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Filtered Search Results
Medchemexpress LLC Lurasidone | 367514-87-2 | 99.4% | C28H36N4O2S | 200 MG
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Lurasidone is an antagonist of both dopamine D2 and 5-HT7 receptors with IC50s of 1.68 nM and 0.495 nM, respectively. It also acts as a partial agonist of the 5-HT1A receptor with an IC50 of 6.75 nM. In vitro, it shows higher affinity for dopamine D2 and 5-HT2A receptors compared to other tested antipsychotics.
- Antagonist of dopamine D2 and 5-HT7 receptors
- Partial agonist of the 5-HT1A receptor
- Dose-dependently increases the ratio of DOPAC/dopamine in frontal cortex and striatum
- Inhibits conditioned avoidance response (CAR) in rats
- Inhibits tryptamine (TRY)-induced forepaw clonic seizure and p-chloroamphetamine (p-CAMP)-induced hyperthermia
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Medchemexpress LLC 4-(Hydroxymethyl)benzeneboronic acid | 59016-93-2 | 151.96 | 10 G
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4-(Hydroxymethyl)benzeneboronic acid is an important intermediate that can be used for the synthesis of other active compounds. It is also involved in the synthesis of tetrahedral boronate ester.
- Used as an important intermediate for synthesizing active compounds
- Involved in the synthesis of tetrahedral boronate ester
- Suitable for laboratory chemical applications
- Stable under recommended storage conditions
- Appears as a white to off-white solid
- For research use only
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Medchemexpress LLC Carbonic Anhydrase 2 10ug
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Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis The gene exhibits biased expression in various tissues notably in the stomach and colon Two transcript variants encoding different isoforms have been identified Carbonic Anhydrase 2 Protein Human (C-His) is the recombinant human-derived Carbonic Anhydrase 2 protein expressed by E coli with C-6 His labeled tag
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Medchemexpress LLC Boc-Asp(OMe)-fluoromethyl ketone | 187389-53-3 | MFCD03453073 | 98.0% | 263.26 g·mol⁻¹ | C11H18FNO5 | 100 MG
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Boc-Asp(OMe)-fluoromethyl ketone is a cell-permeable, broad-spectrum caspase inhibitor used as a biochemical tool to study caspase-dependent apoptosis and related processes. It inhibits caspase activity, including Fas-mediated phagocytosis and oxidative rupture, while not affecting IL-8 chemotaxis. The compound is supplied at high purity for research applications.
- Broad-spectrum caspase inhibitor for apoptosis research.
- Cell permeable, enabling intracellular enzyme inhibition.
- High purity (98.0%) for reproducible results.
- Liquid, colorless to light yellow appearance.
- Supplied as a 100 MG package for laboratory use.
- Store sealed, away from moisture; recommended in-solvent storage: -80°C (up to 6 months) or -20°C (up to 1 month).
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Accela Chembio Inc 1-benzyl-5-oxo-3-pyrrolidinecarboxylic Acid | 5g | 5733-86-8 | MFCD00085749 | 97+% | Shelf Life: 2160 Days | Moisture Sensitive
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1-benzyl-5-oxo-3-pyrrolidinecarboxylic Acid | 5g | 5733-86-8 | MFCD00085749 | 97+% | Shelf Life: 2160 Days | Moisture Sensitive
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Medchemexpress LLC (R)-1-Boc-3-propylpiperazine | 928025-57-4 | 228.34 | 100 MG
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(R)-1-Boc-3-propylpiperazine is a drug intermediate for synthesis of various active compounds. This product has not been fully validated for medical applications and is for research use only.
- Target: drug intermediate
- Pathway: others
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Medchemexpress LLC DBCO-NH-Boc | 1539290-74-8 | C23H24N2O3 | 50 MG
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DBCO-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
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Medchemexpress LLC Boc-NH-PEG-amine | ≥98.0% | 100 MG
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Boc-NH-PEG-amine (MW 5000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are compounds that link an E3 ubiquitin ligase ligand to a target protein ligand, utilizing the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is for research use only.
- PEG-based linker for PROTAC synthesis.
- Enables the degradation of target proteins.
- Utilizes the intracellular ubiquitin-proteasome system.
- Contains two ligands: E3 ubiquitin ligase and target protein.
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eMolecules 193269-78-2 | 1-BOC-3-Aminoazetidine | Combi-Blocks | MFCD01861753 | 172.228 | C8H16N2O2 | 97.000 | CC(C)(C)OC(=O)N1CC(N)C1 | 10g | 342861562
1-BOC-3-Aminoazetidine | Combi-Blocks | 193269-78-2 | MFCD01861753 | 172.228 | C8H16N2O2 | 97.000 | CC(C)(C)OC(=O)N1CC(N)C1 | 10g | 342861562
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Medchemexpress LLC Carbonic anhydrase, bovine erythrocytes | 9001-03-0 | 29.0 kDa | 10 MG
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Carbonic anhydrase, bovine erythrocytes (EC 4.2.1.1) is a ubiquitous zinc-containing metalloenzyme found in prokaryotes and eukaryotes. It catalyzes the reversible conversion of carbon dioxide to bicarbonate and protons. This enzyme can be utilized for research related to cancer, glaucoma, obesity, and epilepsy. For in vitro use, the lyophilized powder should be dissolved in ice-cold water at a concentration of 0.1 mg/mL and stored in an ice bath until use.
- Molecular weight: 29.0 kDa
- Optimal pH: 7.0-7.5
- Isoelectric point: 6.40
- Inhibitors include monovalent anions, sulfonates, sulfonamides, and imidazole
- Enzyme activity: ≥3000 U/mg solid
- Appearance: Solid
- Color: White to off-white
- Solubility: Soluble in water at ≥ 50 mg/mL
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Medchemexpress LLC Cbz-leucinyl-leucinyl-norleucinal | 133407-83-7 | 97.6% | 10 MG
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Z-LLNle-CHO (Cbz-leucinyl-leucinyl-norleucinal) is a peptidic aldehyde inhibitor of γ-secretase used in biochemical and cell-based research. It is supplied as a high-purity solid suitable for in vitro assays.
- Peptidic aldehyde inhibitor of γ-secretase.
- High purity suitable for biochemical and cell-based assays.
- Molecular weight 475.62 g/mol and formula C26H41N3O5.
- Supplied as a small, easily weighed solid for laboratory use.
- Used to study apoptosis, proteasome, and protease pathways.
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Ambeed AMBEED
5000887639 Z-11-TETRADECEN-1-YLACET 100MG
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Medchemexpress LLC (Z)-Guggulsterone | 39025-23-5 | 99.4% | 312.45 | 10 MG
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(Z)-Guggulsterone is a constituent of the Indian Ayurvedic medicinal plant *Commiphora mukul*. It inhibits the growth of human prostate cancer cells by causing apoptosis and inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis. It also acts as a potent FXR antagonist and reduces ACE2 expression and SARS-CoV-2 infection.
- Inhibits growth of human prostate cancer cells by causing apoptosis
- Inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis
- Acts as a potent FXR antagonist
- Reduces ACE2 expression
- Reduces SARS-CoV-2 infection
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Aobchem (Z)-2 3 6-trifluorobenzaldehyde oxime | 95% | CAS 1353013-21-4 | C7H4F3NO | 250mg
(Z)-2 3 6-trifluorobenzaldehyde oxime | 95% | CAS 1353013-21-4 | C7H4F3NO | 250mg
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STA Pharmaceutical DNA C(Bz) amidite | 1 g | CAS 102212-98-6 | MDL MFCD00036315
DNA C(Bz) amidite is a Amidite reagent (Subcategory: Cytosine Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 102212-98-6
- MDL: MFCD00036315
- InChIKey: PGTNFMKLGRFZDX-SALLYJDFSA-N
- Molecular Weight: 833.922761998
- Molecular Formula: C46H52N5O8P
- Purity: ≥99%
- Container Type: 30 mL Glass (28-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 50.1 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1C[C@H](N2C(N=C(C=C2)NC(C3=CC=CC=C3)=O)=O)O[C@@H]1COC(C4=CC=C(C=C4)OC)(C5=CC=C(C=C5)OC)C6=CC=CC=C6)OCCC#N)C(C)C)C
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