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Filtered Search Results
Ambeed 5Chloro1methylimidazole
5-Chloro-1-methylimidazole, 872-49-1, 97%
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Medchemexpress LLC Protac BRD4 degrader-9 | 2417370-42-2 | 98.2% | 1312.50 g/mol | C59H71F2N9O15S4 | 5 MG
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Protac BRD4 degrader-9 is a BRD4-targeting PROTAC small-molecule degrader provided for research use in targeted protein degradation and epigenetic studies. It is supplied as a powder with recommended frozen storage and is intended for biochemical and cellular assays.
- Target: BRD4.
- Molecular formula: C59H71F2N9O15S4.
- Molecular weight: 1312.50 g/mol.
- Purity: 98.2%.
- Recommended storage: powder at -20°C; in solvent at -80°C (6 months) or -20°C (1 month).
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Ambeed 4 4Hydroxyphenyl cyclohexanone
4-(4-Hydroxyphenyl)cyclohexanone, 105640-07-1, 95%
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Ambeed 1 2Hydroxyethyl 1Hpyrrole2 5di
1-(2-Hydroxyethyl)-1H-pyrrole-2,5-dione, 1585-90-6, 97%
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Medchemexpress LLC (Z)-Guggulsterone | 39025-23-5 | 99.4% | 312.45 | 25 MG
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(Z)-Guggulsterone, a constituent of the Indian Ayurvedic medicinal plant Commiphora mukul, has been shown to inhibit the growth of human prostate cancer cells by inducing apoptosis. It also inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis. Furthermore, (Z)-Guggulsterone acts as a potent FXR antagonist and can reduce ACE2 expression and SARS-CoV-2 infection.
- Inhibits growth of human prostate cancer cells by inducing apoptosis.
- Inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis.
- Acts as a potent FXR antagonist.
- Reduces ACE2 expression and SARS-CoV-2 infection.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000295325 E Z -ICERGUASTAT 10MG
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eMolecules EMOLECULES INC
NC3963068 2-HYDROXYETHYL BICYCLO2.2.1HEP
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Medchemexpress LLC J147 | 1146963-51-0 | 99.5% | 350.34 | 100 MG
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(E/Z)-J147 is an exceptionally potent, orally active neuroprotective agent that enhances cognitive function. It can easily cross the blood-brain barrier (BBB) and shows potential for the study of Alzheimer's disease (AD). It inhibits monoamine oxidase B (MAO B) and the dopamine transporter.
- Neuroprotection and cognitive enhancement
- Readily passes the blood-brain barrier (BBB)
- Inhibits monoamine oxidase B (MAO B) with an EC50 value of 1.88 μM and the dopamine transporter with an EC50 value of 0.649 μM
- Shows potential for the study of Alzheimer's disease (AD)
- Promotes HT22 and primary cell survival in a dose-dependent manner, with an EC50 value range of 0.06-0.115 μM
- Enhances memory and dendritic spine number in old mice when administered in their diet at 200 ppm for 6 months
- Half-life (t1/2) in plasma is 1.5 hours and in the brain is 2.5 hours after a single oral dose of 20 mg/kg
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Medchemexpress LLC Boc-aminooxy-PEG2-pr | 50MG
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Boc-aminooxy-PEG2-pr | 50MG
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Medchemexpress LLC Amino-PEG10-Boc | 1818294-42-6 | 99.73% | C27H55NO12 | 250 MG
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Amino-PEG10-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These PROTACs harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Connects two different ligands via a linker
- One ligand binds to an E3 ubiquitin ligase, the other to the target protein
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Medchemexpress LLC Azido-PEG12-acid | 2152679-71-3 | 99.8% | C27H53N3O14 | 250 MG
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Azido-PEG12-acid is a PEG-based PROTAC linker that functions as a click chemistry reagent. It contains an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilize the intracellular ubiquitin-proteasome system to degrade target proteins.
- Used in the synthesis of PROTACs
- Click chemistry reagent with Azide group
- Participates in CuAAc reactions
- Participates in SPAAC reactions
- Utilizes the ubiquitin-proteasome system for protein degradation
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Medchemexpress LLC Boc-amido-PEG9-amine | 890091-43-7 | ≥98.0% | C25H52N2O11 | 250 MG
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Boc-amido-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs operate by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Not for sale to patients
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Medchemexpress LLC (Rac)-Razpipadon | 1643462-93-4 | 97.1% | C19H17F2N3O4 | 25 MG
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(Rac)-Razpipadon, also known as PW0464, is a nanomolar potent complete G protein biased ligand and a noncatechol D1R agonist. It exhibits agonist activity at D5R and wild-type human D1R in HEK293 cells and shows complete G protein bias without activity for D1R-mediated β-arrestin recruitment. This compound is intended for research use only.
- Nanomolar potent complete G protein biased ligand
- Noncatechol D1R agonist with EC50 of 5.8 nM (Gs-cAMP)
- Agonist activity at D5R (EC50 12 nM) and human D1R (EC50 5.3 nM) in HEK293 cells
- Exhibits complete G protein bias in vitro
- Appears as a white to off-white solid
- Soluble in DMSO at 25 mg/mL
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Medchemexpress LLC Boc-Aminooxy-PEG4-Tos | 1807539-01-0 | C20H33NO9S | 250 MG
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Boc-Aminooxy-PEG4-Tos is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are innovative molecules that harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins by linking a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system for selective protein degradation
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Medchemexpress LLC Hydroxymethyl dasatinib | 910297-58-4 | MFCD18252610 | 98.0% | 504.00 g/mol | C22H26ClN7O3S | 5 MG
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Hydroxymethyl dasatinib is the M24 benzylhydroxy metabolite of dasatinib and is supplied as a small-molecule research reagent for in vitro studies. It has been reported to inhibit proliferation of K562 chronic myeloid leukemia cells with an IC50 of 46.7 nM. This compound is intended for research use only and not for human or clinical applications.
- Benzylhydroxy metabolite of dasatinib.
- Reported IC50 of 46.7 nM in K562 cells.
- Small-molecule research reagent for in vitro studies.
- Molecular weight 504.00 g/mol.
- Chemical formula C22H26ClN7O3S.
- CAS number 910297-58-4.
- Available as 5 MG package.
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