Pyridines and derivatives
Apexbio Technology LLC CCT137690 1095382-05-0 50mg
CCT137690 (CAS 1095382-05-0) is an orally bioavailable small molecule inhibitor of aurora kinases targeting aurora A B and C with reported IC50 values between 15 and 25 nM Aurora kinases are serine/threonine kinases involved in the regulation of mitosis and are implicated in the progression of various cancers CCT137690 demonstrates potent inhibition of aurora kinase-mediated phosphorylation of histone H3 and suppresses proliferation in several cancer cell lines including ovarian and colorectal models with submicromolar IC50 values In vivo it slows tumor growth in xenograft models and sensitizes cells to radiotherapy CCT137690 is valuable for investigating aurora kinase function and chemoradiotherapeutic strategies in oncology research
Apexbio Technology LLC CCT137690 1095382-05-0 10mg
CCT137690 (CAS 1095382-05-0) is an orally bioavailable small molecule inhibitor of aurora kinases targeting aurora A B and C with reported IC50 values between 15 and 25 nM Aurora kinases are serine/threonine kinases involved in the regulation of mitosis and are implicated in the progression of various cancers CCT137690 demonstrates potent inhibition of aurora kinase-mediated phosphorylation of histone H3 and suppresses proliferation in several cancer cell lines including ovarian and colorectal models with submicromolar IC50 values In vivo it slows tumor growth in xenograft models and sensitizes cells to radiotherapy CCT137690 is valuable for investigating aurora kinase function and chemoradiotherapeutic strategies in oncology research
Apexbio Technology LLC Dihydrodaidzein 17238-05-0 25mg
Dihydrodaidzein (CAS 17238-05-0) is a biologically active metabolite of the soy isoflavone daidzein generated through gut microbial metabolism Acting as an estrogen receptor agonist dihydrodaidzein activates estrogen receptor-mediated processes and has been shown to promote the growth of breast cancer cells in vitro at micromolar concentrations It inhibits proliferation and induces apoptosis in benign prostatic epithelial cells as well as suppresses growth of prostate cancer cell lines In murine models oral administration reduced vascular smooth muscle cell migration and proliferation selectively blocking neointimal hyperplasia Dihydrodaidzein is a valuable tool in studies of phytoestrogen activity hormone-dependent cancers and vascular remodeling
Apexbio Technology LLC Dihydrodaidzein 17238-05-0 50mg
Dihydrodaidzein (CAS 17238-05-0) is a biologically active metabolite of the soy isoflavone daidzein generated through gut microbial metabolism Acting as an estrogen receptor agonist dihydrodaidzein activates estrogen receptor-mediated processes and has been shown to promote the growth of breast cancer cells in vitro at micromolar concentrations It inhibits proliferation and induces apoptosis in benign prostatic epithelial cells as well as suppresses growth of prostate cancer cell lines In murine models oral administration reduced vascular smooth muscle cell migration and proliferation selectively blocking neointimal hyperplasia Dihydrodaidzein is a valuable tool in studies of phytoestrogen activity hormone-dependent cancers and vascular remodeling
Apexbio Technology LLC Dihydrodaidzein 17238-05-0 10mg
Dihydrodaidzein (CAS 17238-05-0) is a biologically active metabolite of the soy isoflavone daidzein generated through gut microbial metabolism Acting as an estrogen receptor agonist dihydrodaidzein activates estrogen receptor-mediated processes and has been shown to promote the growth of breast cancer cells in vitro at micromolar concentrations It inhibits proliferation and induces apoptosis in benign prostatic epithelial cells as well as suppresses growth of prostate cancer cell lines In murine models oral administration reduced vascular smooth muscle cell migration and proliferation selectively blocking neointimal hyperplasia Dihydrodaidzein is a valuable tool in studies of phytoestrogen activity hormone-dependent cancers and vascular remodeling
Apexbio Technology LLC VKGILS-NH2 942413-05-0 5mg
VKGILS-NH2 (CAS 942413-05-0) is a synthetic peptide that serves as the reverse-sequence control for the protease-activated receptor 2 (PAR2) agonist SLIGKV-NH2 PAR2 a G protein-coupled receptor expressed in airway and gastrointestinal tissues is implicated in inflammatory responses and vascular regulation In vitro studies have used VKGILS-NH2 to differentiate nonspecific effects from PAR2 activation showing that in contrast to the agonist VKGILS-NH2 does not enhance mucin secretion in bronchial epithelial cells In vivo VKGILS-NH2 functions as a negative control lacking the vasodilatory or contractile responses observed with PAR2 agonists supporting its use in mechanistic studies of PAR2 signaling
Medchemexpress LLC Thozalinone 50mg | 655-05-0 | 50MG
Thozalinone is an orally active antidepressant agent Thozalinone induces the release of Norepinephrine (HY-13715) and dopamine[1 [2
Medchemexpress LLC Thozalinone 5mg | 655-05-0 | 5MG
Thozalinone is an orally active antidepressant agent Thozalinone induces the release of Norepinephrine (HY-13715) and dopamine[1 [2
Medchemexpress LLC YM511 5mg | 148869-05-0 | 5MG
YM511 is a highly specific non-steroidal aromatase inhibitor YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0 4 and 0 12 nM respectively) YM511 slightly inhibits production of other steroid hormones YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones[1
Medchemexpress LLC Hexythiazox | 78587-05-0 | 99.55% | 1 ML
Hexythiazox is a selective acaricide that exhibits ovicidal, larvicidal, and nymphicidal activities. It is widely used for controlling mites on cotton, fruits, and vegetables. It is considered harmless to mammals and does not affect beneficial insects or predators of mites.
- Selective acaricide
- Ovicidal, larvicidal, and nymphicidal activities
- Widely used for chemical control of mites on cotton, fruits, and vegetables
- Harmless to mammals
- No effect on beneficial insects and predators of mites
Medchemexpress LLC Rehmannioside A | 81720-05-0 | 524.47 | 5 MG
Rehmannioside A | 81720-05-0 | 524.47 | 5 MG
Medchemexpress LLC Sevabertinib | 2521285-05-0 | 99.9% | 484.93 | 25 MG
Sevabertinib (BAY 2927088) is an orally active and reversible dual EGFR-HER2 inhibitor with IC50 values of <0.5 nM for wild-type HER2, HER2 A775insYVMA, wild-type EGFR, and EGFR D770_N771insSVD. It demonstrates anticancer activity against lung cancer.
- Orally active and reversible dual EGFR-HER2 inhibitor.
- Potent inhibition of multiple HER2 and EGFR forms (IC50 <0.5 nM).
- Shows anticancer activity against lung cancer.
- Inhibits proliferation of isogenic Ba/F3 cells with HER2 exon 20 insertions or resistance mutations.
- Potently inhibits proliferation of NCI-H1781 and NCI-H2170 lung cancer cell lines.
- Demonstrates tumor growth inhibition in PDX mouse models of NSCLC.
- Shows antitumor efficacy in NCI-H1781 xenograft mouse model.
Medchemexpress LLC Lipid 14 | 2430034-05-0 | C56H110N2O6 | 1 ML
Lipid 14 is an ionizable amino lipid that facilitates the delivery of mRNA into target cells. It significantly enhances the in vivo expression efficiency and immunogenicity of mRNA. This lipid can be utilized for the synthesis of lipid nanoparticles (LNPs) and has applications in studies related to SARS-CoV-2 and Yersinia pestis.
- Delivers mRNA into target cells.
- Significantly enhances in vivo expression efficiency of mRNA.
- Significantly enhances the immunogenicity of mRNA.
- Can be used to synthesize lipid nanoparticles (LNPs).
- Applicable for studies of SARS-CoV-2 and Yersinia pestis.
Medchemexpress LLC ML230 | 1776055-05-0 | 99.65% | 439.47 | 100 MG
ML230 is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2.
- Demonstrates 36-fold selectivity for ABCG2 over ABCB1.
- EC50 values of 0.13 μM for ABCG2 and 4.65 μM for ABCB1.
Medchemexpress LLC Ml230 | 1776055-05-0 | 99.7% | 439.47 | 1 ML
ML230 is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2. It is 36-fold selective for ABCG2 over ABCB1 with EC50 values of 0.13 μM and 4.65 μM, respectively. It is intended for research use only.
- Selective inhibitor of ATP-binding cassette transporter ABCG2.
- 36-fold selective for ABCG2 over ABCB1.
- Available in solid and solution forms.
- Multiple quantities available.
- Detailed solubility and storage information provided.
- Information for *in vitro* and *in vivo* use.