Pyrroles
Selleck Chemical LLC BMS-986158-5mg
BMS-986158 is a potent inhibitor of BET with IC50s of 6.6 nM and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.
Selleck Chemical LLC LLY-507-5mg
LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2.
Medchemexpress LLC Hlcl-61 hydrochloride | 1158279-20-9 | 99.9% | 380.91 | C23H25ClN2O | 5 MG
HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) used for research to probe PRMT5-mediated methylation and cellular responses. It reduces cell growth in a dose-dependent manner across multiple leukemia cell lines and inhibits symmetric arginine dimethylation of histones H3 and H4, supporting studies of epigenetic regulation and oncology research.
- Targets PRMT5 to inhibit arginine methylation.
- Reduces cell proliferation in leukemia cell lines; IC50s reported by manufacturer.
- High purity suitable for research applications.
- Soluble in DMSO (50 mg/mL); insoluble in water.
- Solid, white to off-white appearance; store sealed away from moisture under recommended conditions.
Cayman Chemical Atorvastatin calcium salt hy
An HMG-CoA reductase inhibitor (IC50s = 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively)
Cayman Chemical Atorvastatin calcium salt hy
An HMG-CoA reductase inhibitor (IC50s = 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively)
Apexbio Technology LLC Sunitinib 557795-19-4 1g
Sunitinib (CAS 557795-19-4) is an orally bioavailable small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) including VEGFR1-3 PDGFR / c-kit and RET Research has shown sunitinib inhibits proliferation in nasopharyngeal carcinoma (NPC) cell lines HK1 CNE-1 CNE-2 HONE-1 and C666-1 with IC50 values ranging from approximately 2 06 to 7 57 M Additionally it induces apoptosis and G0/G1 cell cycle arrest in NPC cell lines and significantly decreases microvessel density in CNE-2 xenograft tumor models in vivo Thus sunitinib is useful for investigating pathways involved in tumor angiogenesis and proliferation
Cayman Chemical Atorvastatin calcium salt hy
An HMG-CoA reductase inhibitor (IC50s = 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively)
Cayman Chemical Atorvastatin calcium salt hy
An HMG-CoA reductase inhibitor (IC50s = 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively)
Medchemexpress LLC Atorvastatin epoxy tetrahydrofuran impurity | 873950-19-7 | 449.47 | 25 MG
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation product of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, which has the ability to effectively decrease blood lipids. Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction. The endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
- Impurity isolated oxidative degradation product
- Orally active HMG-CoA reductase inhibitor
- Effectively decreases blood lipids
- Decreases apoptosis of myocardial cells
- Down-regulates GRP78, caspase-12 and CHOP expression
Medchemexpress LLC 5-hydroxy-3-(indol-3-yl)isoindolin-1-one (S-isomer) | 2375482-51-0 | 99.5% | 516.59 Da | C31H28N6O2 | 50MG
BI-2852 is a small-molecule inhibitor that binds the KRAS switch I/II pocket and inhibits active, GTP-bound KRAS with nanomolar potency. It is intended for research use and is used as a tool compound to study KRAS-driven signaling, pERK modulation, and antiproliferative effects in KRAS-mutant cell models.
- Potent nanomolar inhibition of KRAS switch I/II pocket.
- Directly targets active GTP-bound KRAS to disrupt effector interactions.
- Suitable for in vitro studies of KRAS signaling and cell proliferation.
- High purity (>99%) suitable for biochemical and cell-based assays.
- Molecular formula C31H28N6O2 and molecular weight 516.59 Da.
- Available with supporting documentation, including COA and SDS.
Apexbio Technology LLC Sunitinib 557795-19-4 100mg
Sunitinib (CAS 557795-19-4) is an orally bioavailable small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) including VEGFR1-3 PDGFR / c-kit and RET Research has shown sunitinib inhibits proliferation in nasopharyngeal carcinoma (NPC) cell lines HK1 CNE-1 CNE-2 HONE-1 and C666-1 with IC50 values ranging from approximately 2 06 to 7 57 M Additionally it induces apoptosis and G0/G1 cell cycle arrest in NPC cell lines and significantly decreases microvessel density in CNE-2 xenograft tumor models in vivo Thus sunitinib is useful for investigating pathways involved in tumor angiogenesis and proliferation
Apexbio Technology LLC Sunitinib 557795-19-4 10mM (in 1mL DMSO)
Sunitinib (CAS 557795-19-4) is an orally bioavailable small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) including VEGFR1-3 PDGFR / c-kit and RET Research has shown sunitinib inhibits proliferation in nasopharyngeal carcinoma (NPC) cell lines HK1 CNE-1 CNE-2 HONE-1 and C666-1 with IC50 values ranging from approximately 2 06 to 7 57 M Additionally it induces apoptosis and G0/G1 cell cycle arrest in NPC cell lines and significantly decreases microvessel density in CNE-2 xenograft tumor models in vivo Thus sunitinib is useful for investigating pathways involved in tumor angiogenesis and proliferation
Cayman Chemical Losartn CarboxylIc AcId 50mg
An AT1b receptor antagonist and active metabolite of losartan; an antagonist of AT1b (Kis = 0.67 nM in COS-7 cells expressing the human receptor); selective for AT1b over AT2 (Ki = >10,000 nM in COS-7 cells expressing the human receptor); reduces U-44619-induced aggregation of platelets in isolated human platelet-rich plasma at 50 µM; reduces MAP in water-deprived rats at 1 mg/kg
Medchemexpress LLC A-1210477 | 1668553-26-1 | MFCD28399118 | 99.9% | 850.04 g/mol | C46H55N7O7S | 25MG
A-1210477 is a potent, selective small-molecule inhibitor of the anti-apoptotic protein MCL-1 used as a research tool to study apoptosis and MCL-1-dependent cancer biology. It binds MCL-1 with sub-nanomolar affinity and disrupts MCL-1 protein-protein interactions to promote apoptosis in sensitive cell lines.
- Potent, selective MCL-1 inhibition with Ki ≈ 0.45 nM.
- Disrupts MCL-1 interactions to induce programmed cell death.
- Suitable for cell-based assays and mechanistic studies of apoptosis.
- High purity for reproducible experimental results.
- Solid powder formulation with recommended cold storage for stability.
Medchemexpress LLC AZ7550 Mesylate | 2319837-99-3 | 98.7% | 5 MG
AZ7550 Mesylate is an active metabolite of AZD9291 and acts as an inhibitor of IGF1R with an IC50 of 1.6 μM. This compound exhibits a potency and selectivity profile similar to its parent compound, AZD9291, making it suitable for various research applications.
- Inhibits IGF1R with an IC50 of 1.6 μM
- Active metabolite of AZD9291
- Exhibits similar potency and selectivity profile to AZD9291
- Inhibits double mutant cell line H1975 with IC50 of 45 nM
- Inhibits activating mutant cell line PC9 with IC50 of 26 nM
- Inhibits wild type cell line LoVo with IC50 of 786 nM
- For research use only