Quinolines and derivatives
Medchemexpress LLC Tacalcitol monohydrate | 93129-94-3 | MFCD13184757 | 99.9% | 434.65 g/mol | C27H46O4 | 10 MG
Tacalcitol monohydrate is a vitamin D3 analog (1,24(R)-dihydroxyvitamin D3 monohydrate) used as a research reagent to modulate vitamin D receptor (VDR) signaling and calcium regulation. It is applied in studies of bone metabolism, skin disorders, inflammation, and oncology to probe VDR-mediated pathways.
- High purity (99.85%).
- Vitamin D3 analog that modulates vitamin D receptor activity.
- Applicable to in vitro and in vivo research on bone metabolism, skin disease, inflammation, and cancer.
- Supplied as a monohydrate solid for consistent dosing.
- Molecular weight 434.65 g/mol; formula C27H46O4.
Medchemexpress LLC Sulfo-ara-F-NMN | 1374663-29-2 | 99.4% | 25 MG
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN) that selectively activates SARM1 and inhibits CD38 with an IC50 of approximately 10 μM. This compound stimulates intracellular cyclic ADP-ribose (cADPR) production and subsequently activates SARM1 to generate cyclic ADP-ribose, leading to non-apoptotic cell death. It is intended for research use only.
- Mimetic of nicotinamide mononucleotide (NMN)
- Selectively activates SARM1
- Inhibits CD38 (IC50 around 10 μM)
- Induces intracellular cyclic ADP-ribose (cADPR) production
- Activates SARM1 to produce cyclic ADP-ribose
- Induces non-apoptotic cell death
- For research use only
Medchemexpress LLC CH-223191 | 301326-22-7 | 99.8% | 200 MG
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). It inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and also inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM.
- Potent and specific antagonist of aryl hydrocarbon receptor (AhR)
- Inhibits TCDD-mediated nuclear translocation and DNA binding of AhR
- Inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM
- Inhibits TCDD-caused cytochrome P450 1A1 mRNA expression
- Suppresses cytochrome P450 1A1 expression in liver
- Reduces activity of AST and ALT
- Molecular weight: 333.39
- Molecular formula: C19H19N5O
- Appearance: solid, yellow to orange
Medchemexpress LLC Mycophenolate mofetil | 128794-94-5 | 99.8% | 200 MG
Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. It inhibits de novo purine synthesis by inhibiting inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil exhibits selective lymphocyte antiproliferative effects on both T and B cells, which prevents antibody formation.
TARGETMOL CHEMICALS INC DMOG 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. DMOG (Dimethyloxalylglycine), an antagonist of the alpha-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase. Purity 98.26%
Medchemexpress LLC Ipragliflozin | 761423-87-4 | 404.45 | 200 MG
Ipragliflozin | 761423-87-4 | 404.45 | 200 MG
Medchemexpress LLC Infigratinib | 872511-34-7 | 99.8% | 560.48 | 200 MG
Infigratinib, also known as BGJ-398 or NVP-BGJ398, is a potent inhibitor of the Fibroblast Growth Factor Receptor (FGFR) family. It targets FGFR1, FGFR2, FGFR3, and FGFR4 with high efficacy, making it suitable for various research applications.
- Potent inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4
- Inhibits proliferation of FGFR-dependent BaF3 cells
- Effective against FGFR2-mutant endometrial cancer cells
- Extensively studied in clinical trials for multiple cancers and conditions
Medchemexpress LLC Spdb | 115088-06-7 | MFCD20229028 | 98.0% | 326.40 g·mol⁻¹ | C13H14N2O4S2 | 200 MG
SPDB is a glutathione-cleavable antibody-drug conjugate (ADC) linker provided for research use. It is designed to remain stable in circulation and be cleaved intracellularly by glutathione to release payloads, making it suitable for ADC synthesis, conjugation method development, and linker-cleavage studies.
- Glutathione-cleavable linker
- Stable in circulation, labile in target cells
- Suitable for ADC synthesis and linker-cleavage studies
- High purity (~98.0%) for reproducible results
- Available in multiple package sizes, including 200 mg
- Store sealed, away from moisture; recommended -20°C
Medchemexpress LLC Cyclopamine | 4449-51-8 | 411.62 | 200 MG
Cyclopamine is a steroidal alkaloid and a selective Smo inhibitor that acts as a Hedgehog (Hh) pathway antagonist, with an IC50 of 46 nM in Hh cell assays. It is used in research for its ability to suppress cell growth and inhibit Hh signaling.
- Hedgehog (Hh) pathway antagonist
- Selective Smo inhibitor
- Suppresses cell growth
- Inhibits Hh signaling through direct interaction with Smo
- Suitable for research and analytical applications
- Induces tumor remission in medulloblastoma models
- Blocks tumor formation in pancreatic adenocarcinoma cells
Apexbio Technology LLC CYC116 693228-63-6 200mg
CYC116 (CAS 693228-63-6) is a small-molecule inhibitor targeting Aurora kinases A and B critical serine/threonine kinases involved in mitotic processes such as centrosome maturation spindle assembly and cytokinesis CYC116 demonstrates potent inhibition with IC50 values of 44 nM for Aurora A and 19 nM for Aurora B and Ki values of 8 nM and 9 2 nM respectively In vitro studies indicate that CYC116 disrupts mitosis induces polyploidy and triggers cell death in cancer cells Preliminary in vivo assessments reveal oral bioavailability and antitumor activity CYC116 is currently under evaluation in phase I clinical trials as an anticancer agent
Apexbio Technology LLC Ranolazine 95635-55-5 200mg
Ranolazine (CAS 95635-55-5) is a small molecule that acts as an anti-ischemic agent by selectively inhibiting the late sodium current (INaL) in cardiac cells thereby reducing intracellular sodium accumulation and subsequent calcium overload via the Na /Ca2 exchanger This action mitigates adverse effects associated with ischemia-induced ionic imbalance Ranolazine has also been shown to shift ATP production from fatty acid oxidation toward glucose oxidation reflecting greater metabolic efficiency as glucose oxidation yields more ATP per mole of oxygen consumed Additionally it decreases oxygen consumption and suppresses fatty acid-driven ketogenesis in hepatic cells Ranolazine is widely utilized in research focused on myocardial energy metabolism and ischemic heart disease
Apexbio Technology LLC β-Naphthoflavone 6051-87-2 200mg
-Naphthoflavone (CAS 6051-87-2) also known as 5 6-benzoflavone is a small molecule that acts as a potent agonist of the aryl hydrocarbon receptor (AhR) Activation of AhR by -naphthoflavone upregulates the expression of metabolizing enzymes including multiple cytochrome P450 isoforms (CYPs) and uridine 5 -diphospho-glucuronosyltransferases (UGTs) This compound is widely utilized in biomedical research to investigate xenobiotic metabolism enzyme induction and the regulation of detoxification pathways Additionally it has been studied for its potential role in chemoprevention due to its modulatory effects on metabolic enzymes
Medchemexpress LLC Etravirine | 269055-15-4 | MFCD09837879 | 99.1% | C20H15BrN6O | 200 MG
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and a potent antiviral drug primarily used in the treatment of human immunodeficiency virus (HIV) type 1 infection. It is effective against various strains of HIV-1, including those resistant to other NNRTI treatments. This product is intended for research use only.
- Targets HIV-1 and HIV-2
- Inhibits non-nucleoside reverse transcriptase
- Effective against resistant HIV-1 strains
- Suitable for research applications
Apexbio Technology LLC Rotundine 483-14-7 200mg
Rotundine (CAS 483-14-7) also known as levo-tetrahydropalmatine (l-THP) is an isoquinoline alkaloid derived from plant species such as Stephania and Corydalis Pharmacologically l-THP acts as an antagonist at both D1 and D2 dopamine receptors exhibiting higher affinity for D1 (Ki 124 nM IC50 166 nM) than for D2 receptors (Ki 388 nM IC50 1 4 M) In vivo studies have shown that l-THP reduces spontaneous locomotor activity and operant responses in rodents in a dose-dependent manner Clinically approved in China l-THP is under investigation for its non-opioid analgesic properties and potential therapeutic utility in central nervous system-related disorders and substance use research
Medchemexpress LLC Pazufloxacin (mesylate) | 163680-77-1 | 100.0% | 1 ML
Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. It inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). This agent exhibits broad-spectrum antimicrobial activity with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. It is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia.
- Orally active fluoroquinolone antimicrobial agent
- Inhibits DNA gyrase
- Exhibits broad-spectrum antimicrobial activity against a variety of bacteria, including gram-positive, gram-negative, non-fermenting, Legionella spp., and anaerobic bacteria
- Indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia