Pyrimidines And Derivatives
Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.
Quantity
- (4)
- (2)
- (372)
- (11)
- (1)
- (1)
- (32)
- (8)
- (70)
- (1)
- (25)
- (2)
- (2)
- (14)
- (190)
- (4)
- (2)
- (7)
- (20)
- (1)
- (69)
- (1)
- (279)
- (11)
- (4)
- (11)
- (32)
- (2)
- (7)
- (1)
Molecular Weight (g/mol)
- (1)
- (1)
- (1)
- (1)
- (1)
- (21)
- (1)
- (23)
- (7)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (12)
- (3)
- (4)
- (4)
- (4)
- (1)
- (4)
- (7)
- (4)
- (13)
- (1)
- (13)
- (2)
- (1)
- (3)
- (2)
- (1)
- (1)
- (4)
- (7)
- (10)
- (3)
- (17)
- (2)
- (1)
- (2)
- (2)
- (4)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (1)
- (1)
- (3)
- (5)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (4)
- (1)
- (8)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (4)
- (2)
- (1)
- (3)
- (1)
- (4)
- (1)
- (3)
- (1)
- (2)
- (4)
- (2)
- (1)
- (9)
- (1)
- (1)
- (1)
- (2)
- (6)
- (2)
- (1)
- (17)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (7)
- (1)
- (1)
- (2)
- (4)
- (4)
- (3)
- (1)
- (5)
- (3)
- (1)
- (2)
- (1)
- (1)
- (3)
- (3)
- (4)
- (2)
- (1)
- (8)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (4)
- (1)
- (2)
- (1)
- (5)
- (1)
- (6)
- (2)
- (1)
- (3)
- (9)
- (2)
- (2)
- (2)
- (3)
- (2)
- (2)
- (4)
- (2)
- (1)
- (5)
- (11)
- (6)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (7)
- (2)
- (2)
- (1)
- (1)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (4)
- (1)
- (1)
- (4)
- (9)
- (3)
- (8)
- (1)
- (4)
- (1)
- (1)
- (1)
- (3)
- (1)
- (1)
- (3)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (4)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (3)
- (1)
- (1)
- (1)
- (1)
- (2)
- (3)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (4)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (3)
- (1)
- (3)
- (1)
- (6)
- (1)
- (2)
- (1)
- (1)
- (1)
- (3)
- (3)
- (1)
- (2)
- (1)
- (2)
- (3)
- (1)
- (1)
- (3)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (7)
- (2)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (3)
- (3)
- (2)
- (2)
- (1)
- (5)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (8)
- (1)
- (1)
- (1)
- (1)
- (1)
- (6)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (3)
- (4)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (4)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (2)
- (5)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (6)
- (2)
- (4)
- (1)
- (3)
- (1)
- (3)
- (2)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (7)
- (3)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (4)
- (1)
- (1)
- (1)
- (5)
- (2)
- (3)
- (1)
- (2)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (2)
- (1)
- (3)
- (16)
- (1)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (5)
- (1)
- (1)
- (4)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (1)
- (1)
- (15)
- (1)
- (1)
- (1)
- (14)
- (14)
- (1)
- (1)
- (3)
- (1)
- (4)
- (1)
- (1)
- (3)
- (2)
Percent Purity
- (1)
- (1)
- (1)
- (1)
- (4)
- (4)
- (1)
- (2)
- (1)
- (3)
- (2)
- (2)
- (2)
- (4)
- (7)
- (3)
- (5)
- (1)
- (3)
- (1)
- (1)
- (26)
- (3)
- (66)
- (3)
- (34)
- (18)
- (3)
- (17)
- (71)
- (4)
- (27)
- (5)
- (1)
- (6)
- (1)
- (1)
- (2)
- (10)
- (1)
- (2)
- (1)
- (1)
- (3)
- (1)
- (4)
- (2)
- (6)
- (6)
- (59)
- (29)
- (214)
- (25)
- (161)
- (1)
- (3)
- (66)
- (18)
Physical Form
- (2)
- (11)
- (5)
- (340)
- (1)
- (2)
- (3)
- (2)
- (3)
- (3)
- (5)
- (2)
- (1)
- (2)
- (10)
- (76)
- (55)
Boiling Point
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (3)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (2)
- (1)
- (3)
- (2)
- (2)
- (4)
- (1)
- (4)
- (1)
- (2)
- (4)
- (2)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (3)
- (1)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (2)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
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![Medchemexpress LLC Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride (1:1) | 154-87-0 | 99.9% | 460.77 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000435599-Logo.png-250.jpg)
Medchemexpress LLC Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride (1:1) | 154-87-0 | 99.9% | 460.77 | 1 ML
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Thiamine pyrophosphate is the coenzyme form of Vitamin B1, acting as a required intermediate in several crucial metabolic complexes. It is essential for oxidative phosphorylation and the pentose phosphate pathway, functioning as a cofactor for α-ketoacid dehydrogenases.
- Acts as a cofactor for α-ketoacid dehydrogenases
- Inhibits ischemia-reperfusion induced oxidative damage
- Prevents Cisplatin induced cardiotoxicity
- Reduces associated oxidative stress and heart injury
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1,727
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000380850 2-ETHYL-2-PHENYLMALO 2.5MG
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1,728
eMolecules Ambeed / Gold(iii)hydroxide / 250mg / 625594274 / A522387 / / 1303-52-2 / MFCD00046173 / 247.988 / AuH3O3
Ambeed / Gold(iii)hydroxide / 250mg / 625594274 / A522387 / / 1303-52-2 / MFCD00046173 / 247.988 / AuH3O3
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1,729
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000664069 BREDININ AGLYCONE 250MG
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1,730
Chem-Impex International, Inc. 4-Chloro-2,6-diaminopyrimidine | MFCD00006097 | 5G
4-Chloro-2,6-diaminopyrimidine, MFCD00006097, 5G
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1,731
Medchemexpress LLC Copanlisib dihydrochloride | 1402152-13-9 | C23H30Cl2N8O4 | 50 MG
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Copanlisib dihydrochloride is a potent, selective, and ATP-competitive pan-class I PI3K inhibitor. It exhibits IC50 values of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ. This compound demonstrates superior antitumor activity and shows over 2,000-fold selectivity against other lipid and protein kinases, with the exception of mTOR.
- Induces apoptosis in a subset of tumor cell lines resistant to certain treatments.
- Shows complete inhibition of PI3K-mediated AKT phosphorylation in ELT3 cells at 5 nM.
- Potently inhibits cell proliferation in various human tumor cell lines, particularly those with PIK3CA-activating mutations or HER2-positive.
- Significantly increases caspase-9 activities and levels of phosphorylated p53 at Ser15 and cleaved PARP in BT20 breast cancer cells.
- Demonstrates robust antitumor activity in rat KPL4 tumor xenograft models, with high tumor growth inhibition rates.
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1,732
eMolecules Medchem Express / PKA-IN-1 / 25mg / 779715053 / HY-115732 / / 179985-52-5 / MFCD04039368 / 225.251 / C13H11N3O
Medchem Express / PKA-IN-1 / 25mg / 779715053 / HY-115732 / / 179985-52-5 / MFCD04039368 / 225.251 / C13H11N3O
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1,733
eMolecules METHYL 4-FORMYLBENZOATE 100G
5000165762 METHYL 4-FORMYLBENZOATE 100G
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1,734
Medchemexpress LLC TNF-α-IN-1 | 444287-49-4 | >99.2% | 363.75 | 250 MG
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TNF-α-IN-1 (Compound I-7) is a TNF-α inhibitor. It can be studied in research for cancers, heart disease, autoimmune disease and infections.
- Functions as a TNF-α inhibitor.
- Applicable for research in cancers.
- Applicable for research in heart disease.
- Applicable for research in autoimmune disease.
- Applicable for research in infections.
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1,735
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000382595 SELNOFLAST 250MG
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1,736
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000586305 TIMONACIC STANDARD 250MG
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1,737
Medchemexpress LLC 6-Chloropyrimidine-4 | 100G
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6-Chloropyrimidine-4 | 100G
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1,738
Medchemexpress LLC HY-10115 100mg Medchemexpress, PI-103 CAS:371935-74-9 Purity:98%
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Medchemexpress,HY-10115 100mg PI-103 CAS:371935-74-9 Formula:C19H16N4O3 PI-103 is a potent PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 also inhibits DNA-PK with an IC50 of 2 nM. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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1,739
Medchemexpress LLC TMP195 | 1314891-22-9 | 99.8% | 456.42 | 250 MG
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TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor. It has reported Ki values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7, and HDAC9, respectively. It is intended for research use only and not for sale to patients.
- Selective class IIa HDAC inhibitor.
- Blocks the accumulation of CCL2 protein in monocyte-derived macrophage differentiation cultures.
- Significantly increases CCL1 protein secretion by monocytes.
- Occupies the acetyllysine-binding site of class IIa HDACs.
- Alters the tumor microenvironment, reducing tumor burden and pulmonary metastases by modulating macrophage phenotypes in vivo.
- Induces recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors in vivo.
- Combining with chemotherapy regimens or T-cell checkpoint blockade enhances the durability of tumor reduction in vivo.
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1,740
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000382346 CG347B 250MG
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