Lactams
Medchemexpress LLC Thalidomide-5-br | 26166-92-7 | MFCD30188073 | 98.4% | 337.13 | C13H9BrN2O4 | 5 MG
Thalidomide-5-Br is a brominated derivative of thalidomide provided for research use. It is described as a compound with a bromodomain and is used in preclinical studies of inflammation, tumor biology, and neurology.
- Used in research related to inflammation, tumor biology, and neurology.
- High purity suitable for biochemical assays and medicinal chemistry.
- Available in small milligram quantities for discovery studies.
- Stable at room temperature for extended storage under recommended conditions.
- Contains a bromodomain-containing structure for target engagement studies.
![eMolecules [cis-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methanol | | | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502160039.JPG-250.jpg)
eMolecules [cis-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methanol | | | 1g
Pharmablock | [cis-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methanol | 1g | 551294267 | PBU4956 | | | | 285.503 | C15H31NO2Si
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eMolecules Building Block Tool
Cayman Chemical AzIdo-ThalIdomIde 25mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 25 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and 2-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- 2-unit PEG linker
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Apexbio Technology LLC Laurocapram 59227-89-3 1g
Laurocapram is an amphiphilic compound primarily applied as a percutaneous absorption enhancer Laurocapram exerts its biological activity by temporarily altering the lipid architecture within the stratum corneum thereby lowering barrier resistance and increasing skin and mucosal permeability to both hydrophilic and lipophilic substances Based on these pharmacological properties Laurocapram holds research potential in the investigation of transdermal drug delivery mechanisms evaluation of pharmacokinetic profiles and the development of topical therapeutic agents and delivery formulations
Apexbio Technology LLC Thalidomide 50-35-1 10mM (in 1mL DMSO)
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Medchemexpress LLC (S)-Thalidomide | 841-67-8 | 99.5% | 258.23 | 100 MG
(S)-Thalidomide is the S-enantiomer of Thalidomide. It possesses immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN).
- Immunomodulatory effects
- Anti-inflammatory effects
- Antiangiogenic effects
- Pro-apoptotic effects
- Induces teratogenic effects by binding to cereblon (CRBN)
- For research use only
Medchemexpress LLC Thalidomide-5-O-C13-NH2 (hydrochloride) | 99.9% | 508.05 | 5 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a cereblon ligand based on Thalidomide. It is utilized in the recruitment of CRBN protein and can be connected to a protein ligand by a linker to form PROTACs.
- Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker
- Forms PROTACs
Medchemexpress LLC Thalidomide-4-O-C14-NH2 hydrochloride | 99.85% | 522.08 | 25 MG
Thalidomide-4-O-C14-NH2 hydrochloride is a Thalidomide (HY-10984)-based cereblon ligand that is used in the recruitment of CRBN protein. It can be linked to a protein ligand to create PROTACs. It is for research use only.
- Functions as a ligand for E3 Ligase.
- Involved in the recruitment of CRBN protein.
- Can be connected via a linker to a protein ligand to form PROTACs.
- Intended for research use only.
Medchemexpress LLC Aztreonam | 78110-38-0 | 99.6% | 200 MG
Aztreonam (SQ-26,776) is a synthetic monocyclic beta-lactam antibiotic that exhibits a very high affinity for penicillin-binding protein 3 (PBP-3). It functions by inhibiting mucopeptide synthesis within the bacterial cell wall, thereby preventing peptidoglycan crosslinking. While resistant to some beta-lactamases, it is inactivated by extended-spectrum beta-lactamases. Aztreonam demonstrates no useful activity against gram-positive or anaerobic microorganisms.
- Inhibits mucopeptide synthesis in bacterial cell walls
- Blocks peptidoglycan crosslinking
- High affinity for penicillin-binding protein 3 (PBP-3)
- Resistant to certain beta-lactamases
- Bactericidal properties
Medchemexpress LLC Aztreonam (Standard) | 78110-38-0 | 99.6% | 100 MG
Aztreonam (Standard) is an analytical reference standard. It is a synthetic monocyclic beta-lactam antibiotic exhibiting high affinity for penicillin-binding protein 3 (PBP-3), making it suitable for various research and analytical applications.
- Analytical standard grade
- Reference standard for assays
- Suitable for qualitative research
- Suitable for quantitative research
- Suitable for methodological research
- Commonly used in HPLC
- Commonly used in GC
- Commonly used in MS
Medchemexpress LLC Fc epsilon RIA/FCER1 10ug
Recombinant human Fc epsilon RIA (FCER1A) is the extracellular alpha chain of the high-affinity IgE receptor supplied as a His-SUMO-tagged recombinant protein. The lyophilized protein is intended for use in binding studies, ELISA, and other immunological or biochemical assays requiring the human FCER1A ectodomain.
- His-SUMO tagged protein for affinity purification and detection.
- Expressed in E. coli and supplied lyophilized for enhanced stability.
- Purity >95% as determined by reducing SDS-PAGE.
- Formulated with trehalose and EDTA for increased storage stability.
- Suitable for ELISA and binding assays; functional activity characterized.
- Recommended reconstitution at or above 100 μg/mL for optimal performance.
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g/mol | C13H10N2O5 | 5 G
Thalidomide-4-OH is a 4-hydroxylated thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein degradation research. It is commonly used as a building block in PROTAC design and medicinal chemistry studies and is supplied as a solid for laboratory research use only.
- Acts as a cereblon (CRBN) ligand suitable for PROTAC synthesis.
- 4-hydroxyl substitution enables linker attachment for conjugation.
- High purity supports reproducible conjugation and biological assays.
- Solid form allows convenient storage and handling.
- Useful for ligand optimization and E3 ligase recruitment studies.