Lactones
Medchemexpress LLC Butyrolactone 3 | 778649-18-6 | 99.6% | 25 MG
Butyrolactone 3 (MB-3) is a specific small-molecule inhibitor of the histone acetyltransferase Gcn5, demonstrating an IC50 of 100 μM. It shows high affinity for the Gcn5 enzyme, similar to its natural substrate histone H3, while exhibiting weak inhibitory activity on CBP (IC50=0.5 mM). This compound is valuable for research in cancer, metabolic, autoimmune, and neurological diseases.
- Specific small-molecule inhibitor of histone acetyltransferase Gcn5
- High affinity for the Gcn5 enzyme
- Weak inhibitory activity on CBP
- Useful in studies related to cancer, metabolic, autoimmune, and neurological diseases
- Reduces Gcn5 acetylation
- Induces E2A-PBX1 degradation
- Decreases protein levels of E2A-PBX1, E2A, Wnt16, and GCN5 in RCH-ACV cells
AdipoGen Butyrolactone 3
Chemical. CAS 778649-18-6. Formula C9H12O4. MW 184.2. Synthetic Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound.
AdipoGen Butyrolactone II
Chemical. CAS 87414-44-6. Formula C19H16O7. MW 356.3. Isolated from Aspergillus sp. Antibiotic. Weak cytotoxic towards bacterial and cancer cell lines. 5-Lipoxygenase 5-LOX inhibitor. Shows DPPH 2,2-diphenyl-1-picrylhydrazyl radical-scavening activity.
Medchemexpress LLC β-propiolactone | 57-57-8 | MFCD00005169 | 99.4% | 72.06 g·mol⁻¹ | C3H4O2 | 100 MG
Propiolactone (β-propiolactone) is a reactive four-membered lactone used as a chemical viral inactivator and research reagent. It is supplied for analytical and inactivation applications and is intended for research use only, not for human or clinical use.
- High purity (99.36%).
- Molecular weight 72.06 g·mol⁻¹.
- Molecular formula C3H4O2.
- Synonyms include β-propiolactone and 2-oxetanone.
- Available as a liquid 100 MG and as a 10 mM solution (1 mL) in DMSO.
- Storage: pure -20°C up to 3 years; in solvent -80°C for 6 months or -20°C for 1 month.
- Intended for laboratory research; controlled-substance restrictions may apply in some territories.
Medchemexpress LLC Propiolactone | 57-57-8 | 99.36% | 72.06 | 25 MG
Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. It has been used to inactivate SARS-CoV and as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL).
- Causes infectious inactivation of viruses.
- Used as a bacteriostatic agent to formulate BPL-inactivated influenza virus vaccine.
- Can be used for vaccine purification.
- Inactivated virus loses infectivity in Vero cells.
Medchemexpress LLC Butyrolactone I (olomoucin) | 87414-49-1 | MFCD03453074 | 99.8% | 424.44 | C24H24O7 | 5 MG
Butyrolactone I (olomoucin) is an orally active, ATP-competitive cyclin-dependent kinase 1 (CDK1) inhibitor used in preclinical research to study cell-cycle regulation, apoptosis, and inflammatory signaling. It has reported activity against NF-κB and PERK/CHOP pathways and is commonly used in cancer and metabolic disease research.
- ATP-competitive CDK1 inhibitor
- Reported modulation of NF-κB, PERK/CHOP, and apoptosis pathways
- High purity suitable for research applications
- Molecular formula C24H24O7; molecular weight 424.44
- Soluble in DMSO; ultrasonic assistance recommended
- Store protected from light; follow supplier solvent storage guidance
AdipoGen Butyrolactone I
Chemical. CAS 87414-49-1. Formula C24H24O7. MW 424.5. Isolated from Aspergillus terreus. Cell permeable, potent and selective cyclin-dependent kinase CDK-1 CDC2, -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.
AdipoGen Butyrolactone I
Chemical. CAS 87414-49-1. Formula C24H24O7. MW 424.5. Isolated from Aspergillus terreus. Cell permeable, potent and selective cyclin-dependent kinase CDK-1 CDC2, -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.
Medchemexpress LLC CWHM-1008 | 2362539-97-5 | 99.1% | 405.46 | 25 MG
CWHM-1008 is a potent and orally active antimalarial agent. It exhibits EC50 values of 46 nM against agent-sensitive Plasmodium falciparum 3D7 and 21 nM against drug-resistant Dd2 strains.
- Potent antimalarial agent
- Orally active
- Effective against both agent-sensitive and drug-resistant strains of Plasmodium falciparum