Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,206 – 2,220 of 3,758 results

2,206

Apexbio Technology LLC AM095 1345614-59-6 200mg

AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies

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2,207

Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 10mM (in 1mL DMSO)

Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials

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2,208

Medchemexpress LLC Recombinant mouse interleukin-31 (IL-31) | >85.0% | 50 UG

Recombinant mouse interleukin-31 (IL-31) produced in HEK293 cells with a C-terminal His tag, supplied as a 0.22 μm filtered solution in PBS (pH 7.4). The protein is designed for biochemical and cell-based assays, including receptor binding and signaling studies; manufacturer provides activity, purity, and storage data.

Expressed in HEK293 mammalian cells.
C-terminal His tag for detection and purification.
Supplied in PBS (pH 7.4), 0.22 μm filtered.
>85.0% purity by reducing SDS-PAGE.
Approximate molecular weight 17.1 kDa (reducing SDS-PAGE).
Bioactivity: ED50 ≈ 2.916 μg/mL in receptor-binding ELISA.
Store long-term at -80°C; avoid repeated freeze-thaw.

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2,209

eMolecules EMOLECULES INC

5000489094 2-METHOXY-PYRIDINE-4-CARBAL 1G

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2,210

Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 100 MG

Dimidium bromide is a biochemical reagent suitable for use as a biological material or organic compound in life science research.

Biochemical reagent
Biological material
Organic compound
Suitable for life science related research

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2,211

Ambeed 4Bromobenzylamine

4-Bromobenzylamine, 3959-07-7, 98% GC

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2,212

Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 99.0% | C37H48N6O10S3 | 25 MG

Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. It is used for fluorescence imaging, enabling visualization of PD-L1 in tumors, site-specific modification of anti-PD-L1 antibodies, and RNA labeling. The probe can also be conjugated for imaging in atherosclerosis and breast cancer models.

Exhibits favorable click chemistry reactivity
Used for fluorescence imaging of PD-L1 in tumors
Facilitates site-specific modification of anti-PD-L1 antibodies
Applied in RNA labeling and imaging
Can be conjugated for imaging in atherosclerosis and breast cancer models
Detects ADP-ribosylation events via click chemistry
Conjugates to alkyne-functionalized TMV coat proteins (CuAAC)

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2,213

Medchemexpress LLC SRI 6409-94 | 127697-58-9 | 99.25% | 379.49 | 5 MG

SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. It serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.

Orally active compound.
Aids in the study of retinol's three-dimensional configuration and its effect on teratogenic activity.
Induces deformed offspring in a dose-dependent manner in virgin female outbred Syrian golden hamsters.
Leads to significant reductions in mean fetal body weight and the number of ossified skeletal districts in studies.
Purity of 99.25%.
Available in solid form with a light yellow to brown color.
Stable for 3 years at -20°C as a powder, and 2 years at 4°C as a powder.
In solvent, stable for 6 months at -80°C and 1 month at -20°C.

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2,214

Medchemexpress LLC Ipragliflozin L-Proline | 951382-34-6 | 99.9% | 519.58 | 200 MG

Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM, showing little to no potency for SGLT1/3/4/5/6. It is intended for research use only.

Potently and selectively inhibits human, rat, and mouse SGLT2.
Exhibits stability against intestinal glucosidases.
Shows good pharmacokinetic properties following oral dosing.
Dose-dependently increases urinary glucose excretion.
Reduces blood glucose and plasma insulin levels.
Improves glucose intolerance.

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2,215

Medchemexpress LLC Mal-amido-PEG9-acid | 2112731-43-6 | 99.5% | 250 MG

Mal-amido-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. These PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only and has not been fully validated for medical applications.

PEG-based linker
Used in synthesis of PROTACs
Facilitates selective degradation of target proteins
Utilizes ubiquitin-proteasome system
Contains two ligands connected by a linker

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2,216

Medchemexpress LLC Azido-PEG8-amine | 857891-82-8 | >99.9% | C18H38N4O8 | 100 MG

Azido-PEG8-amine is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group that enables its use as a click chemistry reagent for various bioconjugation strategies.

Functions as a click chemistry reagent
Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Utilized in the synthesis of PROTACs for targeted protein degradation

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2,217

Ambeed 3Aminopiperidine2 6dione

3-Aminopiperidine-2,6-dione, 2353-44-8, 98%

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2,218

Ambeed Dicyclohexyl 2 6 diisopropoxy

Dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine, 787618-22-8, 97%

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2,219

eMolecules 3-Quinolinecarboxylic acid, 6-(1,1-dimethylethyl)-4-hydroxy-, ethyl ester | | MFCD24843129 | 1g

WuXi ChemSupply | 3-Quinolinecarboxylic acid, 6-(1,1-dimethylethyl)-4-hydroxy-, ethyl ester | 1g | 599167578 | LN01319440 | 95.000 | | MFCD24843129 | 273.332 | C16H19NO3

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2,220

Medchemexpress LLC CR-1-31-B | 1352914-52-3 | >98.38% | 507.53 | 25 MG

CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. It effectively inhibits eIF4A by disrupting the interaction between eIF4A and RNA, thereby impeding protein synthesis initiation. This compound also interferes with the association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA and has been shown to induce apoptosis in neuroblastoma and gallbladder cancer cells.

Inhibits eIF4A by disrupting RNA interaction
Impairs protein synthesis initiation
Interferes with PfeIF4A association with RNA
Induces apoptosis in neuroblastoma and gallbladder cancer cells
Inhibits MUC1-C translation
Decreases MUC1-C abundance
Sensitizes gallbladder cancer cells to TRAIL-mediated apoptosis
Increases reverse glutamine metabolism in pancreatic cancer cells

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Quinolines and derivatives

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Apexbio Technology LLC AM095 1345614-59-6 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 10mM (in 1mL DMSO) Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Recombinant mouse interleukin-31 (IL-31) | >85.0% | 50 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 99.0% | C37H48N6O10S3 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SRI 6409-94 | 127697-58-9 | 99.25% | 379.49 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ipragliflozin L-Proline | 951382-34-6 | 99.9% | 519.58 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mal-amido-PEG9-acid | 2112731-43-6 | 99.5% | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Azido-PEG8-amine | 857891-82-8 | >99.9% | C18H38N4O8 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CR-1-31-B | 1352914-52-3 | >98.38% | 507.53 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More