Pyridines and derivatives
2,6-Dimethyl-3-nitropyridine 98.0+%, TCI America™
CAS: 15513-52-7 Molecular Formula: C7H8N2O2 Molecular Weight (g/mol): 152.153 MDL Number: MFCD00023503 InChI Key: AETHUDGJSSKZKT-UHFFFAOYSA-N PubChem CID: 84958 IUPAC Name: 2,6-dimethyl-3-nitropyridine SMILES: CC1=NC(=C(C=C1)[N+](=O)[O-])C
2-Amino-3,5-dichloro-6-methylpyridine 97.0+%, TCI America™
CAS: 22137-52-6 Molecular Formula: C6H6Cl2N2 Molecular Weight (g/mol): 177.028 MDL Number: MFCD00129029 InChI Key: NQYNSMVHXHIGHZ-UHFFFAOYSA-N Synonym: 6-Amino-3,5-dichloro-2-picoline PubChem CID: 1415863 IUPAC Name: 3,5-dichloro-6-methylpyridin-2-amine SMILES: CC1=NC(=C(C=C1Cl)Cl)N
Ethyl 2,4-Dihydroxy-6-methylnicotinate 98.0+%, TCI America™
CAS: 70254-52-3 Molecular Formula: C9H11NO4 Molecular Weight (g/mol): 197.19 MDL Number: MFCD02929397 InChI Key: CMCZAWPDHHYFPU-UHFFFAOYSA-N PubChem CID: 54676534 IUPAC Name: ethyl 4-hydroxy-6-methyl-2-oxo-1H-pyridine-3-carboxylate SMILES: CCOC(=O)C1=C(C=C(NC1=O)C)O
Apexbio Technology LLC Nifuroxazide 965-52-6 500mg
Nifuroxazide (CAS 965-52-6) is a small-molecule inhibitor targeting signal transducer and activator of transcription (STAT) signaling pathways It is designed to inhibit activation of STAT1 STAT3 and STAT5 thereby suppressing cytokine-mediated transcriptional activities Nifuroxazide exerts its biological activity primarily through inhibition of STAT phosphorylation and activation In cell-based assays Nifuroxazide demonstrates inhibitory activity with an IC50 value of approximately 3 M against STAT3 phosphorylation and activation in IL-6-stimulated U3A cells Based on these pharmacological properties Nifuroxazide holds research potential in studies of STAT-driven signaling processes and in exploring therapeutic strategies for diseases associated with aberrant cytokine signaling and STAT pathway activation
Apexbio Technology LLC AZD6244 (Selumetinib) 606143-52-6 500mg
AZD6244 (Selumetinib CAS 606143-52-6) is a small-molecule inhibitor selectively targeting MEK1/2 components of the MAP kinase signaling cascade It inhibits MEK1 via a non-ATP-competitive mechanism with an IC50 of 14 1 nM leading to decreased phosphorylation of downstream targets ERK1/2 (IC50 10 3 nM cellular assays) AZD6244 exhibits minimal off-target activity against related kinases including MKK6 EGFR ErbB2 and B-Raf In tumor cell lines harboring activated Ras or B-Raf mutations AZD6244 reduces cell proliferation and inhibits growth in xenograft models Thus AZD6244 is useful for investigating MAP kinase pathway-driven malignancies
Medchemexpress LLC SZM679 | 3027645-52-6 | C27H18F5N3O5S | 50 MG
SZM679 | 3027645-52-6 | C27H18F5N3O5S | 50 MG
Medchemexpress LLC SZM679 | 3027645-52-6 | C27H18F5N3O5S | 100 MG
SZM679 is a potent, orally active, and selective RIPK1 inhibitor. It reverses tumor necrosis factor-induced systemic inflammatory response and decreases Tau hyperphosphorylation, neuroinflammation, and RIPK1 phosphorylation levels. This compound is valuable for research, particularly in the study of Alzheimer's disease.
- Potent and selective RIPK1 inhibitor (Kd 8.6 nM)
- Reverses TNF-induced systemic inflammatory response
- Decreases Tau hyperphosphorylation and neuroinflammation
- Reduces RIPK1 phosphorylation levels
- Protects against necroptosis
- Inhibits expression of RIPK1 and blocks necrosome formation
- Improves cognitive function and anxiety in AD models
- Rescues brain structure damage
Medchemexpress LLC Nifuroxazide | 965-52-6 | 99.9% | 1 ML
Nifuroxazide is an effective inhibitor of STAT3, also exerting potent anti-tumor and anti-metastasis activity. It is an orally active nitrofuran antibiotic.
- Target is STAT3.
- Exhibits cytotoxicity against various human and NIH3T3 cell lines.
- Induces a significant dose-dependent decrease in STAT3 tyrosine phosphorylation in U266 cells.
- Causes dose-dependent loss of cell viability in U266 and INA6 cells.
- Inhibits tumor growth and weight in a dose-dependent manner.
- Inhibits proliferation of Ki-67-positive cells and induces apoptosis.
- Inhibits expression of MMP-2, MMP-9, and p-Stat3 in tumor tissues.
- Inhibits infiltration of MDSCs into the lung, suppressing distant colonization of tumor cells.
- Appearance is solid.
- Color is light yellow to yellow.
Medchemexpress LLC SZM679 | 3027645-52-6 | C27H18F5N3O5S | 5 MG
SZM679 is a potent, orally active, and selective RIPK1 inhibitor with Kd values of 8.6 nM for RIPK1 and >5000 nM for RIPK3. It reverses tumor necrosis factor-induced systemic inflammatory response and decreases Tau hyperphosphorylation, neuroinflammation, and RIPK1 phosphorylation in the hippocampus and cortex. SZM679 can be used in research for Alzheimer's disease (AD). For research use only.
- Exhibits anti-necrosis activity by inhibiting the RIPK1 pathway with an EC50 value of 2 nM.
- Protects against TNF-α, cycloheximide, and z-VAD-fmk (TCZ)-induced necroptosis.
- Selectively inhibits RIPK1 expression and blocks necrosome formation.
- Improves cognitive function and rescues brain structure damage in AD mice.
- Decreases AD biomarkers and inflammatory cytokine levels in brain tissues.
Medchemexpress LLC SZM679 | 3027645-52-6 | C27H18F5N3O5S | 1 ML
SZM679 is a potent, orally active, and selective RIPK1 inhibitor with Kd values of 8.6 nM for RIPK1. It reverses tumor necrosis factor-induced systemic inflammatory response, decreases Tau hyperphosphorylation, neuroinflammation, and RIPK1 phosphorylation levels. This compound is used in research for Alzheimer's disease (AD) due to its ability to improve cognitive function and rescue brain structural damage.
- Potent, orally active, and selective RIPK1 inhibitor.
- Reverses tumor necrosis factor-induced systemic inflammatory response.
- Decreases Tau hyperphosphorylation, neuroinflammation, and RIPK1 phosphorylation levels.
- Used in research for Alzheimer's disease.
- Inhibits the RIPK1 pathway.
- Protects against necroptosis.
- Improves cognitive function in AD models.
- Rescues brain structure damage and decreases AD biomarkers.
Medchemexpress LLC Nifuroxazide | 965-52-6 | 99.9% | 1 G
Nifuroxazide is an effective inhibitor of STAT3, exhibiting potent anti-tumor and anti-metastasis activity. It is an orally active nitrofuran antibiotic.
- Effective inhibitor of STAT3
- Exhibits potent anti-tumor and anti-metastasis activity
- Orally active nitrofuran antibiotic
Medchemexpress LLC SZM679 | 3027645-52-6 | C27H18F5N3O5S | 25 MG
SZM679 | 3027645-52-6 | C27H18F5N3O5S | 25 MG
Medchemexpress LLC Unc9995 | 1354030-52-6 | 99.9% | 10 MG
UNC9995 is a β-arrestin2-biased agonist of the dopamine D2 receptor (Drd2), supplied as a white to off-white solid for laboratory research use only. It inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction and has been used in preclinical studies to modulate inflammation and depressive-like behaviors.
- β-arrestin2-biased agonist of dopamine D2 receptor
- CAS 1354030-52-6; molecular formula C20H21Cl2N3OS
- Purity 99.9%
- Molecular weight 422.37 g·mol⁻1
- Soluble in DMSO (50 mg/mL with warming and sonication)
- Store powder at -20°C; store solutions at -80°C for long term
- For research use only; not for human or clinical use
Medchemexpress LLC Nifuroxazide | 965-52-6 | 99.9% | 5 G
Nifuroxazide is an effective inhibitor of STAT3, and also exerts potent anti-tumor and anti-metastasis activity. It is an orally active nitrofuran antibiotic.
- Effective inhibitor of STAT3
- Potent anti-tumor activity
- Potent anti-metastasis activity
- Orally active nitrofuran antibiotic
Medchemexpress LLC Nifuroxazide | 965-52-6 | 99.9% | 500 MG
Nifuroxazide is an orally active nitrofuran antibiotic. It is an effective inhibitor of STAT3 and also demonstrates potent anti-tumor and anti-metastasis activity. It is for research use only and not sold to patients.
- Effective inhibitor of STAT3
- Potent anti-tumor and anti-metastasis activity
- Orally active nitrofuran antibiotic
- Used in various cellular assays
- Available in solid and solution forms