAC design and for studies involving CRBN recruitment, where the 4-chloro group can be substituted to create derivatives.
- Functions as an E3 ligase (cereblon) ligand for biochemical studies.
- Useful for PROTAC design and cereblon recruitment assays.
- Enables further derivatization via substitution at the 4-chloro position.
- Available in laboratory pack sizes suitable for synthesis and screening.
- Analytical data and a product datasheet are available for reference.
Medchemexpress LLC Thalidomide-PEG5-COOH | 2688100-28-7 | 95.9% | 522.50 | 25 MG
Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only and not for medical, clinical diagnostic, or food use in humans or animals.
- Purity: 95.90%
- Appearance: Oil
- Color: Light yellow to brown
- Solubility: Soluble in DMSO at 50 mg/mL (95.69 mM)
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 10 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Cereblon-based ligand derived from Thalidomide. It functions by recruiting the CRBN protein. This compound can be linked to an IRAK4 protein ligand using a linker to create PROTAC IRAK4 degrader-1 (HY-129966).
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to other ligands via a linker to form PROTACs
Medchemexpress LLC Thalidomide-4-O-C9-NH2 hydrochloride | >98.0% | 451.94 g/mol | C22H30ClN3O5 | 10 MG
Thalidomide-4-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for use in targeted protein degradation and PROTAC development. Supplied as the hydrochloride salt for conjugation chemistry, the compound is offered for research use and is commonly provided in small milligram quantities for medicinal chemistry and chemical biology applications.
- Acts as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Designed for use in PROTAC and targeted protein degradation research.
- Provided as a hydrochloride salt suitable for conjugation chemistry.
- Reported purity ≥98% according to vendor listings.
- Molecular weight ~451.94 g/mol; formula C22H30ClN3O5.
- Store sealed at -20°C to maintain stability.