Oxazinanes
Medchemexpress LLC 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid | 956317-36-5 | MFCD18382679 | C10H9N3O2 | 100 G
5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid is a chemical compound primarily used as an intermediate in organic synthesis and medicinal chemistry, particularly in the synthesis of Suvorexant. It is intended for laboratory research purposes.
- Used as an intermediate in organic synthesis.
- Utilized in medicinal chemistry.
- Key component in the synthesis of Suvorexant.
- Stable under recommended storage conditions.
- Available as a solid.
- Melting point: 174-176 °C.
- Boiling point: 413 °C.
Medchemexpress LLC (3R,5R,6S)-Atogepant | 99.55% | 603.52 | 50 MG
(3R,5R,6S)-Atogepant, also known as (3R,5R,6S)-MK-8031, is an enantiomer of Atogepant. This compound acts as a calcitonin gene-related peptide receptor (CGRP) antagonist and is utilized in researching migraine.
- Enantiomer of Atogepant
- Calcitonin gene-related peptide receptor (CGRP) antagonist
- Used for researching migraine
- High purity of 99.55%
- Molecular weight: 603.52
- Store powder at -20°C for up to 3 years
- Store in solvent at -80°C for up to 6 months or -20°C for 1 month
- Soluble in DMSO (50 mg/mL)
Medchemexpress LLC Bay 61-3606 dihydrochloride | 648903-57-5 | 99.45% | 463.32 | 50 MG
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible, and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and induces a large decrease of Syk phosphorylation in K-rn cell lysates. Additionally, Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells. It is for research use only and not intended for patient use.
- Significantly reduces the cell viability of SYK-positive SH-SY5Y and SYK-negative SK-N-BE cells in a dose-dependent manner.
- Inhibits SYK activity by reducing ERK1/2 and Akt phosphorylation in neuroblastoma cell SH-SY5Y.
- Induces a large decrease of Syk phosphorylation in K-rn cell lysates.
- Leads to more efficacious reductions than TNF-related apoptosis-inducing ligand (TRAIL) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice.
Medchemexpress LLC Iadademstat dihydrochloride | 1431303-72-8 | 99.98% | 303.27 | 10 MG
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It inactivates KDM1A by irreversible binding to the flavin adenine nucleotide (FAD) cofactor. This compound exhibits high selectivity for KDM1A over MAO enzymes and KDM1B, with subnanomolar cellular activity in differentiation and colony formation assays on mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines.
- Selective irreversible KDM1A inhibitor
- Inactivates KDM1A by binding to FAD cofactor
- High selectivity for KDM1A over MAO enzymes and KDM1B
- Shows subnanomolar cellular activity in MLL-translocated AML cell lines
- Induces Cd11b differentiation marker in MLL-AF9 cells
- Reduces AML tumor growth in mice and rat xenografts
- Increases survival time in a disseminated model of T-ALL
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 50 MG
Tebanicline dihydrochloride is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.
- nAChR modulator
- Potent and orally effective analgesic activity
- Inhibits binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM
- Potent antinociceptive agent with full efficacy in models of acute and persistent pain
- Produces significant antinociceptive effects in mice against acute noxious thermal stimulation
- Orally active
- Has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | 99.2% | 530.92 | 10 MG
Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3. It shows high selectivity for Akt1 over closely related kinases like PKA and p70S6K. In vivo, it is effective in xenograft models where Akt is activated due to genetic alterations, achieving tumor growth delay, stasis, or regression.
- Highly selective and ATP-competitive pan-Akt inhibitor
- Has IC50 values of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3
- Shows over 600-fold selectivity for Akt1 against PKA, and 100-fold against p70S6K
- Effective in xenograft models where Akt is activated
- Achieves tumor growth delay, stasis, or regression in vivo
- Well tolerated in immunocompromised mice at therapeutic doses
- Enhances tumor growth inhibition in combination therapies
Medchemexpress LLC Inolitazone dihydrochloride | 223132-38-5 | 98.5% | 575.51 | 100 MG
Inolitazone dihydrochloride is a novel high-affinity PPARγ agonist, demonstrating potent anti-proliferative activities both in vitro and in vivo, with an IC50 of 0.8 nM for growth inhibition. Its biological activity is dependent on PPARγ.
- Upregulates the cell cycle kinase inhibitor p21WAF1/CIP1
- Activates PPARγ:RXRα-dependent transcription at 10 nM
- Specifically activates PPARγ, unlike PPARα or PPARδ
- Exhibits a low EC50 of 1 nM for activating PPARγ in DRO cells
- Potently inhibits growth with an IC50 of 0.8 nM
- Shows additive antiproliferative activity when combined with paclitaxel
- Inhibits tumor growth in a dose-responsive manner in vivo, including established DRO and ARO tumors
Medchemexpress LLC 6,7-Dihydro-4-benzo[b]thiophenone | 13414-95-4 | 97.0% | C8H8OS | 5 G
6,7-Dihydro-4-benzo[b]thiophenone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
- Intended for research use only
- Not for sale to patients
Medchemexpress LLC Quizartinib dihydrochloride | 1132827-21-4 | 99.8% | C29H34Cl2N6O4S | 100 MG
Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib. This compound is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor, characterized by a Kd of 1.6 nM. It is intended for research use only.
- Highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor
- Effectively inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Can be utilized in PROTAC technology to create FLT3 degraders
- Capable of inducing apoptosis
- Provides high purity for reliable research results
- Presents as a white to off-white solid
Medchemexpress LLC (6S,12aR)-tadalafil (tadalafil EP impurity C; (6S,12aR)-IC-351) | 171596-28-4 | 99.5% | C22H19N3O4 | 1 MG
(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity. It is for research use only and not sold to patients.
- Highly potent PDE5 inhibitor
- IC50 value of 5 nM
- Has blood pressure lowering activity
- For research use only
- Not sold to patients
eMolecules 885693-20-9 | 1-Boc-5,6-dihydro-2H-pyridine-3-boronic acid pinacol ester | Combi-Blocks, Inc. | MFCD10697911 | 309.210 | C16H28BNO4 | 97.000 | CC(C)(C)OC(=O)N1CCC=C(C1)B1OC(C)(C)C(C)(C)O1 | 500g | 866383557
1-Boc-5,6-dihydro-2H-pyridine-3-boronic acid pinacol ester | Combi-Blocks, Inc. | 885693-20-9 | MFCD10697911 | 309.210 | C16H28BNO4 | 97.000 | CC(C)(C)OC(=O)N1CCC=C(C1)B1OC(C)(C)C(C)(C)O1 | 500g | 866383557
eMolecules 885693-20-9 | 1-Boc-5,6-dihydro-2H-pyridine-3-boronic acid pinacol ester | Combi-Blocks | MFCD10697911 | 309.210 | C16H28BNO4 | 97.000 | CC(C)(C)OC(=O)N1CCC=C(C1)B1OC(C)(C)C(C)(C)O1 | 100g | 374520832
1-Boc-5,6-dihydro-2H-pyridine-3-boronic acid pinacol ester | Combi-Blocks | 885693-20-9 | MFCD10697911 | 309.210 | C16H28BNO4 | 97.000 | CC(C)(C)OC(=O)N1CCC=C(C1)B1OC(C)(C)C(C)(C)O1 | 100g | 374520832
Medchemexpress LLC Quisinostat (dihydrochloride) | 875320-31-3 | C21H28Cl2N6O2 | 25 MG
Quisinostat (dihydrochloride) | 875320-31-3 | C21H28Cl2N6O2 | 25 MG