Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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6,316 – 6,330 of 178,220 results

6,316

Medchemexpress LLC ZSET1446 | 887603-94-3 | 98.01% | 236.27 | 1 MG

ZSET1446 | 887603-94-3 | 98.01% | 236.27 | 1 MG

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6,317

Cayman Chemical 8iso Prostaglandin E2d4

An internal standard for the quantification of 8-iso PGE2 by GC- or LC-MS

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6,318

Cayman Chemical AG879 Inhibitors

A tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM)

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6,319

Medchemexpress LLC JGB1741 | 1256375-38-8 | 99.4% | 440.56 | 10 MG

JGB1741 is a potent and specific SIRT1 activity inhibitor with an IC50 of approximately 15 μM, demonstrating weaker inhibition against SIRT2 and SIRT3 with IC50 values greater than 100 μM. This compound increases acetylated p53 levels, leading to p53-mediated apoptosis through the modulation of Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage. It shows potential for breast cancer research, inhibiting MDA-MB 231 cell proliferation more potently than K562 and HepG2 cells. JGB1741 induces apoptosis and cell cycle arrest at the G1 phase in MDA-MB 231 cells, causing a dose-dependent increase in global acetylation of H3K9, p53 expression, and acetylated p53K382 levels in these cells.

Potent and specific SIRT1 activity inhibitor.
Increases acetylated p53 levels.
Induces apoptosis and cell cycle arrest.
Causes a dose-dependent increase in global acetylation.
Potential for breast cancer research.

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6,320

Medchemexpress LLC 5-(hydroxymethyl)furfural | 67-47-0 | MFCD00003234 | 126.11 g/mol | C6H6O3 | 10mg

5-Hydroxymethylfurfural (Standard) is the analytical standard of 5-Hydroxymethylfurfural This product is intended for research and analytical applications 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural) derived from Cornus officinalis inhibits yeast growth and fermentation as stressors

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6,321

Medchemexpress LLC Exatecan intermediate 12 | 110351-93-4 | C15H17NO6 | 5 G

Exatecan intermediate 12 is a chemical substance used in laboratory research and for the manufacture of other substances. This solid compound has a molecular weight of 307.30 and is classified with acute oral toxicity, skin and serious eye irritation, and may cause respiratory irritation. Proper handling and storage are crucial for safety and stability.

Harmful if swallowed
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
Stable under recommended storage conditions
Recommended storage: -20°C for 3 years (powder), 4°C for 2 years (powder)
Avoid inhalation, contact with eyes and skin
Use in areas with appropriate exhaust ventilation

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6,322

Medchemexpress LLC Epi-inositol | 488-58-4 | MFCD00272608 | >=98.0% | 180.16 g/mol | C6H12O6 | 25 MG

Epi-inositol (CAS 488-58-4) is an inositol isomer supplied as an analytical standard for research and analytical applications. It is offered in small pack sizes for laboratory use and is commonly used as a reference compound in biochemical and analytical assays.

Analytical standard for research and analytical applications.
High purity suitable for HPLC (≥98.0%).
Available in small laboratory pack sizes (for example, 5-100 mg).
Suitable as a reference standard in chromatographic and spectroscopic analyses.
Provided as a solid for routine handling and storage.

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6,323

Medchemexpress LLC Padsevonil | 1294000-61-5 | 99.7% | 432.80 | 10 MG

Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. It binds to synaptic vesicular protein 2 (SV2) with high affinity and is also a positive allosteric modulator and partial agonist of GABAAR, showing high potency against α1 and α5 receptors.

Regulates GABAAR activity through allosteric sites on the receptor in CHO cells.
Enhances natural GABAAR activity in primary rat neurons.
Has protective effects on mouse models of acute epilepsy.
Shows a protective effect in a rodent model of chronic epilepsy.
Significantly decreased hippocampal paroxysmal discharges dose-dependently in kainate treated male mice.
Produced dose-related suppression in the cumulative duration of spontaneous spike and wave discharges in platinum electrodes treated male Wistar rats.

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6,324

eMolecules 1121586-37-5 | 4-Bromo-2,6-dichloropyridin-3-amine | Combi-Blocks | MFCD12546348 | 241.900 | C5H3BrCl2N2 | 97.000 | Nc1c(Br)cc(Cl)nc1Cl | 1g | 401043174

4-Bromo-2,6-dichloropyridin-3-amine | Combi-Blocks | 1121586-37-5 | MFCD12546348 | 241.900 | C5H3BrCl2N2 | 97.000 | Nc1c(Br)cc(Cl)nc1Cl | 1g | 401043174

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6,325

Medchemexpress LLC Rhapontigenin | 500-65-2 | 1 ML

Rhapontigenin, a natural analog of resveratrol, exhibits anticancer, antioxidant, antifungal, and antibacterial activities. It acts as a mechanism-based, potent, and selective cytochrome P450 1A1 inactivator with an IC50 of 400 nM, demonstrating high selectivity over P450 1A2 and P450 1B1.

Anticancer, antioxidant, antifungal, and antibacterial properties
Potent, selective cytochrome P450 1A1 inactivator (IC50 = 400 nM)
400-fold selectivity for P450 1A1 over P450 1A2, 23-fold over P450 1B1
Molecular weight: 258.27; Formula: C15H14O4; Appearance: Solid, light yellow to yellow; Purity: 99.66%
Source: Plants (Leguminosae, Trigonella foenum-graecum Linn.)
Inhibits ADP- and collagen-induced platelet aggregation
Demonstrates in vivo anti-thrombosis activity

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6,326

Medchemexpress LLC Leucine-rich repeat-containing protein 15, human recombinant (Fc tag) | >95.0% | 100 UG

Recombinant human LRRC15 extracellular domain fused to a C-terminal human Fc tag, expressed in HEK293 cells and supplied as a purified protein for biochemical and cell-based assays. The construct corresponds to residues Y22-G538 and is provided with >95% purity; store frozen and aliquot to avoid freeze-thaw.

Fc-tagged extracellular domain for detection and capture assays.
Expressed in HEK293 cells for mammalian glycosylation.
High purity (>95.0%) as determined by reducing SDS-PAGE.
Construct corresponds to residues Y22-G538 (extracellular domain).
Recommended storage: aliquot and freeze at -20°C or -80°C.

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6,327

Medchemexpress LLC Xanthotoxol | 2009-24-7 | 99.5% | 202.16 | 100 MG

Xanthotoxol (8-Hydroxypsoralen) is a fragrant bean substance and a CYP450 inhibitor. It exhibits anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibits CYP3A4 and CYP1A2 with IC50s of 7.43 μM and 27.82 μM, respectively. It can pass through MAPK and NF-κB pathways, inhibiting inflammation.

Fragrant bean substance
CYP450 inhibitor
Anti-inflammatory effects
5-HT antagonistic and protective effects
Inhibits CYP3A4 and CYP1A2
Acts through MAPK and NF-κB pathways to inhibit inflammation

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6,328

eMolecules 1185-53-1 | Tri(hydroxymethyl)aminomethane hydrochloride | AA Blocks LLC | MFCD00012590 | 157.590 | C4H12ClNO3 | 0.000 | Cl.NC(CO)(CO)CO | 25g | 410203698

Tri(hydroxymethyl)aminomethane hydrochloride | AA Blocks LLC | 1185-53-1 | MFCD00012590 | 157.590 | C4H12ClNO3 | 0.000 | Cl.NC(CO)(CO)CO | 25g | 410203698

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6,329

Alkali Scientific Methotrexate, 100 Milligrams

Methotrexate, 100mg, is a laboratory-grade reagent used in research applications to study its effects on cancer, autoimmune diseases, and cellular processes. It is a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, thereby blocking DNA and RNA synthesis, which leads to cell death. Methotrexate is frequently used in cell culture studies, drug testing, and cancer research. The 100mg quantity is ideal for smaller-scale research, providing sufficient material for experiments investigating its cytotoxic effects, as well as its role in targeting rapidly dividing cells in tumor tissues.

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6,330

Medchemexpress LLC Fludarabine | 21679-14-1 | 99.7% | C10H12FN5O4 | 25 MG

Fludarabine is a DNA synthesis inhibitor and a fluorinated purine analogue, exhibiting antineoplastic activity in lymphoproliferative malignancies. It inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.

Acts as a DNA synthesis inhibitor
Functions as a fluorinated purine analogue
Exhibits antineoplastic activity in lymphoproliferative malignancies
Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription
Induces a decrease in p27kip1 expression in vitro
Decreases incidence of graft-versus-host disease in animal models

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Pyridines and derivatives

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Medchemexpress LLC ZSET1446 | 887603-94-3 | 98.01% | 236.27 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical 8iso Prostaglandin E2d4 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical AG879 Inhibitors Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC JGB1741 | 1256375-38-8 | 99.4% | 440.56 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5-(hydroxymethyl)furfural | 67-47-0 | MFCD00003234 | 126.11 g/mol | C6H6O3 | 10mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Exatecan intermediate 12 | 110351-93-4 | C15H17NO6 | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Epi-inositol | 488-58-4 | MFCD00272608 | >=98.0% | 180.16 g/mol | C6H12O6 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Padsevonil | 1294000-61-5 | 99.7% | 432.80 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Rhapontigenin | 500-65-2 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Leucine-rich repeat-containing protein 15, human recombinant (Fc tag) | >95.0% | 100 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Xanthotoxol | 2009-24-7 | 99.5% | 202.16 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Alkali Scientific Methotrexate, 100 Milligrams Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Fludarabine | 21679-14-1 | 99.7% | C10H12FN5O4 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More