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Filtered Search Results
![Medchemexpress LLC Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)- | 901787-88-0 | 98.0% | 451.28 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402178-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)- | 901787-88-0 | 98.0% | 451.28 | 25 MG
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(Z)-4EGI-1 is the Z-isomer of 4EGI-1, functioning as an inhibitor of eIF4E/eIF4G interaction and translation initiation. It binds effectively to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM, and exhibits anticancer activity. In vitro studies with melanoma cells showed that treatment with (Z)-4EGI-1 significantly reduced the expression of regulatory proteins such as cyclin D1, cyclin E, and Survivin, while housekeeping proteins remained unaffected. It also inhibits the proliferation of cancer cells.
- Functions as an inhibitor of eIF4E/eIF4G interaction and translation initiation.
- Binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM.
- Exhibits anticancer activity.
- Reduces expression of regulatory proteins like cyclin D1, cyclin E, and Survivin.
- Inhibits the proliferation of cancer cells with IC50 values of 15.3 μM for breast cells and 11.6 μM for melanoma cells.
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Medchemexpress LLC Eltanexor Z-isomer | 1642300-78-4 | 96.0% | 428.29 g·mol⁻¹ | C17H10F6N6O | 25 MG
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Eltanexor Z-isomer is the less-active geometric isomer of the exportin-1 (XPO1/CRM1) inhibitor eltanexor, supplied for research use. The compound has documented in vitro activity across multiple cell lines and is offered as both solid material and ready-to-use DMSO solutions. Key analytical identifiers include a purity near 96%, molecular weight 428.29 g·mol⁻¹, and formula C17H10F6N6O.
- Provided for research use only.
- Reported purity of 95.98%.
- Molecular weight 428.29 g·mol⁻¹ and formula C17H10F6N6O.
- Available as solid and DMSO solution formats.
- Suitable for in vitro assay development and pharmacology studies.
- Documented activity across multiple cell lines.
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Medchemexpress LLC Z-3578 | 473687-20-6 | 98.72% | 467.37 | 50 MG
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Z-3578 | 473687-20-6 | 98.72% | 467.37 | 50 MG
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Cayman Chemical Tetratriaconta16 Z 19 Z 22 Z
A C34:6 VLCPUFA whose specific biological actions are largely unknown
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Medchemexpress LLC Methyl S---N-Z-aziri 250mg | 104597-98-0 | 235.24 | C12H13NO4 | 250 MG
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Methyl (S)-(-)-N-Z-aziridine-2-carboxylate is a chiral synthetic intermediate used in pharmaceutical and agrochemical research. Supplied in a 250 mg research pack with a reported purity of 98.0%, it is intended for stereoselective transformations and small-scale route development.
- Chiral building block for enantioselective synthesis.
- High reported purity (98.0%).
- Supplied in research-scale pack sizes for flexible use.
- Suitable for medicinal chemistry and process development applications.
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Medchemexpress LLC (Z)-11-octadecenal | 4273-95-4 | MFCD18642088 | 95.9% | 266.46 g/mol | C18H34O | 100mg
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(Z)-11-Octadecenal is a female pheromone with diurnal stability isolated from the pheromone glands of female rice leaffolder moths[1]
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Medchemexpress LLC (Z)-Zolucatetide ((Z)-FOG-001; I-67) | 98.2% | 2076.39 | 5 MG
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(Z)-Zolucatetide is a structural isomer of Zolucatetide and acts as a potent β-catenin inhibitor with an IC50 of <50 nM. It inhibits β-catenin and T-cell factor (TCF) transcription factor interaction, suppresses cell proliferation, and induces cell cycle arrest in target cells. It has shown anti-tumor efficacy in mice bearing COLO320DM colon cancer cell xenografts and can be used for the study of colon cancer.
- Potent β-catenin inhibitor with an IC50 of less than 50 nM.
- Inhibits β-catenin and T-cell factor (TCF) transcription factor interaction.
- Suppresses cell proliferation.
- Induces cell cycle arrest in target cells.
- Exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell xenografts.
- Useful for the study of colon cancer.
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eMolecules (S)-METHYL 3-(CBZ-AMINO)BUTANOATE | 83460-84-8 | MFCD22573797 | 1g
AstaTech | (S)-METHYL 3-(CBZ-AMINO)BUTANOATE | 1g | 164727976 | 62366 | 97.000 | 83460-84-8 | MFCD22573797 | 251.282 | C13H17NO4
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Medchemexpress LLC (E/Z)-Zotiraciclib citrate | 1204918-73-9 | C29H32N4O8 | 10 MM 1 ML
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(E/Z)-Zotiraciclib citrate is a potent inhibitor of CDK2, JAK2, and FLT3, intended for research use only. It appears as a solid with an off-white to light yellow color and has a high purity of 99.83%. It is soluble in DMSO at 250 mg/mL, with various in vivo dissolution protocols available.
- Potent CDK2 inhibitor
- Potent JAK2 inhibitor
- Potent FLT3 inhibitor
- For research use only
- Off-white to light yellow solid appearance
- High purity of 99.83%
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Medchemexpress LLC (E/Z)-Zotiraciclib (hydrochloride) | 1321626-25-8 | C23H25ClN4O | 25 MG
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(E/Z)-Zotiraciclib ((E/Z)-TG02) is an orally active inhibitor of CDK2, JAK2, and FLT3 with IC50s of 13, 73, and 56 nM, respectively. It effectively inhibits the proliferation of cancer cells and can be used for cancer research.
- Potent inhibitor of CDK2, JAK2, and FLT3
- Effectively inhibits proliferation of cancer cells
- Can be used for cancer research
- Inhibits CDK2 biomarker pRb
- Demonstrates tumor growth inhibition in animal models
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Medchemexpress LLC 11(Z),14(Z)-Eicosadienoic acid | 5598-38-9 | ≥98.0% | 308.50 | 25 MG
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11(Z),14(Z)-Eicosadienoic acid is an unsaturated fatty acid. It inhibits the binding of [3H] leukotriene B4 (LTB4) to pig neutrophil membranes with a Ki of 3 μM and exhibits inflammatory activities. This compound is intended for research use only.
- Unsaturated fatty acid
- Inhibits [3H] leukotriene B4 (LTB4) binding to pig neutrophil membranes
- Exhibits inflammatory activities
- For research use only
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Medchemexpress LLC (E/Z)-Icerguastat ((E/Z)-Sephin1) | 13098-73-2 | 99.4% | 196.64 | 25 MG
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(E/Z)-Icerguastat ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). It can be used for protein misfolding diseases research.
- Selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A).
- Applicable for research in protein misfolding diseases.
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Medchemexpress LLC Z-Leu-Leu-Nle-CHO | 133407-83-7 | 97.6% | 5 MG
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Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a peptide aldehyde research reagent used as a γ-secretase inhibitor in biochemical and cell biology studies. It inhibits γ-secretase activity and has been reported to induce caspase- and ROS-dependent apoptosis by interfering with Akt-mediated survival pathways. The compound is supplied in small milligram quantities for laboratory research and assay preparation.
- Peptide aldehyde inhibitor of γ-secretase
- Used to study apoptosis and Akt signaling pathways
- High purity suitable for research applications
- Multiple small milligram package sizes available
- Soluble in common organic solvents for assay preparation
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Medchemexpress LLC Endoxifen Z-isomer hydrochloride | 1032008-74-4 | 99.67% | 409.95 | 5 MG
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Endoxifen Z-isomer hydrochloride is an orally active Tamoxifen metabolite that acts as a selective estrogen receptor modulator. It is significantly more potent than Tamoxifen, with 100-fold greater efficacy. This compound inhibits PKCβ1 kinase activity and demonstrates anticancer properties against hormone-resistant metastatic breast cancer.
- Inhibits PKCβ1 kinase activity
- Reduces AKTSer473 phosphorylation
- Diminishes AKT substrate phosphorylation
- Induces apoptosis
- Potent antiproliferative activity against MCF7AC1 and MCF7LR cell lines
- Shows better antitumor efficacy in MCF7LR resistant mouse model
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Cayman Chemical 9 Z 11 E 13 EOctadecatrienoic
α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.
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