Lactams
Medchemexpress LLC CD23/Fc epsilon RII 10ug
CD23/Fc epsilon RII Protein a low-affinity receptor for IgE and CR2/CD21 regulates IgE production and B cell differentiation On B cells it initiates IgE-dependent antigen uptake and presentation to T cells On macrophages IgE binding induces intracellular killing of parasites through the L-Arginine-nitric oxide pathway CD23/Fc epsilon RII homotrimer interacts with IGHE to regulate IgE homeostasis and with CR2/CD21 for binding CD23/Fc epsilon RII Protein Mouse (HEK293 His) is the recombinant mouse-derived CD23/Fc epsilon RII protein expressed by HEK293 with N-His labeled tag
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | 99.0% | C20H23N3O8 | 10MG
Thalidomide-NH-PEG2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate designed as a building block for PROTAC and targeted protein degradation research. It couples a CRBN-recruiting thalidomide moiety to a short PEG2 spacer terminated with a carboxylic acid, facilitating conjugation to warheads or scaffolds for degrader design.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- PEG2 linker terminated with carboxylic acid for conjugation.
- Suitable as a building block for PROTAC synthesis and linker optimization.
- High purity (99.0%) supporting reproducible conjugation chemistry.
- Molecular formula C20H23N3O8; molecular weight 433.41 g/mol.
- Supplied in small milligram pack sizes for research use.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | C21H28ClN3O8 | 10MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived cereblon ligand conjugated to a PEG4 linker and supplied as the hydrochloride salt. It serves as an E3 ligase ligand-linker building block for PROTAC design and related chemical biology research.
- Incorporates thalidomide-based cereblon ligand for E3 ligase recruitment.
- PEG4 linker provides a flexible spacer for bifunctional molecule design.
- Hydrochloride salt form improves handling and solubility properties.
- Intended for use in proteolysis-targeting chimera (PROTAC) synthesis.
- Molecular weight 485.92 g/mol; chemical formula C21H28ClN3O8.
- Manufacturer-reported purity 95.2% suitable for research applications.
Medchemexpress LLC Thalidomide-NH-PEG1-NH2 hydrochloride | 2154342-56-8 | 99.2% | C17H21ClN4O5 | 10MG
Thalidomide-NH-PEG1-NH2 hydrochloride is a thalidomide-derived cereblon E3 ligase ligand-linker conjugate supplied as the hydrochloride salt and intended as a building block for PROTAC design and small-molecule degradation strategies. It couples a cereblon-recruiting moiety with a short PEG1 diamine linker to facilitate conjugation to target-binding ligands and streamline synthesis workflows.
- Provides thalidomide-based cereblon recruiting moiety.
- Includes a short PEG1 diamine linker for flexibility in conjugation.
- Supplied as hydrochloride salt for improved stability and handling.
- High purity suitable for synthetic applications (99.2%).
- Available in small milligram quantities for early-stage research.
Medchemexpress LLC 14-3-3 epsilon protein, mouse (His) | ≥98.0% | 50 UG
Recombinant mouse 14-3-3 epsilon His-tag protein supplied as a lyophilized powder for research use. The protein is produced in Escherichia coli, carries an N-terminal 6xHis affinity tag, and has an approximate molecular weight of 31 kDa. Supplied with high purity and low endotoxin for biochemical assays and binding studies.
- Recombinant protein expressed in Escherichia coli.
- N-terminal 6xHis tag for affinity purification and detection.
- Lyophilized powder formulation for extended shelf life.
- Approximate molecular weight 31 kDa.
- Purity ≥98.0% by reducing SDS-PAGE.
- Endotoxin <1 EU/μg (LAL), suitable for in vitro assays.
- Formulated in Tris-HCl, NaCl; reconstitute at ≥100 μg/mL.
- Store lyophilized at -20°C; freeze aliquots at -80°C for long term.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC Tz-thalidomide (tetrazine tagged thalidomide) | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 50 MG
Tz-thalidomide is a tetrazine-tagged derivative of thalidomide designed for research applications in click chemistry and targeted protein degradation. It is supplied as a pink to red solid with high purity and is formulated for solubility in DMSO for in vitro use.
- Tetrazine-functionalized thalidomide scaffold for iEDDA click reactions.
- High purity (98.6%) suitable for biochemical assays.
- Solid, pink to red form that is stable under recommended storage conditions.
- Good solubility in DMSO (50 mg/mL) for stock preparation.
- Available in small research quantities compatible with probe synthesis.
- Applicable as an E3 ligase ligand for PROTAC and molecular-glue studies.