Oxazinanes
Medchemexpress LLC Pramipexole dihydrochloride | 104632-25-9 | 99.7% | 284.25 | 1 ML
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist. It can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective dopamine D2-type receptor agonist
- BBB penetrant
- Useful for research into Parkinson's disease (PD) and restless legs syndrome (RLS)
- Cytoprotective properties
- Reduces infarction volume
- Improves neurological recovery
- Prevents ischemic cell death
TARGETMOL CHEMICALS INC Etelcalcetide hydrochloride
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that serves as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively reducing parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism undergoing hemodialysis. Purity 100%
Medchemexpress LLC (6S,12aR)-Tadalafil (Tadalafil EP Impurity C) | 171596-28-4 | 99.5% | C22H19N3O4 | 50 MG
(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity. It is intended for research use only and is not sold to patients.
- Highly potent PDE5 inhibitor with an IC50 value of 5 nM.
- Has blood pressure lowering activity.
- Suitable for research applications only.
Selleck Chemical LLC Gilteritinib hemifumarate S4487-5mg
Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0 29 nM/0 73 nM respectively
Cayman Chemical Fingolimod hydrochloride
An immune modulator and a prodrug form of FTY720 phosphate; decreases the number of circulating lymphocytes in mice at 1 mg/kg; increases skin allograft survival in rats from 0.3-3 mg/kg; prevents disease development in a rat model of EAE; inhibits S1P lyase from 0.3-30 µM
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 100 MG
Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor. It is provided as a light yellow to yellow solid and is intended for research use only.
- Highly selective and ATP-competitive pan-Akt inhibitor.
- Inhibits Akt1, Akt2, and Akt3 with IC50s of 5, 18, and 8 nM, respectively.
- Demonstrates high selectivity against PKA and p70S6K.
- Efficacious in cell lines and xenograft models with Akt activation.
- Can achieve tumor growth delay, stasis, or regression.
- Enhances tumor growth inhibition in combination therapies.
Cayman Chemical Y27632 hydrochloride
A potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM); also inhibits PRK2 with an IC50 value of 600 nM
Cayman Chemical PIK75 hydrochloride
A selective inhibitor of p110α with an IC50 value of 5.8 nM; inhibits p110γ and p110β with IC50 values of 0.076 µM and 1.3 µM, respectively
Medchemexpress LLC Bx471 hydrochloride | 288262-96-4 | 99.9% | 1 ML
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective, non-peptide CCR1 antagonist (Ki = 1 nM) that shows approximately 250-fold selectivity over CCR2, CCR5, and CXCR4. It is supplied for research as a ready-to-use 10 mM solution in DMSO (1 mL) or as solid quantities for reconstitution, and is commonly used in studies of CCR1 pharmacology and inflammation.
- Potent CCR1 antagonist with Ki = 1 nM.
- Approximately 250-fold selectivity versus CCR2, CCR5, and CXCR4.
- Supplied as a 10 mM solution in DMSO (1 mL) or as solids for reconstitution.
- High purity suitable for research applications.
Medchemexpress LLC Dihydro dutasteride | 164656-22-8 | MFCD24386648 | 99.7% | 530.55 g/mol | C27H32F6N2O2 | 5 MG
Dihydro dutasteride is the active metabolite of dutasteride and acts as a potent inhibitor of 5α-reductase isozymes. Supplied as a high-purity research reference standard, it is intended for use in biochemical studies, metabolite profiling, assay development, and mechanism-of-action experiments.
- High purity suitable for analytical and reference use.
- Molecular weight 530.55 g/mol.
- Chemical formula C27H32F6N2O2.
- Available in small pack sizes for laboratory assays.
- Used as a reference standard in metabolism and enzyme inhibition studies.
Selleck Chemical LLC Benactyzine hydrochloride S3701-25mg
Benactyzine hydrochloride is a centrally acting muscarinic antagonist It is used as an antidepressant in the treatment of depression and associated anxiety
TARGETMOL CHEMICALS INC ZT 52656A hydrochloride 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. ZT 52656A is a selective agonist of kappa opioid, and used for the prevention or alleviation of pain in the eye. Purity 99.7%
Apexbio Technology LLC Pitolisant hydrochloride 903576-44-3 10mM (in 1mL DMSO)
Pitolisant hydrochloride (CAS 903576-44-3) also known as BF2 649 or Ciproxidine is a potent and selective non-imidazole inverse agonist of the histamine H3 receptor exhibiting a Ki of 0 16 nM for the human recombinant receptor By targeting the H3 autoreceptor pitolisant modulates histaminergic neurotransmission and regulates the release of other neurotransmitters In vitro it demonstrates higher intrinsic activity than ciproxifan and an EC50 of 1 5 nM Pitolisant is orally bioavailable and increases brain tele-methylhistamine levels in rodents in a dose-dependent manner reflecting activation of histaminergic neurons It is widely applied in studies related to cognition epilepsy and models of neuropsychiatric disorders