Pyridines and derivatives
2-Bromo-4,6-dimethylpyridine 98.0+%, TCI America™
CAS: 4926-26-5 Molecular Formula: C7H8BrN Molecular Weight (g/mol): 186.05 MDL Number: MFCD00082591 InChI Key: IRTOCXBLUOPRFT-UHFFFAOYSA-N Synonym: 2-Bromo-4,6-lutidine PubChem CID: 14975195 IUPAC Name: 2-bromo-4,6-dimethylpyridine SMILES: CC1=CC(C)=NC(Br)=C1
2-Chloro-6-methylpyridine, 98%
CAS: 18368-63-3 Molecular Formula: C6H6ClN Molecular Weight (g/mol): 127.57 MDL Number: MFCD00006245 InChI Key: GXZDYRYYNXYPMQ-UHFFFAOYSA-N Synonym: 6-chloro-2-picoline,6-chloro-2-methylpyridine,pyridine, 2-chloro-6-methyl,2-chloro-6-picoline,2-picoline, 6-chloro,unii-39mx1lq68l,2-chloro-6-methyl pyridine,2-chloro-6-methyl-pyridine,2-chloro-6-methy pyridine PubChem CID: 87601 IUPAC Name: 2-chloro-6-methylpyridine SMILES: CC1=CC=CC(Cl)=N1
2-Methyl-5-nitropyridine 96.0+%, TCI America™
CAS: 21203-68-9 Molecular Formula: C6H6N2O2 Molecular Weight (g/mol): 138.126 MDL Number: MFCD04114179 InChI Key: USZINSZJSVMICC-UHFFFAOYSA-N Synonym: 5-nitro-2-picoline,pyridine, 2-methyl-5-nitro,5-nitro-2-methylpyridine,2-methyl-5-nitro-pyridine,pubchem6699,acmc-1cewl,2-methyl-5-nitro pyridine,ksc494i9p,abbypharma ap-15-5036 PubChem CID: 2794552 IUPAC Name: 2-methyl-5-nitropyridine SMILES: CC1=NC=C(C=C1)[N+](=O)[O-]
2-Amino-5-bromo-3-nitropyridine 97.0+%, TCI America™
CAS: 6945-68-2 Molecular Formula: C5H4BrN3O2 Molecular Weight (g/mol): 218.01 MDL Number: MFCD00047441 InChI Key: QOOCOFOGYRQPPN-UHFFFAOYSA-N Synonym: 2-amino-5-bromo-3-nitropyridine,5-bromo-3-nitro-pyridin-2-ylamine,5-bromo-3-nitro-2-pyridylamine,2-amino-3-nitro-5-bromopyridine,2-pyridinamine, 5-bromo-3-nitro,5-bromo-3-nitro-2-pyridinamine,pubchem1105,maybridge1_001193,acmc-1b8cy,ksc496e6b PubChem CID: 138878 IUPAC Name: 5-bromo-3-nitropyridin-2-amine SMILES: NC1=NC=C(Br)C=C1[N+]([O-])=O
2-Hydroxy-5-methylpyridine 98.0+%, TCI America™
CAS: 1003-68-5 Molecular Formula: C6H7NO Molecular Weight (g/mol): 109.128 InChI Key: SOHMZGMHXUQHGE-UHFFFAOYSA-N Synonym: 2-hydroxy-5-methylpyridine,5-methylpyridin-2-ol,2-hydroxy-5-picoline,5-methyl-2-pyridinol,5-methylpyridin-2 1h-one,5-methyl-2-pyridone,5-methyl-2 1h-pyridinone,2 1h-pyridinone, 5-methyl,2-pyridinol, 5-methyl,6-hydroxy-3-picoline PubChem CID: 70482 IUPAC Name: 5-methyl-1H-pyridin-2-one SMILES: CC1=CNC(=O)C=C1
Apexbio Technology LLC Kobe0065 436133-68-5 100mg
Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms
Apexbio Technology LLC Kobe0065 436133-68-5 10mg
Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms
Medchemexpress LLC Kobe2601 | 316151-68-5 | 99.7% | 5 MG
Kobe2601 is a small-molecule research probe that acts as an analogue of Kobe family compounds with reported activity against Ras and Raf. It is intended for in vitro research and is annotated to affect GPCR/G protein and MAPK/ERK signaling pathways.
- Small-molecule Ras and Raf probe for biochemical studies.
- Annotated to modulate GPCR/G protein and MAPK/ERK signaling.
- Available as a 5 mg vial for laboratory use.
- Molecular weight 351.31; formula C13H10FN5O4S.
- Soluble in DMSO for stock solution preparation.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Norethynodrel | 68-23-5 | 90.53% | 1 MG
Norethynodrel is a 19-nortestosterone derivative used as a progestagen for researching inhibition of ovulation. It is also a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Derivative of 19-nortestosterone.
- Used as a progestagen.
- Can be used for researching inhibition of ovulation.
- Click chemistry reagent.
- Contains an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Medchemexpress LLC Cinobufotalin | 1108-68-5 | 458.54 | 1 MG
Cinobufotalin is a cardiotonic steroid or bufadienolide extracted from the skin secretions of giant toads. It has been used as a cardiotonic, diuretic, and hemostatic agent, and is also a potential anti-lung cancer agent. It is for research use only.
- Cardiotonic steroid
- Bufadienolide
- Extracted from giant toad skin secretions
- Functions as a cardiotonic, diuretic, and hemostatic agent
- Potential anti-lung cancer properties
- For research use only
- Provided as 1 mg
Medchemexpress LLC Monuron | 150-68-5 | 100.0% | 50 MG
Monuron is a phenylurea herbicide that functions by inhibiting photosynthesis.
- It is a phenylurea herbicide.
- It inhibits photosynthesis.
- Available as a white to light yellow solid.
- High purity of 99.96%.
- Soluble in DMSO.
Medchemexpress LLC Amifostine trihydrate | 112901-68-5 | 99.95% | 5 MG
Amifostine trihydrate is a broad-spectrum cytoprotective agent and radioprotector. It selectively protects normal tissues from damage caused by radiation and chemotherapy. This agent acts as a potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer, protecting cells by scavenging oxygen-derived free radicals, reducing renal toxicity, and exhibiting antiangiogenic action.
- Selectively protects normal tissues from radiation and chemotherapy damage.
- Potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer.
- Protects cells by scavenging oxygen-derived free radicals.
- Reduces renal toxicity.
- Exhibits antiangiogenic action.
- Reduces tert-butyl hydroperoxide (TBHP)-induced cell damage in vitro.
- Attenuates cardiomyocyte apoptosis and reduces reactive oxygen species (ROS) in vivo.
Medchemexpress LLC DKFZ-748 | 2490709-68-5 | C18H23N3O3 | 5 MG
DKFZ-748 is a selective HDAC10 inhibitor that demonstrates anti-tumor activity. This compound shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model. It also induces HDAC acetylation of BE(2)-C cells and leads to significant accumulation of N8 acetyl- and N1,8-diacetylspermidine.
- Selective HDAC10 inhibitor
- Exhibits anti-tumor activity
- Induces dose-dependent growth inhibition in HeLa cells
- Promotes HDAC acetylation of BE(2)-C cells
- Leads to significant accumulation of N8 acetyl- and N1,8-diacetylspermidine
Medchemexpress LLC Kobe2601 | 316151-68-5 | 99.7% | 100 MG
Kobe2601 is a small-molecule research compound (CAS 316151-68-5) described as an analogue of Kobe0065 and used to probe the mechanism of action of the Kobe family of compounds. It is supplied in milligram quantities for in vitro research use and intended for qualified laboratory personnel.
- Small-molecule compound for mechanism-of-action studies.
- Available in multiple milligram pack sizes for laboratory use.
- Provided with analytical data where available.
- Intended for research use only, not for human or clinical use.
- Store according to supplier recommendations under controlled conditions.
Medchemexpress LLC Cinobufotalin | 1108-68-5 | 458.54 | 1 ML
Cinobufotalin is a cardiotonic steroid or bufadienolide extracted from the skin secretions of giant toads. It has been used as a cardiotonic, diuretic, and hemostatic agent, and is also considered a potential anti-lung cancer agent.
- Cardiotonic steroids or bufadienolides
- Extracted from the skin secretions of giant toads
- Potential anti-lung cancer agent
- High purity
- For research use only