Lactams
Selleck Chemical LLC Tazobactam Sodium-E0167-5MG
Tazobactam (Tazobactam acid Tazobactamum) Sodium is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 25 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and 2-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- 2-unit PEG linker
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 (TFA) | 1950635-14-9 | 99.8% | 544.48 | 50 MG
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand and a linker. This compound is suitable for use in the synthesis of PROTACs, which function by exploiting the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand and a linker
- Used in the synthesis of PROTACs
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-4-O-C10-COOH | 2379870-45-6 | MFCD03424822 | 99.1% | 458.50 g·mol⁻¹ | C24H30N2O7 | 5 MG
Thalidomide-4-O-C10-COOH is an E3 ligase ligand-linker conjugate intended as a building block for PROTAC synthesis. It features a thalidomide-derived cereblon-recruiting motif linked via a C10 spacer to a terminal carboxylic acid, allowing standard coupling chemistry for attachment to target-binding ligands. Supplied as a high-purity solid for laboratory research use.
- High purity suitable for synthesis work.
- Carboxylic acid terminus for standard coupling reactions.
- Contains a C10 spacer to provide linker flexibility.
- Molecular formula: C24H30N2O7; molecular weight: 458.50 g·mol⁻¹.
- Supplied in small mg-scale quantities appropriate for research.
Medchemexpress LLC Thalidomide-4-O-C2-NH2 hydrochloride | 2341840-99-9 | 99.4% | 353.76 | 25 MG
Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide based cereblon ligand and a linker used in PROTAC technology, which exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand
- Utilizes PROTAC technology
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
- Targets Cereblon
- Involved in Apoptosis and Autophagy pathways
Selleck Chemical LLC Thalidomide-O-COOH
Thalidomide-O-COOH (Cereblon ligand 3 E3 ligase Ligand 3) a Thalidomide-based Cereblon (CRBN) ligand is used in the recruitment of CRBN protein Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera)
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 TFA | 2097509-49-2 | >98.3% | 514.49 | 50 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound suitable for synthesis applications.
- Used for compound synthesis
- Targeted as biochemical assay reagents
- Molecular formula: C23H29F3N4O6
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 TFA | 1950635-14-9 | 99.8% | 544.48 | 500 MG
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker. It can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
TARGETMOL CHEMICALS INC HKI-357 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation. Purity 98.31%