Pyridines and derivatives
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- (7)
- (5)
- (1)
- (1)
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- (2)
- (1)
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- (6)
- (7)
- (12)
- (1)
- (1)
- (39)
- (1)
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- (11)
- (4)
- (2)
- (2)
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- (1)
- (1)
- (1)
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- (1)
- (1)
- (1)
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- (1)
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Medchemexpress LLC CCR2-RA-[R] | 512177-83-2 | 99.7% | 351.80 | 10 MG
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CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2), inhibiting it non-competitively with an IC50 of 103 nM. It functions by blocking activation-associated conformational changes and the formation of the G protein-binding interface.
- Binding pocket has balanced hydrophobic and polar features, favoring druggability
- Displaces [125I]CCL2 from CCR2 with pIC50 of 6.1
- pKD values for CCR2 and CCR5 are 8.8±0.1 and 7.0±0.1, respectively
- Soluble in DMSO (37.5 mg/mL)
- Stable as powder at -20°C for 3 years or 4°C for 2 years
- Stable in solvent at -80°C for 2 years or -20°C for 1 year
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC 2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo- | 14003-96-4 | 99.65% | 204.18 | 10 MG
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4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α. It inhibits Xbp1 splicing in ER stressed cultured cells in a concentration-dependent manner. This compound plays a role in cellular and in vivo research by modulating various biological activities related to ER stress and immune responses.
- Inhibits Xbp1 splicing in ER stressed cultured cells
- Prevents XBP1 mRNA splicing in response to ER stress
- Significantly inhibits IL-4, IL-5, and IL-13 production by CD4+ T cells
- Reduces atherosclerotic lesion area in ApoE-/- mice
- Mitigates plaque development
- Suppresses passive cutaneous anaphylaxis in mice
- Reverses ER stress-dependent loss of RIDD targets
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Medchemexpress LLC M199 100mg | 1051933-86-8 | 100 MG
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M199 is a small-molecule inhibitor of Toll-like receptor 3 (TLR3) and Toll-like receptor 9 (TLR9) signaling that induces secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNFα) in human peripheral blood mononuclear cells. It is used as a selective inducer/modulator of immune responses in research settings.
- Inhibits TLR3 and TLR9 signaling pathways
- Induces IL-6, IL-8, and TNFα secretion in human PBMCs
- Useful for studying innate immune activation and cytokine responses
- High chemical purity for reproducible experimental results
- Available in small research quantities including 100 mg
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Medchemexpress LLC 2-amino-N-(4-chlorophenyl)benzamide | 4943-86-6 | MFCD00170586 | 98.9% | 246.69 g/mol | C13H11ClN2O | 100 MG
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2-amino-N-(4-chlorophenyl)benzamide is a research-grade selective cyclooxygenase-1 (COX-1) inhibitor supplied as a solid for biochemical and pharmacological studies.
- Selective cyclooxygenase-1 inhibitor suitable for COX-1 focused assays.
- High purity (~98.9%) appropriate for analytical and biological testing.
- Molecular weight 246.69 g/mol; formula C13H11ClN2O.
- Solid form with recommended storage at 4°C and protection from light; solution stability: -80°C (6 months) or -20°C (1 month).
- Available in multiple pack sizes, including 100 mg and solution aliquots for screening.
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Medchemexpress LLC Satigrel 100mg | 111753-73-2 | 100 MG
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Satigrel is a research-grade small-molecule inhibitor of prostaglandin-endoperoxide synthase 1 (PGHS1/COX-1) used to study platelet aggregation and prostaglandin signaling in vitro and preclinical assays.
- Selective PGHS1 (COX-1) inhibitor
- Reported IC50 for PGHS1: 0.081 μM
- Also inhibits PGHS2 and several phosphodiesterase isoforms
- Molecular formula C20H19NO4 and molecular weight 337.37 g/mol
- High purity (99.9%) suitable for research applications
- Available in multiple pack sizes, including 100 MG
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Aobchem AOBCHEM
5001012782 5- 4-BROMOPHENYL -1H-TETRAZOLE
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Aobchem AOBCHEM
5001012635 2-METHOXYCARBONYLTHIOPHENE-3-B
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Medchemexpress LLC Dansyl-L-phenylalanine | 1104-36-5 | MFCD00037730 | >98.0% | 398.48 g/mol | C21H22N2O4S | 5 G
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Dansyl-L-phenylalanine is a dansylated derivative of L-phenylalanine that contains a 5-dimethylaminonaphthalene-1-sulfonyl (dansyl) fluorophore attached to the amino group. It is used as a fluorescent probe or label in biochemical and analytical applications and is supplied as a solid.
- Fluorescent dansyl label for detection and spectroscopy
- Used in biochemical assays and probe synthesis
- CAS 1104-36-5; chemical formula C21H22N2O4S
- Molecular weight ~398.48 g/mol
- Typical purity >98.0%
- Common pack sizes: 1 G, 5 G, 10 G
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eMolecules 38749-79-0 | 3-Bromo-2-methylpyridine | Accela ChemBio (ASD) | MFCD00191224 | 172.025 | C6H6BrN | 97.000 | Cc1ncccc1Br | 25g | 449059767
3-Bromo-2-methylpyridine | Accela ChemBio (ASD) | 38749-79-0 | MFCD00191224 | 172.025 | C6H6BrN | 97.000 | Cc1ncccc1Br | 25g | 449059767
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Medchemexpress LLC Lotilaner 50mg | 1369852-71-0 | 50 MG
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Lotilaner is an isoxazoline-class ectoparasiticide used as a research compound. It acts as a potent non-competitive antagonist of invertebrate GABACl receptors and is supplied as a high-purity solid suitable for in vitro and in vivo studies.
- Purity 99.84% (HPLC)
- Chemical formula C20H14Cl3F6N3O3S; molecular weight 596.76
- CAS number 1369852-71-0
- Available in small-mass packages including a 50 mg pack
- Powder storage: -20°C for long-term stability; in solvent: store at -80°C
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eMolecules 90213-66-4 | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | Accela ChemBio (ASD) | MFCD08059278 | 188.010 | C6H3Cl2N3 | 97.000 | Clc1nc(Cl)c2cc[nH]c2n1 | 1g | 487913703
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine | Accela ChemBio (ASD) | 90213-66-4 | MFCD08059278 | 188.010 | C6H3Cl2N3 | 97.000 | Clc1nc(Cl)c2cc[nH]c2n1 | 1g | 487913703
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Medchemexpress LLC Peroxiredoxin 5 Anti | 100UL
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Peroxiredoxin 5 Anti | 100UL
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MEDCHEMEXPRESS LLC VPS34-PIK-III 5MG
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501872732 VPS34-PIK-III 5MG
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Medchemexpress LLC Fenretinide | 65646-68-6 | MFCD00792674 | C26H33NO2 | 25 MG
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Fenretinide (4-HPR) is a synthetic retinoid derivative that binds to retinoic acid receptors (RAR) at concentrations necessary to induce cell death. It is intended for research use only.
- Exerts acute and long-term antitumor activity in selected T-ALL cell lines.
- Inhibits DES activity in CCRF-CEM leukemia cells, leading to increased dhCer content.
- Protects insulin signaling by preventing lipid-induced reductions in insulin-stimulated glucose uptake.
- Inhibits OVCAR-5 cell proliferation and viability.
- Prevents endothelial cells from forming tubes at 1 microM.
- Selectively inhibits ceramide accumulation in HFD-fed male C57Bl/6 mice.
- Improves glucose tolerance and insulin sensitivity in mice.
- Ketoconazole can increase 4-HPR plasma levels in NOD/SCID mice.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000381868 JHU37160 10MM 1ML
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