Pyrrolidines
2,3-Bis(2,4,5-trimethyl-3-thienyl)maleimide 97.0+%, TCI America™
CAS: 220191-36-6 Molecular Formula: C18H19NO2S2 Molecular Weight (g/mol): 345.48 MDL Number: MFCD00142790 InChI Key: OHZCQTZIDIVCPI-UHFFFAOYSA-N PubChem CID: 22023748 IUPAC Name: 3,4-bis(2,4,5-trimethylthiophen-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione SMILES: CC1=C(C)C(=C(C)S1)C1=C(C(=O)NC1=O)C1=C(C)SC(C)=C1C
Clemizole Hydrochloride 98.0+%, TCI America™
CAS: 1163-36-6 Molecular Formula: C19H21Cl2N3 Molecular Weight (g/mol): 362.30 MDL Number: MFCD00051435 InChI Key: DNFMJYXRIMLMBZ-UHFFFAOYSA-N Synonym: 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)benzimidazole Hydrochloride PubChem CID: 5309446 IUPAC Name: hydrogen 1-[(4-chlorophenyl)methyl]-2-[(pyrrolidin-1-yl)methyl]-1H-1,3-benzodiazole chloride SMILES: [H+].[Cl-].ClC1=CC=C(CN2C(CN3CCCC3)=NC3=CC=CC=C23)C=C1
eMolecules Azide-PEG8-Alcohol | 352439-36-2 | MFCD08274607 | 5g
Broadpharm | Azide-PEG8-Alcohol | 5g | 309209143 | BP-21075 | 98.000 | 352439-36-2 | MFCD08274607 | 395.453 | C16H33N3O8
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Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | C25H25ClN4O2 | 10MG
Bisindolylmaleimide I hydrochloride is a research-grade protein kinase C (PKC) inhibitor supplied as the hydrochloride salt for laboratory use. It is intended for biochemical and cell-based assays and for analytical applications; not for human or veterinary use.
- Reversible, cell-permeable inhibitor of PKC with nanomolar potency.
- Suitable for biochemical and cell-based assays.
- Hydrochloride salt improves solubility in aqueous media.
- High reported purity for analytical applications.
- Intended for research use only and method development.
Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | 448.94 | 50 MG
Bisindolylmaleimide I hydrochloride is a cell-permeable and reversible PKC inhibitor, with IC50 values of 20 nM for PKCα, 17 nM for PKCβI, 16 nM for PKCβII, and 20 nM for PKCγ. It also functions as a GSK-3 inhibitor. This product is intended for research use only.
- Acts as a cell-permeable and reversible PKC inhibitor
- Inhibits multiple PKC isoforms including alpha, beta I, beta II, and gamma
- Demonstrates activity as a GSK-3 inhibitor
- Capable of inhibiting alpha-thrombin-induced P47 phosphorylation
- Inhibits DNA synthesis in quiescent cells
- Reduces GSK-3 activity in adipocyte lysates
- Inhibits exosome and microvesicle release from PC3 cells
- Enhances the cytotoxicity of 5-fluorouracil
Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | 448.94 | 100 MG
Bisindolylmaleimide I hydrochloride is a cell-permeable and reversible protein kinase C (PKC) inhibitor with IC50 values of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively. It also acts as a glycogen synthase kinase-3 (GSK-3) inhibitor, making it suitable for a wide range of research applications.
- Cell-permeable and reversible protein kinase C inhibitor
- Glycogen synthase kinase-3 inhibitor
- Inhibits α-thrombin-induced P47 phosphorylation
- Inhibits DNA synthesis in quiescent swiss 3T3 cells
- Reduces GSK-3 activity in adipocyte lysates
- Inhibits exosome and microvesicle release from PC3 cells
- Enhances cytotoxicity of 5-fluorouracil
- Reduces increased NLRP3, P-PKCɑ, and PKCɑ levels in mechanical ventilation group
- Reduces Quinpirole-induced vomiting in shrews
- Blocks Quinpirole-mediated ERK1/2 phosphorylation in shrew brainstems
Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | MFCD00236429 | 98.4% | 448.94 | C25H25ClN4O2 | 5 MG
Bisindolylmaleimide I hydrochloride is a cell-permeable, reversible protein kinase C (PKC) inhibitor that also shows activity against GSK-3. It is supplied as a powder for research and analytical use, with reported potency in the low nanomolar range against PKC isoforms and a high reported purity.
- Cell-permeable, reversible PKC inhibitor
- Potent activity: IC50 ≈ 16-20 nM for PKC isoforms
- Also reported to inhibit GSK-3
- High purity (reported 98.4%)
- Supplied as a powder in small analytical pack sizes (for example, 1 mg, 5 mg, 10 mg)
- Recommended storage: powder at 4°C or -20°C; solutions at -20°C or -80°C
Medchemexpress LLC (R)-5-Oxopyrrolidine-2-carboxylic acid | 4042-36-8 | 129.11 | 25 G
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. It can be used in the research of metabolic syndrome and end-stage renal disease.
- Cyclic derivative of D-glutamate
- Used in research of metabolic syndrome
- Used in research of end-stage renal disease
Medchemexpress LLC (R)-5-Oxopyrrolidine-2-carboxylic acid | 4042-36-8 | 129.11 | 1 ML
(R)-5-Oxopyrrolidine-2-carboxylic acid, also known as D-Pyroglutamic acid, is a cyclic derivative of D-glutamate. It is used in research studies related to metabolic syndrome and end-stage renal disease.
- Cyclic derivative of D-glutamate
- Used in metabolic syndrome research
- Used in end-stage renal disease research
- Purity of 98.0%
- Molecular weight of 129.11
- Formula is C5H7NO3
- Appears as a white to off-white solid
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC (R)-5-Oxopyrrolidine-2-carboxylic acid | 4042-36-8 | 129.11 | 5 G
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. This compound is suitable for research pertaining to metabolic syndrome and end-stage renal disease.
- Cyclic derivative of D-glutamate
- Utilized in research pertaining to metabolic syndrome and end-stage renal disease
- Appears as a white to off-white solid
- Classified as a ketone, aldehyde, and acid
- Functions as an endogenous metabolite
Medchemexpress LLC (R)-5-Oxopyrrolidine-2-carboxylic acid | 4042-36-8 | 129.11 | 10 G
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. It can be used in the research of metabolic syndrome and end-stage renal disease.
- For research use only.
eMolecules (S)-2-((tert-Butoxycarbonyl)amino)-2-(m-tolyl)acetic acid | 1217677-36-5 | MFCD01632531 | 250mg
Ambeed | (S)-2-((tert-Butoxycarbonyl)amino)-2-(m-tolyl)acetic acid | 250mg | 490531420 | A199741 | | 1217677-36-5 | MFCD01632531 | 265.309 | C14H19NO4
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eMolecules 1-Cbz-4,4-dimethyl-pyrrolidine-2-carboxylic acid | 2097068-36-3 | MFCD30735900 | 1g
J & W PharmLab LLC | 1-Cbz-4,4-dimethyl-pyrrolidine-2-carboxylic acid | 1g | 553409797 | 75R0681 | 97.000 | 2097068-36-3 | MFCD30735900 | 277.320 | C15H19NO4
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AdipoGen Bisindolylmaleimide I HCl
Chemical. CAS 176504-36-2. Formula C25H24N4O2 . HCl. MW 412.5 . 36.5. Cell permeable kinase inhibitor with improved selectivity for protein kinase C PKC Ki = 10 nM. Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 GSK-3 inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.