Lactams
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 (TFA) | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 1 G
Thalidomide-O-amido-C4-NH2 (TFA) is a thalidomide-derived cereblon ligand supplied as the trifluoroacetate salt and intended as a building block for E3 ligase ligand-linker conjugates and PROTAC research. The compound is provided as a solid research reagent with characterized purity, formula, and solubility data for in vitro and in vivo formulation.
- Intended for research use only.
- High purity 99.92%.
- Molecular weight 516.42 g/mol.
- Molecular formula C21H23F3N4O8.
- Soluble in DMSO (~42.86 mg/mL); multiple in vivo formulation protocols reported.
- Store dry at 4°C; in solvent store at -80°C for up to 6 months.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 g/mol | C21H28ClN3O8 | 5 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide moiety with a four-unit PEG linker. It is intended as a research reagent for PROTAC design and targeted protein degradation studies and is supplied as a light yellow to yellow oil with reported high purity.
- Designed as an E3 ligase ligand-linker conjugate for PROTAC synthesis.
- Contains a cereblon-binding thalidomide moiety with a PEG4 linker for linker flexibility.
- High reported purity suitable for research applications (95.2%).
- Soluble in DMSO at 100 mg/mL; ultrasonic agitation recommended.
- Light yellow to yellow oil; easy to handle in synthetic workflows.
- Store sealed away from moisture; recommended storage at -20°C (in solvent: -80°C for long term).
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 50 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. This product is intended for research use only and for experienced personnel in appropriately equipped facilities.
- Incorporates Thalidomide-based cereblon ligand
- Features a 2-unit PEG linker
- Used in PROTAC technology
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Identified as laboratory chemicals for substance manufacture
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride | 2376990-30-4 | 498.91 | 50 MG
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, and can be an immunomodulator for the treatment of cancer. PROTACs, which contain two different ligands connected by a linker (one for an E3 ubiquitin ligase and the other for the target protein), exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates an E3 ligase ligand and a linker.
- Can be an immunomodulator for the treatment of cancer.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- For research use only.
Selleck Chemical LLC Brucine sulfate heptahydrate
Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 500 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Uses a 2-unit PEG linker
- Utilized in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-5-nh2-c8-nh2 tfa | 2097509-49-2 | 98.3% | 514.49 | 100 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound that can be used for compound synthesis. It is for research purposes only and not for sale to patients.
- Appearance: Solid
- Color: Light yellow to green yellow
- Molecular Formula: C23H29F3N4O6
Apexbio Technology LLC Thalidomide 50-35-1 200mg
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Medchemexpress LLC Thalidomide (Standard) | 50-35-1 | 100.0% | 258.23 | 50 MG
Thalidomide (Standard) | 50-35-1 | 100.0% | 258.23 | 50 MG
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | >95.0% | C30H44Cl2FN5O5S | 10MG
VH 101 phenol-alkylC4-amine dihydrochloride is a von Hippel-Lindau (VHL) protein ligand developed as a building block for PROTAC synthesis and E3 ligase conjugation. Supplied as the dihydrochloride salt, it is intended for research use in targeted protein degradation and conjugation workflows.
- VHL ligand suitable for PROTAC synthesis and E3 ligase recruitment.
- Dihydrochloride salt for improved handling and conjugation chemistry.
- Molecular formula C30H44Cl2FN5O5S; molecular weight 676.67 g/mol.
- Purity reported as ≥95.0% by HPLC in supplier documentation.
- Recommended storage: keep dry at room temperature; in solvent store at -80°C (2 years) or -20°C (1 year).
- Intended for research use in targeted protein degradation and conjugation workflows.
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | C19H24ClN3O5 | 10MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in PROTAC research, notably as a component of the degrader dTAG-13 that directs FKBP12F36V and BET proteins for degradation. It is intended for laboratory research into E3 ligase recruitment, targeted protein degradation, apoptosis, and autophagy.
- High purity suitable for research (98.5%).
- Soluble in DMSO at 83.33 mg/mL (203.31 mM); ultrasonic assistance may be needed.
- Engages cereblon for E3 ligase-mediated protein degradation.
- Useful for PROTAC assembly and linker conjugation workflows.
- Available in small research quantities to support assay development.
- Recommended storage: 4°C sealed, away from moisture and light; in solvent, store at -80°C for long term.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 50 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, serving as the final intermediate in the synthesis of Thalidomide-4-OH. It functions as a Cereblon ligand, recruiting CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to facilitate the synthesis of PROTAC molecules. This compound is a crucial intermediate for synthesizing CRBN-based designed PROTAC molecules.
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group can be removed under acidic conditions
- Key intermediate for synthesizing CRBN-based designed PROTAC molecules
![Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386961-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG
DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.
- Reduces phospho-tau in brain.
- Improves memory in the murine 3xTg-AD model.