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Filtered Search Results
Medchemexpress LLC Boc-NH-PEG4-Ms | 1447797-72-9 | 98.0% | C14H29NO8S | 100 MG
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Boc-NH-PEG4-MS is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These compounds utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is intended for laboratory research and the manufacture of substances.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Leverages the ubiquitin-proteasome system to degrade target proteins
- Appears as a colorless to light yellow liquid
- NMR and LCMS spectra consistent with structure
- Stable in pure form: -20°C for 3 years; 4°C for 2 years
- Stable in solvent: -80°C for 6 months; -20°C for 1 month
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Medchemexpress LLC Boc-NH-PEG8-CH2CH2COOH | 1334169-93-5 | MFCD13185254 | 99.94% | C24H47NO12 | 250 MG
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Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are innovative molecules that harness the cell's ubiquitin-proteasome system to selectively degrade target proteins, offering a novel approach in drug discovery.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.3% | 1107.26 | C60H70N10O11 | 10 MG
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Pasireotide acetate is a somatostatin receptor agonist peptide supplied as the acetate salt for research and preclinical studies. It is commonly used to study hormone secretion and endocrine disease models, and is provided with supporting analytical data such as COA, HNMR, and LCMS.
- Somatostatin receptor agonist peptide for research use
- Acetate salt form, suitable for aqueous preparations
- High purity (~99.3%) as reported by manufacturer
- Available in multiple pack sizes, including 10 MG
- Used in studies of GH, IGF-I, and ACTH secretion and endocrine disease models
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Medchemexpress LLC J147 | 1146963-51-0 | 99.5% | 350.34 | 100 MG
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(E/Z)-J147 is an exceptionally potent, orally active neuroprotective agent that enhances cognitive function. It can easily cross the blood-brain barrier (BBB) and shows potential for the study of Alzheimer's disease (AD). It inhibits monoamine oxidase B (MAO B) and the dopamine transporter.
- Neuroprotection and cognitive enhancement
- Readily passes the blood-brain barrier (BBB)
- Inhibits monoamine oxidase B (MAO B) with an EC50 value of 1.88 μM and the dopamine transporter with an EC50 value of 0.649 μM
- Shows potential for the study of Alzheimer's disease (AD)
- Promotes HT22 and primary cell survival in a dose-dependent manner, with an EC50 value range of 0.06-0.115 μM
- Enhances memory and dendritic spine number in old mice when administered in their diet at 200 ppm for 6 months
- Half-life (t1/2) in plasma is 1.5 hours and in the brain is 2.5 hours after a single oral dose of 20 mg/kg
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Chemscene CHEMSCENE
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5000576098 S- 1R 2S 5R-2-ISOPROPYL-5-M 1G
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Medchemexpress LLC 5-(hydroxymethyl)cytidine | 19235-17-7 | MFCD26523159 | ≥99.0% | 273.24 | C10H15N3O6 | 10 MG
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5-(Hydroxymethyl)cytidine is a cytidine nucleoside analogue used as a research reagent to study DNA and RNA modifications, cell-cycle effects, and nucleoside metabolism. Supplied as a small-quantity solid for preparing stock solutions and in vitro assays.
- High purity (≥99.0%).
- Molecular formula C10H15N3O6; molecular weight 273.24.
- CAS number 19235-17-7.
- Soluble in water (~20.83 mg/mL); sonication may be required.
- Store at -20°C as a sealed solid; in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month.
- Used to probe DNA damage and cell-cycle pathways as a nucleoside antimetabolite/analog.
- Available in 1 mg, 5 mg, and 10 mg quantities for preparing stock solutions.
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Medchemexpress LLC Boc-NH-PEG7-azide | 50MG
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Boc-NH-PEG7-azide | 50MG
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Medchemexpress LLC (Rac)-NNC 55-0396 | 2517420-92-5 | 96.2% | C30H40Cl2FN3O2 | 5 MG
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(Rac)-NNC 55-0396 is the racemate of NNC 55-0396 (HY-50722) and is intended for research use only. This product is not classified as a hazardous substance or mixture and is stable under recommended storage conditions.
- Not a hazardous substance or mixture
- Stable under recommended storage conditions
- Recommended storage temperature: -20°C, sealed, away from moisture
- Detailed safety information is available for handling, first aid, fire fighting, and accidental release
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Aobchem AOBCHEM
5001006346 2-FLUORO-4-METHYL-5-NITROPHEN
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Medchemexpress LLC (Rac)-PF-998425 | 1076225-27-8 | 99.68% | C14H14F3NO | 10 MM X 1 ML
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(Rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist, exhibiting an IC50 of 26 nM in AR binding assays and 90 nM in cellular assays. It demonstrates low activity on common receptors and enzymes, including the progesterone receptor. This compound is suitable for research related to sebum control and androgenetic alopecia.
- Potent, selective nonsteroidal androgen receptor (AR) antagonist
- Exhibits IC50 values of 26 nM in AR binding and 90 nM in cellular assays
- Low activity on common receptors and enzymes, including progesterone receptor
- Suitable for research on sebum control and androgenetic alopecia
- Rapidly metabolized in rat liver microsomes (t1/2=4 min, CLint=350 (μL/min)/mg protein)
- Mean systemic plasma clearance is 40 (mL/min)/kg
- Mean apparent volume of distribution at steady state is 6.5 L/kg
- Mean terminal phase half-life is 2.6 hours
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Medchemexpress LLC FABPs ligand 6 | 2988135-14-2 | 99.9% | C28H27FN2O3 | 100 MG
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FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM for FABP5 and 20 nM for FABP7. This compound rescues mitochondrial function by blocking voltage-dependent anion channel (VDAC)-1-dependent mitochondrial macropore formation, a mechanism involved in FABP5-mediated injury. It can be used for multiple sclerosis research, improving EAE severity and attenuating oxidative levels and inflammatory responses in mouse models.
- FABP5 and FABP7 inhibitor
- Rescues mitochondrial function
- Attenuates oxidative levels
- Inhibits inflammatory responses
- Protects oligodendrocytes
- Suitable for multiple sclerosis research
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Aobchem AOBCHEM
5001090576 4-BROMOPHENYL PYRROLIDIN-1-Y
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Medchemexpress LLC Azido-PEG4-Boc | 581066-04-8 | 97% | C15H29N3O6 | 1 G
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Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent and can exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
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Chemscene CHEMSCENE
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5000575869 S-3-TERT-BUTOXYCARBONYL AM 25G
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![eMolecules 288154-64-3 | N-[4-(Pyrrolidine-1-sulfonyl)-phenyl]-acetamide | Oakwood Chemical | MFCD00592754 | 268.330 | C12H16N2O3S | 97.000 | CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 | 5g | 537692703](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502150035.JPG-250.jpg)
eMolecules 288154-64-3 | N-[4-(Pyrrolidine-1-sulfonyl)-phenyl]-acetamide | Oakwood Chemical | MFCD00592754 | 268.330 | C12H16N2O3S | 97.000 | CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 | 5g | 537692703
N-[4-(Pyrrolidine-1-sulfonyl)-phenyl]-acetamide | Oakwood Chemical | 288154-64-3 | MFCD00592754 | 268.330 | C12H16N2O3S | 97.000 | CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 | 5g | 537692703
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