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Filtered Search Results
Medchemexpress LLC α-Amanitin | 23109-05-9 | MFCD00215842 | 99.9% | 918.97 g/mol | C39H54N10O14S | 500 UG
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α-Amanitin is a bicyclic peptide toxin that potently inhibits RNA polymerase II and is used as a research reagent and ADC payload component. The compound is supplied as a solid; it is unstable in solution and should be stored at -20°C protected from light, with solutions prepared fresh prior to use.
- Bicyclic peptide inhibitor of RNA polymerase II.
- High purity (99.9%).
- CAS number 23109-05-9.
- Molecular weight 918.97 g/mol.
- Soluble in water and DMSO with ultrasonic assistance; in vivo formulation protocols are reported.
- Store at -20°C, protect from light; unstable in solution-prepare fresh solutions.
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Medchemexpress LLC CARBONIC ANHYDRASE 2 1MG
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5000194353 CARBONIC ANHYDRASE 2 1MG
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Medchemexpress LLC Maleimide-DOTA | 1006711-90-5 | 99.6% | 526.54 | C22H34N6O9 | 25 MG
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Maleimide-DOTA is a non-cleavable antibody-drug conjugate (ADC) linker that couples payloads to antibodies via maleimide chemistry for thiol-selective conjugation. Supplied for research use, it contains a DOTA chelator enabling radiolabeling and bioconjugation applications.
- Non-cleavable maleimide-based linker.
- DOTA chelator suitable for radiolabeling and metal coordination.
- High purity (approximately 99.6%).
- Soluble in DMSO and water; sonication recommended for dissolution.
- Examples of in vivo vehicle protocols provided by manufacturer for formulation.
- Store product at -20°C; in solvent, store at -80°C for long-term stability.
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Medchemexpress LLC Monomethyl auristatin E-SMCC conjugate | 2021179-11-1 | 95.7% | 1,140.43 | C58H89N7O14S | 10 MG
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MMAE-SMCC is a drug-linker conjugate used to prepare antibody-drug conjugates (ADCs). It links monomethyl auristatin E (a potent antimitotic tubulin inhibitor) to the SMCC linker to enable covalent attachment to antibodies for targeted cytotoxic delivery.
- White to off-white solid.
- Purity 95.7%.
- Molecular weight 1,140.43 and formula C58H89N7O14S.
- CAS number 2021179-11-1.
- Solubility DMSO: 100 mg/mL (approx. 87.69 mM); ultrasonic assistance recommended.
- Storage -20 °C; protect from light; store under nitrogen.
- Unstable in solution; freshly prepare working solutions.
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Medchemexpress LLC PROTAC BRD4 DEGRADER 10MG
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5000203198 PROTAC BRD4 DEGRADER 10MG
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eMolecules 1076199-21-7 | N-Boc-PEG4-bromide | ChemScene | MFCD09840081 | 356.257 | C13H26BrNO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCBr | 1g | 572183314
N-Boc-PEG4-bromide | ChemScene | 1076199-21-7 | MFCD09840081 | 356.257 | C13H26BrNO5 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCBr | 1g | 572183314
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Medchemexpress LLC N-boc-peg4-bromide | 1076199-21-7 | MFCD09840081 | 98.0% | 356.25 g/mol | C13H26BrNO5 | 500 MG
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N-boc-peg4-bromide is a Boc-protected PEG4 bromide linker used as a PEG spacer and a reactive alkyl bromide for conjugation chemistry. It is intended for research use in small-molecule conjugation workflows, including PROTAC and cleavable linker synthesis, and has specified solubility and storage recommendations.
- Boc-protected amine with terminal bromide for alkylation.
- Designed as a PEG4 spacer to increase solubility and flexibility.
- Soluble in DMSO; recommended concentration up to 100 mg/mL with ultrasonic assistance.
- Purity ≥98.0% as supplied for research applications.
- Available in multiple pack sizes, including a 500 mg pack.
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Medchemexpress LLC β-amanitin | 21150-22-1 | MFCD00151212 | >98.0% | 918.96 g/mol | C39H54N10O14S | 1 MG
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β-Amanitin is a cyclic peptide toxin isolated from Amanita phalloides that potently inhibits eukaryotic RNA polymerase II and, to a lesser extent, RNA polymerase III, blocking mRNA synthesis and protein production. It is used as a biochemical research reagent to study transcription, RNA polymerase function, and as a cytotoxic payload in antibody-drug conjugate research.
- Potent inhibitor of RNA polymerase II and III.
- High purity (>98%) suitable for biochemical studies.
- Soluble in DMSO at high concentration for stock preparation.
- Appropriate for use as an ADC cytotoxic payload or molecular biology tool.
- Supplied in small research quantities for laboratory applications.
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Medchemexpress LLC Doxorubicin-SMCC 25mg | 400647-59-8 | 762.76 | C39H42N2O14 | 25 MG
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Doxorubicin-SMCC is a drug-linker conjugate for antibody-drug conjugate (ADC) research that couples the anthracycline topoisomerase II inhibitor doxorubicin to a non-cleavable SMCC linker, producing a stable payload for bioconjugation and preclinical studies.
- Non-cleavable SMCC linker for stable conjugation.
- Acts as a DNA topoisomerase II inhibitor payload.
- Purity 98.8% and molecular weight 762.76.
- Orange to red solid physical form.
- Soluble in DMSO (125 mg/mL); ultrasonic recommended.
- CAS number 400647-59-8 for cross-referencing.
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Sigma Aldrich Fine Chemicals Biosciences Cytochalasin B from Drechslera dematioidea | 14930-96-2 | MFCD00077704 | 5mg
Cytochalasin B from Drechslera dematioidea | Purity: ≥98% | Mol Wt: 479.61 | 14930-96-2 | MFCD00077704 | 5mg
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eMolecules 2471978-97-7 | Medchem Express | BAY-298 | 5mg | 694124969 | HY-130249 | 473.93 | C27H21ClFN3O2
AstaTech | ETHYL 5-AMINO-2-CHLOROPYRIMIDINE-4-CARBOXYLATE | 0.1g | 779513136 | O11802 | 95.000 | 59950-50-4 | MFCD22377545 | 201.610 | C7H8ClN3O2
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eMolecules 1660114-31-7 | Medchem Express | NIK SMI1 | 5mg | 451965253 | HY-112433 | 365.389 | C20H19N3O4
Medchem Express | TED-347 | 1mg | 527574266 | HY-125269 | 2378626-29-8 | 313.700 | C15H11ClF3NO
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Chem-Impex International, Inc. N-Vinyl-2-Pyrrolidone 99%, Versatile Monomer, Liquid Form
N-Vinyl-2-pyrrolidone, 99%, 4 kg is a versatile monomer crucial for synthesizing polymers and copolymers. Its excellent solubility in water and organic solvents makes it essential in UV-curable coatings, inks, and adhesives, enhancing their durability and adhesion. Additionally, it acts as a binder in pharmaceuticals, improving active ingredient solubility. The product is stabilized to prevent spontaneous polymerization, ensuring stability during storage and use, setting it apart from other chemicals.
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Medchemexpress LLC Poly(2-hydroxyethyl methacrylate) (Mv 300000) | 25249-16-5 | 300000 | 5 G
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Poly(2-hydroxyethyl methacrylate) (Mv 300000) | 25249-16-5 | 300000 | 5 G
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Medchemexpress LLC Boc-NH-PEG2 | 139115-91-6 | 205.25 | 1 G
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This PEG-based PROTAC linker can be used in the synthesis of PROTACs. PROTACs are compounds containing two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets the desired protein. These compounds utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs degrade target proteins using the ubiquitin-proteasome system
- PROTACs consist of two different ligands connected by a linker
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