Lactams
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 g/mol | C27H40ClN3O5 | 10 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied for research use in targeted protein degradation and PROTAC development. It is provided as a small-quantity, high-purity solid suitable for conjugation through linkers to build bifunctional degraders and other CRBN-recruiting constructs.
- High purity of 97.7%.
- Molecular weight 522.08 g/mol and chemical formula C27H40ClN3O5.
- White to off-white solid appearance.
- Storage recommendations: -20 °C; in solvent: -80 °C (6 months) or -20 °C (1 month), protect from light, store under nitrogen.
- Suitable for use as a CRBN-recruiting ligand in PROTAC synthesis.
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 500 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Uses a 2-unit PEG linker
- Utilized in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 50 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, serving as the final intermediate in the synthesis of Thalidomide-4-OH. It functions as a Cereblon ligand, recruiting CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to facilitate the synthesis of PROTAC molecules. This compound is a crucial intermediate for synthesizing CRBN-based designed PROTAC molecules.
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group can be removed under acidic conditions
- Key intermediate for synthesizing CRBN-based designed PROTAC molecules
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 99.6% | 353.76 | 5MG
Thalidomide-5-O-C2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed for the recruitment of CRBN protein. This compound can be linked to a protein ligand via a linker to form PROTACs, which are relevant in cancer targeted therapy and metabolism research.
- Used for the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker to form PROTACs
- Target is Cereblon
- Involved in E3 ligase ligand-linker conjugates, apoptosis, and autophagy research
Medchemexpress LLC DDL-357 | 3077900-08-1 | 98.3% | 440.95 | 100 MG
DDL-357 is a potent secreted clusterin enhancer that reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model. It is for research use only and not sold to patients.
- Potent secreted clusterin enhancer
- Reduces phospho-tau in brain
- Improves memory in the murine 3xTg-AD model
- For research use only