Piperidines
Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.4% | 10 MG
(R,R)-GSK321 is an inhibitor of wild-type isocitrate dehydrogenase 1 (WT IDH1) with an IC50 value of 120 nM. This compound also acts as a mutant R132H IDH1 inhibitor and is an isomer of GSK321 with some wild-type cross-reactivity. It has a molecular weight of 501.55 and a chemical formula of C28H28FN5O3. This product appears as a white to off-white solid.
- Inhibits wild-type isocitrate dehydrogenase 1 (WT IDH1)
- IC50 value of 120 nM for WT IDH1
- Acts as a mutant R132H IDH1 inhibitor
- Isomer of GSK321 with some wild-type cross-reactivity
- Dose-dependently decreases reductive glutaminolysis in A-498 cells (0.1-3 μM for 5 hours)
- For research use only, not for patient use
Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.4% | 50 MG
(R,R)-GSK321 is a potent inhibitor of wild-type isocitrate dehydrogenase 1 (WT IDH1) with an IC50 value of 120 nM. This compound also acts as a mutant R132H IDH1 inhibitor, being an isomer of GSK321 with some wild-type cross-reactivity.
- Potent WT IDH1 inhibitor
- IC50 value of 120 nM for WT IDH1
- Mutant R132H IDH1 inhibitor
- Decreases reductive glutaminolysis in A-498 cells
- For research use only
- Associated with cancer, cancer targeted therapy, and cancer metabolism research
- Classified as a metabolic enzyme/protease and isocitrate dehydrogenase (IDH) inhibitor
Medchemexpress LLC HY-111454 5mg Medchemexpress, SR17018 CAS:2134602-45-0 Purity:>98%
Medchemexpress, HY-111454 5mg SR17018 CAS:2134602-45-0 SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 5 MG
pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 5 MG
Medchemexpress LLC (S,R)-GSK321 | 1816272-18-0 | 98.6% | 10 MG
(S,R)-GSK321 is a potent and selective mutant IDH1 inhibitor, specifically the (S,R)-enantiomer of GSK321. It demonstrates high selectivity over IDH2 and induces a decrease in intracellular 2-HG. This compound abrogates the myeloid differentiation block and promotes granulocytic differentiation in leukemic blasts and immature stem-like cells. It is suitable for research into acute myeloid leukemia (AML) and other cancers.
- Potent, selective mutant IDH1 inhibitor
- IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively
- Greater than 100-fold selectivity over IDH2
- Induces a decrease in intracellular 2-HG
- Abrogates the myeloid differentiation block
- Induces granulocytic differentiation in leukemic blasts and immature stem-like cells
- Used for research of acute myeloid leukemia (AML) and other cancers
Medchemexpress LLC HY-10017 10mg Medchemexpress, SCH 546738 CAS:906805-42-3 Purity:>98%
Medchemexpress, HY-10017 10mg SCH 546738 CAS:906805-42-3 SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 23210-58-4 | 4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemi((2R,3R)-2,3-dihydroxysuccinate) | MFCD26142666 | 100mg
ChemScene | 4-(p-Tolyl)oxazole | 100mg | 768994226 | CS-0616874 | 54289-71-3 | MFCD10478287 | 159.188 | C10H9NO
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Aobchem 3-Fluoro-4-(piperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 874289-10-8 | C12H15BFNO3 | 5g
3-Fluoro-4-(piperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 874289-10-8 | C12H15BFNO3 | 5g
Medchemexpress LLC Dimethyl fumarate | 624-49-7 | MFCD00064438 | 99.9% | 144.13 | C6H8O4 | 10 MG
Dimethyl fumarate is an analytical reference standard supplied as a white to off-white solid with high purity for research and analytical applications. It is commonly used in studies of Nrf2 activation, oxidative stress pathways, and multiple sclerosis research.
- High purity (99.85%).
- Solid, white to off-white physical form.
- Chemical formula C6H8O4 and molecular weight 144.13 g/mol.
- Available in small package sizes, including 10 mg.
- Intended for research and analytical use in pathway and disease studies.
Medchemexpress LLC Dimethyl fumarate | 624-49-7 | 100.0% | 144.13 | 25 MG
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator that induces upregulation of antioxidant gene expression. It induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research. It also acts as an immune modulator and inducer of the antioxidant response, suppressing HIV replication and neurotoxin release.
- Orally active and brain-penetrant Nrf2 activator
- Induces upregulation of antioxidant gene expression
- Induces necroptosis in colon cancer cells
- Induces cell autophagy
- Used for multiple sclerosis research
- Immune modulator
- Inducer of the antioxidant response
- Suppresses HIV replication and neurotoxin release
- Inhibits dendritic cell (DC) maturation
- Impairs NF-κB signaling
Medchemexpress LLC HY-15243 5mg Medchemexpress, Capromorelin (Tartrate) CAS:193273-69-7 Purity:>98%
Medchemexpress, HY-15243 5mg Capromorelin (Tartrate) CAS:193273-69-7 Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 861998-00-7 | Medchem Express | Anamorelin (hydrochloride) | 5mg | 446264500 | HY-14734A | 1166.35 | C62H86Cl2N12O6
Medchem Express | Anamorelin (hydrochloride) | 5mg | 446264500 | HY-14734A | 861998-00-7 | 1166.350 | C62H86Cl2N12O6
Aobchem 3-(Piperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 850568-34-2 | C12H16BNO3 | 25g
3-(Piperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 850568-34-2 | C12H16BNO3 | 25g
Aobchem 2-Fluoro-4-(piperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 874289-26-6 | C12H15BFNO3 | 5g
2-Fluoro-4-(piperidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 874289-26-6 | C12H15BFNO3 | 5g