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Filtered Search Results
AdipoGen Bisindolylmaleimide I (5 mg)
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Chemical. CAS: 133052-90-1. Formula: C25H24N4O2. MW: 412.5. Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.
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Medchemexpress LLC DEX-maleimide | 2754462-35-4 | >99.8% | C29H36FN3O7 | 100 MG
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DEX-maleimide is a versatile coupling agent designed for the synthesis of conjugates. It plays a crucial role in conjugating single-domain antibodies with various antigens and anti-inflammatory agents, offering significant utility in biochemical research.
- Can be used to synthesize conjugates
- Useful in research on autoimmune diseases
- Facilitates the conjugation of single-domain antibodies with antigens
- Aids in the conjugation of single-domain antibodies with anti-inflammatory agents
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Strem, An Ascensus Company CAS# 1585-90-6. 1g. N-(2-Hydroxyethyl)maleimide, 99%. MFCD00465266
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CAS# 1585-90-6. 1g. N-(2-Hydroxyethyl)maleimide, 99%. MFCD00465266. Molecular Weight: 141.13. Molecular Formula: C6H7NO3. Color/form: white pwdr. Strem# 07-1010. http://www.strem.com/catalog/v/07-1010/
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Medchemexpress LLC N-Ethylmaleimide | 128-53-0 | 200 MG
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N-Ethylmaleimide (NEM) is derived from maleic acid and can alkylate free sulfhydryl groups. It acts as an irreversible cysteine protease inhibitor. NEM specifically inhibits phosphate transport in mitochondria and inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. It can be used to modify cysteine residues in proteins and peptides, and is also a deubiquitinating enzyme inhibitor.
- Irreversible cysteine protease inhibitor
- Specifically inhibits phosphate transport in mitochondria
- Inhibits prolyl endopeptidase (IC50 value of 6.3 μM)
- Modifies cysteine residues in proteins and peptides
- Deubiquitinating enzyme inhibitor
- Inhibits Akt phosphorylation
- Affects pro-caspase-3 conversion
- Promotes vascular smooth muscle cell apoptosis
- Affects PP2A activity and ROS production
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Medchemexpress LLC MC-VA-PABC-MMAE | 1818864-51-5 | 99.9% | 1230.53 | C65H99N9O14 | 5 MG
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MC-VA-PABC-MMAE is an agent-linker conjugate used in antibody-drug conjugate (ADC) research that links a peptide-based cleavable linker to the cytotoxic payload monomethyl auristatin E (MMAE). The material is supplied as a white to off-white solid for research use only and is intended for in vitro ADC assembly and evaluation.
- Contains a peptide MC-VA-PABC linker coupled to MMAE.
- High purity suitable for research applications.
- Molecular weight approximately 1230.53 Da.
- Chemical formula C65H99N9O14.
- Supplied as a solid, white to off-white in appearance.
- Store sealed at -20°C; in solvent store at -80°C for long-term.
- For research use only; not for human or clinical use.
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AdipoGen Bisindolylmaleimide I HCl
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Chemical. CAS 176504-36-2. Formula C25H24N4O2 . HCl. MW 412.5 . 36.5. Cell permeable kinase inhibitor with improved selectivity for protein kinase C PKC Ki = 10 nM. Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 GSK-3 inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.
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Medchemexpress LLC Dex-maleimide | 2754462-35-4 | MFCD00064144 | 99.8% | 557.61 g/mol | C29H36FN3O7 | 10 MG
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DEX-maleimide is a maleimide-functionalized dexamethasone derivative used as a coupling reagent for thiol-specific bioconjugation. It is applied to synthesize conjugates such as single-domain antibody (VHH)-antigen or antibody-drug conjugates, and is used in autoimmune disease research. The compound is a solid with high purity and is soluble in DMSO.
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Chem-Impex International, Inc. N-Ethylmaleimide | 128-53-0 | MFCD00005509 | 250G
N-Ethylmaleimide, 128-53-0, MFCD00005509, 250G
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Cayman Chemical FluoresceIn-5-maleImIde 50mg
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An activated fluorescent molecule (excitation: 494 nm, emission: 519 nm) used for labeling proteins; reacts optimally with sulfhydryl groups on cysteine side chains at pH 7, forming a stable thioether bond
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Medchemexpress LLC HY-D0975 10mg Medchemexpress, Sulfo-SMCC (sodium) CAS:92921-24-9 Purity:>98%
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Medchemexpress, HY-D0975 10mg Sulfo-SMCC (sodium) CAS:92921-24-9 Sulfo-SMCC sodium is a commonly used hetero-bifunctional crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Bisindolylmaleimide X hydrochloride | 145317-11-9 | MFCD04972010 | 98.9% | 460.96 g/mol | C26H25ClN4O2 | 50 MG
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Bisindolylmaleimide X hydrochloride is a small-molecule kinase inhibitor supplied as a solid for research use. It acts primarily as a potent and selective protein kinase C (PKC) inhibitor and also antagonizes cyclin-dependent kinase 2 (CDK2). The material is provided at high purity for biochemical and cell-based assays.
- Potent protein kinase C (PKC) inhibitor
- Antagonizes cyclin-dependent kinase 2 with reported IC50 ≈ 200 nM
- High purity suitable for biochemical and cell-based studies
- Solid form, available in small laboratory pack sizes
- Useful for kinase signaling and pharmacology research
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Medchemexpress LLC Doxorubicin-SMCC 25mg | 400647-59-8 | 762.76 | C39H42N2O14 | 25 MG
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Doxorubicin-SMCC is a drug-linker conjugate for antibody-drug conjugate (ADC) research that couples the anthracycline topoisomerase II inhibitor doxorubicin to a non-cleavable SMCC linker, producing a stable payload for bioconjugation and preclinical studies.
- Non-cleavable SMCC linker for stable conjugation.
- Acts as a DNA topoisomerase II inhibitor payload.
- Purity 98.8% and molecular weight 762.76.
- Orange to red solid physical form.
- Soluble in DMSO (125 mg/mL); ultrasonic recommended.
- CAS number 400647-59-8 for cross-referencing.
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Medchemexpress LLC Bisindolylmaleimide V | 113963-68-1 | 97.8% | 341.36 | 1 G
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Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 μM. It blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 μM. This product is for research use only and not sold to patients.
- Cell-permeable negative control for protein kinase C inhibition studies.
- Blocks activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo.
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Medchemexpress LLC Bisindolylmaleimide V | 113963-68-1 | 97.75% | 341.36 | 500 MG
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Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies, with an IC50 value exceeding 100 μM. It also blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo, with an IC50 of 8 μM. This product is intended for research use only and is not sold to patients.
- Cell-permeable negative control for protein kinase C inhibition studies.
- Blocks activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo.
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AdipoGen Bisindolylmaleimide V
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Chemical. CAS 113963-68-1. Formula C21H15N3O2. MW 341.4. Negative control for protein kinase C PKC inhibitors. S6K inhibitor. Necrosis inhibitor.
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