Piperidines
Medchemexpress LLC Avibactam sodium | 1192491-61-4 | 99.99% | 287.23 | 1 ML
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor. It inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively. This molecule exhibits little antibacterial activity and effectively inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases. It is intended for research use only.
- Covalent and reversible non-β-lactam β-lactamase inhibitor
- Inhibits β-lactamase TEM-1 and CTX-M-15
- Exhibits little antibacterial activity
- Inhibits class A and C β-lactamases
- Not effective against metallo types and Acinetobacter OXA carbapenemases
- Intended for research use only
Medchemexpress LLC Levobupivacaine hydrochloride | 27262-48-2 | 99.9% | 200 MG
Levobupivacaine hydrochloride is a long-acting amide local agent primarily used for pain management. It functions by reversibly blocking neuronal sodium channels, which inhibits impulse transmission in various tissues, including cardiovascular. This compound is metabolized by hepatic cytochrome P450 enzymes and can also induce ferroptosis through miR-489-3p/SLC7A11 signaling in gastric cancer. It is intended for research use only.
- Long-acting amide local agent
- Suppresses or relieves pain
- Reversibly blocks neuronal sodium channels
- Inhibits impulse transmission and conduction in cardiovascular and other tissues
- Metabolized by hepatic cytochrome P450 enzymes
- Can induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer
- For research use only
Medchemexpress LLC IOWH-032 | 1191252-49-9 | 99.6% | 545.18 | 500 MG
IOWH-032 is a synthetic anti-secretory molecule and a potent CFTR inhibitor with an IC50 value of 8 μM. It also functions as an anti-diarrheal agent, making it suitable for cholera, secretory diarrhea, and general diarrhea research.
- Potent CFTR inhibitor with an IC50 value of 8 μM
- Functions as an anti-diarrheal agent
- Increases ACE-2 expression in SARS-CoV-2 infected CFBE41o-WT cells
- Suitable for in vitro and in vivo studies
- Available with detailed datasheet and safety information
eMolecules 850040-18-5 | 6-(1-Azepanyl)-3-pyridinamine | Combi-Blocks, Inc. | MFCD08700222 | 191.278 | C11H17N3 | 96.000 | Nc1ccc(nc1)N1CCCCCC1 | 25g | 603130398
6-(1-Azepanyl)-3-pyridinamine | Combi-Blocks, Inc. | 850040-18-5 | MFCD08700222 | 191.278 | C11H17N3 | 96.000 | Nc1ccc(nc1)N1CCCCCC1 | 25g | 603130398
Apexbio Technology LLC Nelfinavir Mesylate 159989-65-8 5mg
Nelfinavir Mesylate (CAS 159989-65-8) is a small-molecule inhibitor targeting HIV-1 protease It is designed to inhibit the enzymatic processing of gag and gag-pol precursor polyproteins thereby interfering with viral maturation Nelfinavir Mesylate exerts its biological activity primarily through inhibition of HIV-1 protease activity In cell-based antiviral assays using HIV-1-infected cells Nelfinavir Mesylate demonstrates inhibition of viral replication with EC50 values ranging from 14 nM to 43 nM Based on these pharmacological properties Nelfinavir Mesylate holds research potential in preclinical studies investigating HIV replication mechanisms therapeutic resistance profiles and combination antiretroviral drug strategies
Apexbio Technology LLC Levobupivacaine HCl 27262-48-2 10mM (in 1mL DMSO)
Levobupivacaine HCl (CAS 27262-48-2) is the optically pure S(-)-enantiomer of bupivacaine and functions as a long-acting local anesthetic It exerts its effects by reversibly blocking voltage-gated sodium channels in neuronal cell membranes thereby inhibiting the initiation and propagation of action potentials This action results in a localized loss of sensory and motor function Levobupivacaine HCl is widely utilized in biomedical research to study nociceptive pathways investigate anesthetic pharmacology and evaluate neurotoxicity or cardiotoxicity profiles of local anesthetics in both in vitro and in vivo models
Medchemexpress LLC Ropivacaine (hydrochloride) | 98717-15-8 | 99.5% | 1 ML
Ropivacaine hydrochloride is a potent sodium channel blocker that reversibly inhibits sodium ion influx in nerve fibers to block impulse conduction. It also acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. It is widely used for neuropathic pain management in vivo.
- Potent sodium channel blocker
- Reversibly inhibits sodium ion influx
- Inhibits K2P TREK-1 with an IC50 of 402.7 μM
- Used for neuropathic pain management in vivo
- Effectively blocks neuropathic pain via epidural administration
- Prevents pressure-induced lung edema and associated hyperpermeability
Selleck Chemical LLC Ropivacaine
Ropivacaine is a member of the amino amide class of local anesthetics
Medchemexpress LLC Nelfinavir mesylate | 159989-65-8 | C33H49N3O7S2 | 1 ML
Nelfinavir mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) used for HIV infection. It also acts as a broad-spectrum anticancer agent.
- Potent HIV-1 protease inhibitor (Ki=2 nM)
- Broad-spectrum anticancer agent
- Inhibits proliferation of multiple myeloma cells
- Triggers apoptosis in myeloma cell lines
- Decreases phosphorylation of AKT
- Activates cleavage of caspase-3
- SARS-CoV 3CLpro inhibitor (IC50 = 35.93 μM)
Medchemexpress LLC Nelfinavir | 159989-64-7 | 98.65% | 567.78 | 50 MG
Nelfinavir is a potent, orally bioavailable HIV-1 protease inhibitor and a broad-spectrum anticancer agent. It is intended for research use only.
- Potent and orally bioavailable HIV-1 protease inhibitor
- Broad-spectrum anticancer agent
- Inhibits proliferation of multiple myeloma cells
- Induces apoptosis
- Decreases phosphorylation of AKT
Apexbio Technology LLC Avibactam sodium 1192491-61-4 5mg
Avibactam sodium (1192491-61-4) is a small-molecule inhibitor targeting bacterial -lactamase enzymes including CTX-M-15 and TEM-1 It is designed to inhibit -lactamase activity thereby preventing the hydrolysis of -lactam antibiotics Avibactam sodium exerts its biological activity primarily through reversible covalent non- -lactam inhibition of its targets In in vitro studies avibactam sodium demonstrates inhibitory activity with IC50 values of 5 nM for CTX-M-15 and 8 nM for TEM-1 Based on these pharmacological properties avibactam sodium holds research potential in studies of combination therapy for bacterial infections involving -lactamase-producing Gram-negative pathogens
Apexbio Technology LLC Levobupivacaine HCl 27262-48-2 50mg
Levobupivacaine HCl (CAS 27262-48-2) is the optically pure S(-)-enantiomer of bupivacaine and functions as a long-acting local anesthetic It exerts its effects by reversibly blocking voltage-gated sodium channels in neuronal cell membranes thereby inhibiting the initiation and propagation of action potentials This action results in a localized loss of sensory and motor function Levobupivacaine HCl is widely utilized in biomedical research to study nociceptive pathways investigate anesthetic pharmacology and evaluate neurotoxicity or cardiotoxicity profiles of local anesthetics in both in vitro and in vivo models
Chembridge Corporation CARBOX. ACID 4401226-01, 1GR
4-(1-piperidinylmethyl)benzoic acid hydrate; CAS: 159691-33-5
Chembridge Corporation 3-(PIPERIDIN-1-YLMETHYL)ANILIN
3-(piperidin-1-ylmethyl)aniline; CAS: 93138-55-7
Accela Chembio Inc 3-(1-piperidylmethyl)aniline | 5g | 93138-55-7 | MFCD04114502 | 95+% | Shelf Life: 1080 Days | Light Sensitive/nitrogen Or Argon/+4
3-(1-piperidylmethyl)aniline | 5g | 93138-55-7 | MFCD04114502 | 95+% | Shelf Life: 1080 Days | Light Sensitive/nitrogen Or Argon/+4