Oxazinanes
TARGETMOL CHEMICALS INC Gilteritinib hemifumarate 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50 0.29 nM) and AXL (IC50 0.73 nM) inhibitor for the treatment of relapsed or refractory FLT3 mutant AML. Purity 98.07%
Apexbio Technology LLC 1 2-Dipalmitoyl-sn-glycero-3-PC 100mg
1 2-Dipalmitoyl-sn-glycero-3-phosphorylcholine (DPPC) is a zwitterionic glycerophospholipid commonly used to form lipid monolayers bilayers and liposomes for various applications DPPC-liposomes effectively serve as delivery vehicles to induce immune responses against GSL antigens in mice
Apexbio Technology LLC SM-102 100mg
SM-102 is an amino cationic lipid specifically used to form lipid nanoparticles (LNPs) to enhance the efficiency of mRNA delivery into cells Studies have shown that SM-102 effectively modulates erg-mediated potassium currents (i erg) in GH cells at concentrations ranging from 100 to 300 M thereby regulating specific signaling pathways Its applications include research on drug delivery technologies for mRNA therapies and vaccine development
Apexbio Technology LLC PD153035 hydrochloride 153436-54-5 10mM (in 1mL DMSO)
PD153035 hydrochloride (CAS 153436-54-5) is a small molecule inhibitor that targets the epidermal growth factor receptor (EGFR) tyrosine kinase by competitively binding to the ATP-binding site thereby suppressing EGFR kinase activity with an IC50 of 0 025 nM In various EGFR-overexpressing human tumor cell lines including A431 Difi DU145 MDA-MB-468 ME180 and C4i PD153035 inhibits EGF-dependent EGFR phosphorylation and subsequently reduces cell proliferation and colony formation with IC50 values ranging from 0 22 M to 2 5 M Additionally the compound partially inhibits the related HER2/neu receptor supporting its use in research exploring EGFR and HER2 signaling pathways and targeted cancer therapies
Medchemexpress LLC 1,3-Dioxolane-4-ethanol, 2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl- | 1190203-55-4 | C41H74O3 | 250 MG
LNP Lipid-7 is a cationic lipid used to prepare lipid nanoparticles (LNPs) for the delivery of drugs, such as nucleic acids.
- Used to prepare lipid nanoparticles (LNPs) for drug delivery
- Cationic lipid
- Purity of 95.0%
- Molecular weight of 615.02
- Liquid appearance, colorless to light yellow
- Density of 0.901 g/cm³
Medchemexpress LLC 7,8-Dihydro-L-biopterin | 6779-87-9 | 96.5% | 239.23 | 10 MG
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. It is the main metabolite of 4-amino-tetrahydro-L-biopterin and undergoes photooxidation to form biopterin. It promotes the conversion of nitric oxide synthase to a superoxide-producing form, increasing oxidative stress levels in the renal outer medulla and inducing apoptosis.
- Nos uncoupling inducer
- Blood-brain barrier permeability
- Reduced non-conjugated pteridine
- Main metabolite of 4-amino-tetrahydro-L-biopterin
- Sensitive to the inhibitory effect of SOD
Medchemexpress LLC PI-103 hydrochloride | 371935-79-4 | MFCD10687102 | ≥98.0% | 384.82 g/mol | C19H17ClN4O3 | 1 ML
PI-103 hydrochloride is a small-molecule research reagent that functions as a dual inhibitor of PI3K and mTOR. Supplied as a hydrochloride salt, it is used in cellular and biochemical studies to probe PI3K/mTOR signaling pathways and can be purchased as a solid or as a pre-made 10 mM solution in DMSO for immediate use.
- Dual PI3K and mTOR inhibition for pathway studies.
- Available as a 10 mM solution in DMSO for convenient use.
- Also available as a solid for custom formulation.
- High purity suitable for research (≥98%).
- Applicable to cellular and biochemical assay workflows.
Medchemexpress LLC Clobenpropit dihydrobromide | 145231-35-2 | MFCD00467655 | 99.8% | 470.65 g·mol⁻¹ | C14H19Br2ClN4S | 10 MG
Clobenpropit dihydrobromide is the dihydrobromide salt of clobenpropit, a histamine receptor ligand used for laboratory research. It acts as a potent histamine H3 receptor antagonist/inverse agonist and a partial H4 agonist, with reported additional binding to 5-HT3 and α2 adrenoceptors. The compound is supplied as a high-purity solid for receptor pharmacology and binding studies.
- High purity (99.76%).
- Molecular formula C14H19Br2ClN4S; molecular weight 470.65 g·mol⁻¹.
- CAS number 145231-35-2.
- Potent H3 antagonist/inverse agonist (pEC50 ~8.07).
- Suitable for receptor pharmacology and binding assays.
- Available in small research quantities (e.g., 10 MG).
Cayman Chemical Dimebolin hydrochloride
A neuroprotective agent; binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-ARs, imidazoline I2 receptors, and 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors (Kis = 8-313 nM); inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 μM, respectively); inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease at 50 μM; inhibits cell death induced by amyloid-β (25-35) in cerebellar granule cells at 25 μM; inhibits decreases TWAA acquisition in a rat model of AF64A-induced Alzheimer’s disease at 1 mg/kg
Apexbio Technology LLC Xamoterol hemifumarate 73210-73-8 25mg
Xamoterol hemifumarate (CAS 73210-73-8) is a selective 1-adrenergic receptor agonist targeting cardiac 1 receptors It is designed to activate 1-adrenergic signaling pathways thereby modulating myocardial function and cardiac electrophysiological processes Xamoterol hemifumarate exerts its biological activity primarily through 1-adrenergic receptor stimulation influencing downstream intracellular signaling cascades related to cardiac rhythm regulation In experimental settings it is utilized in vitro with cellular cardiac models and in vivo with animal models to assess 1-adrenergic receptor-mediated effects particularly in the interaction with cardiac ion channels such as the rapid delayed rectifier potassium current (IKr) Based on these pharmacological properties Xamoterol hemifumarate holds research potential in the study of arrhythmogenesis mechanisms and cardiac electrophysiology
Apexbio Technology LLC Xamoterol hemifumarate 73210-73-8 10mg
Xamoterol hemifumarate (CAS 73210-73-8) is a selective 1-adrenergic receptor agonist targeting cardiac 1 receptors It is designed to activate 1-adrenergic signaling pathways thereby modulating myocardial function and cardiac electrophysiological processes Xamoterol hemifumarate exerts its biological activity primarily through 1-adrenergic receptor stimulation influencing downstream intracellular signaling cascades related to cardiac rhythm regulation In experimental settings it is utilized in vitro with cellular cardiac models and in vivo with animal models to assess 1-adrenergic receptor-mediated effects particularly in the interaction with cardiac ion channels such as the rapid delayed rectifier potassium current (IKr) Based on these pharmacological properties Xamoterol hemifumarate holds research potential in the study of arrhythmogenesis mechanisms and cardiac electrophysiology
Apexbio Technology LLC Tacrine hydrochloride 1684-40-8 10mM (in 1mL H2O)
Tacrine hydrochloride (CAS 1684-40-8) is a small molecule inhibitor of cholinesterases exhibiting potent inhibitory activity against both acetylcholinesterase (AChE IC 31 nM) and butyrylcholinesterase (BChE IC 25 6 nM) in vitro Additionally it has been shown to inhibit N-methyl-D-aspartate receptors (NMDARs) with an IC of approximately 26 M By modulating both cholinergic and glutamatergic signaling pathways tacrine hydrochloride is frequently employed in studies investigating the molecular mechanisms underlying Alzheimer s disease and exploring potential therapeutic strategies for neurodegenerative disorders
Apexbio Technology LLC KN-93 hydrochloride 1956426-56-4 1mg
KN-93 hydrochloride (CAS 1956426-56-4) is a selective inhibitor of Ca2 /calmodulin-dependent protein kinase II (CaMK II) binding competitively at the calmodulin site with a reported Ki of 0 37 M and an IC50 of 370 nM In isolated gastric parietal cells KN-93 suppresses acid secretion stimulated by carbachol and histamine with IC50 values of 0 15 M and 0 3 M respectively and inhibits mucin-stimulated aminopyrine uptake (IC50 0 6 M) Additionally KN-93 shows inhibitory activity against H /K -ATPase and directly blocks voltage-gated potassium (Kv) channels by promoting C-type inactivation KN-93 is widely used to probe CaMK II signaling and its downstream physiological effects in cellular and electrophysiological studies