Pyridines and derivatives
2-Chloro-5-nitropyridine 99.0+%, TCI America™
CAS: 4548-45-2 Molecular Formula: C5H3ClN2O2 Molecular Weight (g/mol): 158.54 MDL Number: MFCD00006240 InChI Key: BAZVFQBTJPBRTJ-UHFFFAOYSA-N Synonym: pyridine, 2-chloro-5-nitro,2-chloro-5-nitro-pyridine,3-nitro-6-chloropyridine,chloro 2--5-nitropyridine,2-chloro-5-nitro pyridine,zlchem 162,pubchem1190,chloro-5-nitropyridine,2chloro-5-nitropyridine,2-chloro-5-nitropyridin PubChem CID: 78308 IUPAC Name: 2-chloro-5-nitropyridine SMILES: [O-][N+](=O)C1=CC=C(Cl)N=C1
2-Chloro-3,5-dinitropyridine 98.0+%, TCI America™
CAS: 2578-45-2 Molecular Formula: C5H2ClN3O4 Molecular Weight (g/mol): 203.538 MDL Number: MFCD00006233 InChI Key: QLHVJBXAQWPEDI-UHFFFAOYSA-N Synonym: pyridine, 2-chloro-3,5-dinitro,2-chloro-3,5-dinitro-pyridine,pubchem6103,acmc-209gmh,2-chloro3,5-dinitropyridine,2-chloro-3,5-dinitropyridine PubChem CID: 75738 IUPAC Name: 2-chloro-3,5-dinitropyridine SMILES: C1=C(C=NC(=C1[N+](=O)[O-])Cl)[N+](=O)[O-]
2-Bromo-5-hydroxypyridine 98.0+%, TCI America™
CAS: 55717-45-8 Molecular Formula: C5H6BNO Molecular Weight (g/mol): 106.92 MDL Number: MFCD04114184 InChI Key: ADHMWMAEKRZWPB-UHFFFAOYSA-N Synonym: 2-bromo-5-hydroxypyridine,6-bromo-3-pyridinol,6-bromo-3-hydroxypyridine,3-pyridinol, 6-bromo,5-hydroxy-2-bromopyridine,pubchem5967,zlchem 1240,2-bromopyridine-5-ol,acmc-209lor,3-hydroxy-6-bromopyridine PubChem CID: 2762865 IUPAC Name: 6-boranylpyridin-3-ol SMILES: BC1=CC=C(O)C=N1
6-Hydroxy-2-methyl-3-nitropyridine 98.0+%, TCI America™
CAS: 28489-45-4 Molecular Formula: C6H6N2O3 Molecular Weight (g/mol): 154.125 InChI Key: AJDDHNXZBGZBJN-UHFFFAOYSA-N Synonym: 6-methyl-5-nitropyridin-2-ol,2-hydroxy-6-methyl-5-nitropyridine,6-hydroxy-3-nitro-2-picoline,2-hydroxy-5-nitro-6-picoline,6-hydroxy-2-methyl-3-nitropyridine,6-methyl-5-nitropyridin-2 1h-one,2 1h-pyridinone, 6-methyl-5-nitro,6-methyl-5-nitro-2-pyridinol,6-methyl-5-nitro-pyridin-2-ol,pubchem10387 PubChem CID: 543053 IUPAC Name: 6-methyl-5-nitro-1H-pyridin-2-one SMILES: CC1=C(C=CC(=O)N1)[N+](=O)[O-]
Dipropyl 2,5-Pyridinedicarboxylate 98.0+%, TCI America™
CAS: 136-45-8 Molecular Formula: C13H17NO4 Molecular Weight (g/mol): 251.282 MDL Number: MFCD00055315 InChI Key: IITCWRFYJWUUPC-UHFFFAOYSA-N Synonym: dipropyl 2,5-pyridinedicarboxylate,dipropyl isocinchomeronate,di-propylisocinchomeronate,repper 333,di-n-propyl isocinchomeronate,2,5-pyridinedicarboxylic acid, dipropyl ester,mgk r-326,caswell no. 400,isocinchomeronic acid, dipropyl ester,mgk repellent 326 PubChem CID: 8693 IUPAC Name: dipropyl pyridine-2,5-dicarboxylate SMILES: CCCOC(=O)C1=CN=C(C=C1)C(=O)OCCC
Methyl 5-Methylnicotinate 98.0+%, TCI America™
CAS: 29681-45-6 Molecular Formula: C8H9NO2 Molecular Weight (g/mol): 151.165 MDL Number: MFCD01075739 InChI Key: KQILMMLAGGFMCM-UHFFFAOYSA-N PubChem CID: 256308 IUPAC Name: methyl 5-methylpyridine-3-carboxylate SMILES: CC1=CN=CC(=C1)C(=O)OC
Apexbio Technology LLC Nisin 1414-45-5 10g
Nisin a member of lantibiotic antibiotics is an antibacterial peptide synthesized by Lactococcus lactis utilizing uncommon amino acids such as lanthionine This compound has demonstrated antimicrobial activity through pore formation in bacterial cell membranes In vitro research indicates that nisin could inhibit mammalian sperm motility rapidly at concentrations ranging from approximately 50 g (rat) to 300-400 g (human and non-human primate) displaying dose- and time-dependent inhibition In animal studies intravaginal application before mating terminated sperm motility and prevented fertilization without observable toxicity Current investigations explore nisin as a potential topical contraceptive agent yet clinical trials have not commenced and an explicit IC50 value remains unreported
Apexbio Technology LLC Carmofur 61422-45-5 100mg
Carmofur is a fluorouracil derivative that functions as an anticancer agent by inhibiting thymidylate synthetase thereby interfering with DNA synthesis and cell proliferation As a cytostatic compound it is used primarily in oncology research for in vitro studies investigating tumor growth inhibition pathways Research demonstrates Carmofur s cytotoxic activity in various cancer cell lines with reported IC50 values typically ranging from approximately 5 to 50 M depending on the cell type and culture conditions It is commonly applied in cellular assays including viability assays apoptosis pathway analysis and mechanistic studies of fluorouracil resistance providing insight into targeted pharmacological interventions and chemotherapeutic response mechanisms
Medchemexpress LLC Colestilan | 95522-45-5 | 50 MG
Colestilan is a non-absorbed, non-calcium-based phosphate binder and a non-metallic, anion exchange resin. It is orally active and can be used for hypercholesterolaemia research. This product is for research use only.
- Decreases cholesterol levels by bile acid adsorption
- Binds phosphate in vitro
- Dose-dependently decreases blood phosphate and urinary phosphate excretion in rats
- Improves hyperphosphataemia in rats with renal failure
Apexbio Technology LLC Nisin 1414-45-5 5g
Nisin a member of lantibiotic antibiotics is an antibacterial peptide synthesized by Lactococcus lactis utilizing uncommon amino acids such as lanthionine This compound has demonstrated antimicrobial activity through pore formation in bacterial cell membranes In vitro research indicates that nisin could inhibit mammalian sperm motility rapidly at concentrations ranging from approximately 50 g (rat) to 300-400 g (human and non-human primate) displaying dose- and time-dependent inhibition In animal studies intravaginal application before mating terminated sperm motility and prevented fertilization without observable toxicity Current investigations explore nisin as a potential topical contraceptive agent yet clinical trials have not commenced and an explicit IC50 value remains unreported
Medchemexpress LLC Nisin | 1414-45-5 | 3354.07 | 5 G
Nisin is a bacteriocin produced by Gram-positive bacteria, including Lactococcus and Streptococcus species, and exhibits both antibacterial and anti-inflammatory activities. It is suitable for various research applications.
- Inhibits HNSCC cell ballooning
- Induces free-living amoeba cell cycle arrest
- Reduces uterine inflammation in rats by modulating pro-inflammatory and anti-inflammatory cytokines
Apexbio Technology LLC HU 211 112924-45-5 1mg
HU 211 is a small-molecule antagonist targeting N-methyl-D-aspartate (NMDA) receptors It is designed to inhibit NMDA receptor activity thereby modulating excitatory neurotransmission and associated neurotoxicity HU 211 exerts its biological activity primarily through non-competitive antagonism of NMDA receptors and competitively reduces the binding of [ 3H]MK-801 to neuronal membranes In in vitro studies HU 211 demonstrates dose-dependent inhibition of NMDA-induced neuronal toxicity and suppresses lipopolysaccharide (LPS)-triggered nitric oxide and tumor necrosis factor-alpha (TNF- ) release in macrophage cell lines Based on these pharmacological properties HU 211 holds research potential in studies of neurological injury and inflammation
Medchemexpress LLC Nisin | 1414-45-5 | 3354.07 | 500 MG
Nisin is a bacteriocin produced by specific Gram-positive bacteria, including Lactococcus and Streptococcus species. It exhibits both antibacterial and anti-inflammatory activities.
- Produced by Gram-positive bacteria.
- Exhibits antibacterial activity.
- Shows anti-inflammatory activity.
- Inhibits HNSCC cell ballooning in vitro.
- Induces free-living amoeba acanthamoeba cell cycle arrest in vitro.
- Reduces uterine inflammation in rats by regulating pro-inflammatory and anti-inflammatory cytokines in vivo.
Medchemexpress LLC 8-Shogaol | 36700-45-5 | 1 ML
8-Shogaol, a stimulating compound from ginger, exhibits antiplatelet, anti-cancer, and anti-inflammatory activities. It inhibits COX-2, leading to a decline in human leukemia cells, and selectively targets TAK1, suppressing IKK, Akt, and MAPK signaling pathways. It also reverses synovitis in rheumatoid arthritis (RA) and demonstrates cytotoxic effects on HL-60 cell growth and inhibits inflammation in RA patient-derived FLS.
- Exhibits antiplatelet, anti-cancer, and anti-inflammatory activities.
- Inhibits COX-2 (IC50=17.5 μM) and selectively targets TAK1 (IC50=5 μM).
- Suppresses IKK, Akt, and MAPK signaling pathways.
- Reverses synovitis in rheumatoid arthritis.
- Cytotoxic to HL-60 cell growth (10-50 μM).
- Inhibits TNF-α, IL-1β, and IL-17-mediated inflammation.
- Reduces paw thickness and improves walking performance in rat models of adjuvant-induced arthritis.
Medchemexpress LLC Carmofur | 61422-45-5 | 99.95% | 100 MG
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. It also acts as a protease inhibitor for SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH), and N-acylethanolamine acid amidase (NAAA). This compound exhibits anti-cancer, anti-inflammatory, and anti-virus activities, making it suitable for studying COVID-19 and acute lung injury (ALI).
- Inhibits acid ceramidase (IC50: 29 nM)
- Acts as a protease inhibitor for SARS-CoV-2 Mpro
- Inhibits fatty acid amide hydrolase (FAAH)
- Inhibits N-acylethanolamine acid amidase (NAAA)
- Exhibits anti-cancer activity
- Exhibits anti-inflammatory activity
- Exhibits anti-virus activity
- Used for studying COVID-19 and acute lung injury (ALI)