Pyridines and derivatives
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Selleck Chemical LLC Pazopanib S3012-1g
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Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms/CSF1R with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM in cell-free assays respectively Pazopanib induces cathepsin B activation and autophagy
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Medchemexpress LLC 11-Methoxyyangonin 5mg | 5MG
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11-Methoxyyangonin 5mg | 5MG
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Gold Biotechnology Inc DNase I Bovine Pancreas
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DNase I (Deoxyribonuclease I) is a dialyzed lyophilized powder from bovine pancreas that has been purified by chromatography
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Medchemexpress LLC NORHARMANE 1G | 1G
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NORHARMANE 1G | 1G
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Selleck Chemical LLC BIBR 1532 S1186-1g
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BIBR 1532 is a potent selective non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay No inhibition of DNA and RNA polymerases including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase BIBR 1532 induces apoptosis in cancer cells
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TARGETMOL CHEMICALS INC CCG215022 2MG
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Also available in 1 mL, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 uM for GRK2, 0.38±0.06 uM for GRK5, and 3.9±1 uM for GRK1. Purity 97.46%
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TARGETMOL CHEMICALS INC DEPTOR-IN-1 1MG
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.DEPTOR-IN-1 is an inhibitor of DEPTOR with a Kd of 9.3 uM. Purity 97.84%
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Selleck Chemical LLC Vorinostat (SAHA) S1047-2g
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Vorinostat (SAHA) is an HDAC inhibitor with IC50 of 10 nM in a cell-free assay Vorinostat abrogates productive HPV-18 DNA amplification
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Medchemexpress LLC Secretin canine TF | 25MG
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Secretin canine TF | 25MG
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Cambridge Isotope Laboratories 1 3 7 9-TetraCDD (unlabeled) 25 ng/mL in nonane 0 2 mL
1 3 7 9-TetraCDD (unlabeled) 25 ng/mL in nonane 0 2 mL
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Cambridge Isotope Laboratories Nitroglycerin (unlabeled) 1 mg/mL in acetonitrile 1 mL
Nitroglycerin (unlabeled) 1 mg/mL in acetonitrile 1 mL
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Medchemexpress LLC Smart1 (PROTAC Smurf1 degrader) | 99.9% | 753.76 | C40H35N9O7 | 5mg
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SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1 SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models (Blue CRBN ligand Black linker Pink Smurf1 ligand (Smurf1-L)) [1] br/
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Medchemexpress LLC Nrf2 activator-2 | 2770448-53-6 | 99.2% | C20H17BrO3 | 25 MG
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Nrf2 activator-2 (compound O15), an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM in 293 T cells. This compound effectively inhibits the interaction between Keap1 and Nrf2, thereby activating Nrf2 and leading to a marked decrease in the level of ubiquitinated Nrf2 in cells.
- Potent Nrf2 agonist.
- Effectively inhibits Keap1-Nrf2 interaction.
- Activates Nrf2 signaling pathway.
- Decreases ubiquitinated Nrf2 levels.
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Medchemexpress LLC GSTP1 Human His 100ug
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Recombinant human glutathione S-transferase P1 (GSTP1) with an N-terminal His tag, expressed in E. coli and supplied as a highly purified protein for biochemical and structural research. It is suitable for enzyme activity assays, antibody validation, and other applications requiring purified human GSTP1.
- Recombinant human GSTP1 with N-terminal His tag.
- Expressed in E. coli and purified to >95% by reducing SDS-PAGE.
- Approximate molecular weight 25-30 kDa.
- Available in multiple sizes, including 100 μg.
- Store frozen at -20°C; reconstituted material is stable at 4°C for 1 week.
- Recommended reconstitution ≥100 μg/mL in ddH2O and addition of carrier protein for long-term storage.
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Apexbio Technology LLC GANT61 500579-04-4 25mg
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GANT61 (CAS 500579-04-4) is a selective inhibitor targeting GLI transcription factors downstream effectors of the canonical Hedgehog (HH) signaling cascade HH signaling mediates crucial developmental processes and differentiation while abnormal activation of GLI transcription factors (GLI1 GLI2) contributes to oncogenesis GANT61 inhibits GLI-mediated transcriptional activity demonstrated by inhibition of cell proliferation (IC50 values around 7 96 13 56 M) and induction of cell-cycle arrest and apoptosis in cancer cell lines (e g neuroblastoma rhabdomyosarcoma) In vivo studies using xenograft tumor models indicate suppression of tumor growth highlighting GANT61 s role in oncology research investigating GLI-dependent pathways
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