Piperidines
Medchemexpress LLC HY-100748 5mg Medchemexpress, CXD101 CAS:934828-12-3 Purity:>98%
Medchemexpress, HY-100748 5mg CXD101 CAS:934828-12-3 CXD101 is a class I-selective HDAC inhibitor (HDAC1 ( IC 50 , 63 nM), HDAC2 ( IC 50 , 570 nM), HDAC3 ( IC 50 , 550 nM). CXD101 has no activity against HDAC class II [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Pomalidomide-C12-NH2 hydrochloride | 2862774-02-3 | 97.1% | C25H37ClN4O4 | 10MG
Pomalidomide-C12-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that serves as the Cereblon-binding component in PROTAC constructs targeting KRAS G12C. Supplied as the hydrochloride salt, it is provided as a solid for use in targeted protein degradation research and biochemical assay development.
- E3 ligase ligand-linker conjugate suitable for Cereblon-based PROTAC design.
- Hydrochloride salt form; solid, light yellow to green yellow appearance.
- High purity (97.1%).
- Molecular formula C25H37ClN4O4; molecular weight 493.04 g·mol⁻1.
- Recommended storage at -20°C; protect from light.
- Available in small research sizes (5-500 mg).
Selleck Chemical LLC Encenicline (EVP-6124) hydrochloride S2957-5mg
Encenicline (EVP-6124) hydrochloride is a selective 7 nicotinic acetylcholine receptor partial agonist improves memory performance by potentiating the acetylcholine response of 7 nicotinic acetylcholine receptors
Apexbio Technology LLC CHIR-124 405168-58-3 5mg
CHIR-124 (CAS 405168-58-3) is a selective small-molecule inhibitor of checkpoint kinase 1 (Chk1) with an IC50 of 0 3 nM demonstrating over 2 000-fold selectivity versus Chk2 (IC50 0 7 M) It also inhibits PDGFR and FLT3 with nanomolar potency CHIR-124 abrogates DNA damage-induced S and G2-M cell cycle checkpoints and enhances mitotic cell death particularly in p53-deficient tumor cells In preclinical studies CHIR-124 potentiates the cytotoxicity of topoisomerase I poisons such as camptothecin and irinotecan and increases radiosensitivity in various p53-mutant human tumor models This compound is widely used to investigate DNA damage response mechanisms and potential combination strategies in cancer therapy research
Apexbio Technology LLC Domperidone 57808-66-9 100mg
Domperidone is a small-molecule antagonist targeting the dopamine D2 receptor It is designed to inhibit peripheral dopamine receptors thereby enhancing gastrointestinal motility and accelerating gastric emptying Domperidone exerts its biological activity primarily through peripheral D2 receptor antagonism Based on these pharmacological properties domperidone holds research potential in the investigation and management of gastroparesis and as a comparative compound for mechanistic studies of gastric motility disorders
Apexbio Technology LLC BMS-790052 dihydrochloride 1009119-65-6 5mg
BMS-790052 dihydrochloride (CAS 1009119-65-6) is a small-molecule inhibitor targeting hepatitis C virus (HCV) nonstructural protein 5A (NS5A) a zinc-binding protein essential for viral RNA replication It is designed to suppress viral replication by specifically interacting with NS5A BMS-790052 dihydrochloride exerts its biological activity primarily through NS5A inhibition In cell-based replicon assays using genotypes 1a 1b and hybrid genotype 5a BMS-790052 dihydrochloride demonstrates potent inhibitory activity with EC50 values ranging from approximately 9 to 50 pM for genotypes 1a and 1b and from 3 to 7 pM for genotype 5a hybrid replicons Based on these pharmacological properties BMS-790052 dihydrochloride holds research potential in antiviral studies targeting diverse HCV genotypes
Apexbio Technology LLC SAR7334 1333210-07-3 2mg
SAR7334 (CAS 1333210-07-3) is a small molecule inhibitor that selectively targets the transient receptor potential cation channel subfamily C member 6 (TRPC6) By inhibiting TRPC6-mediated calcium influx SAR7334 is utilized to investigate TRPC6-related signal transduction pathways in cellular and preclinical studies This compound serves as a valuable tool for elucidating the role of TRPC6 in pathophysiological processes including those related to kidney function and vascular regulation Its application aids in advancing the understanding of TRPC6-associated diseases and potential therapeutic interventions
Apexbio Technology LLC HTH-01-015(Synonyms: HTH01015, WZ4003, NUAK1 inhibitor WZ4003, NUAK1-IN-1, NUAK1 inhibitor, WZ-4003), 10mg, CAS: 1613724-42-7.
HTH-01-015 (CAS 1613724-42-7) is a highly selective inhibitor targeting the NUAK1 kinase exhibiting potent inhibitory activity with an IC50 of approximately 100 nM It specifically blocks NUAK1-mediated phosphorylation of MYPT1 at Ser445 with negligible off-target effects among a comprehensive panel of 139 other kinases Cellular studies demonstrate that treatment with HTH-01-015 reduces migration of mouse embryonic fibroblasts (MEFs) suppresses proliferation in U2OS and MEF cell lines at concentrations around 10 M and significantly inhibits invasion of U2OS cells within 3D Matrigel transwell assays This compound serves as a useful research tool for investigating NUAK1-related signaling pathways in cancer biology and cellular dynamics
Medchemexpress LLC BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 | 50 MG
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), with IC50 values of 6 nM in intracellular pH recovery (pHi) assays and 31 nM in human platelet swelling assays. It demonstrates over 30-fold selectivity against NHE2 and shows no measurable inhibitory activity against the NHE3 isoform.
- Decreases autophagy in HTR-8/SVneo cells and reduces human sperm pHi.
- Prolongs Ca2+ recovery in hiPSC-CMs; potent in ischemia-reperfusion injury models.
- Low drug-drug interaction (DDI) potential; excellent pharmacokinetics in rat and dog.
- Off-white to light yellow solid appearance.
- Soluble in DMSO (100 mg/mL) and H2O (4.17 mg/mL).
- Solid storage at 4°C; stock solutions at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC HY-100388 5mg Medchemexpress, SHP099 CAS:1801747-42-1 Purity:>98%
Medchemexpress, HY-100388 5mg SHP099 CAS:1801747-42-1 SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC 50 of 70 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 25 MG
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It has IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases the expression of cleavaged PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).
- Potent and selective IRAK1 PROTAC degrader
- IRAK1 IC50: 72 nM
- IRAK4 IC50: 443 nM
- VHL FP IC50: 1071 nM
- Induces apoptosis and increases cleaved PARP expression
- Decreases IRAK1, p-IKBα, and pSTAT3(Tyr705) expression
- Degrades IRAK1 protein with a DC50 value of 3 nM in a dose-dependent manner
- Demonstrated decreased IRAK1 expression in HEK293T cells (1.5-10000 nM)