Quinolines and derivatives

Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg

Cobicistat (GS-9350) is a selective inhibitor of cytochrome P450 3A enzyme (CYP3A) showing inhibitory activity with an IC50 ranging from 0 03 to 0 285 M in vitro It lacks intrinsic anti-HIV activity but serves primarily as a pharmacokinetic enhancer used in combination therapy to increase the systemic exposure of HIV-1 protease inhibitors such as atazanavir and darunavir Clinically cobicistat is administered orally to HIV-1-infected adults facilitating optimized dosing regimens Due to its selective CYP3A inhibitory mechanism cobicistat is employed in pharmacokinetic studies and drug-drug interaction investigations related to HIV treatments

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Apexbio Technology LLC Tempo 2564-83-2 200mg

Tempo (CAS 2564-83-2) is a stable nitroxide radical widely employed in biomedical research for its redox-active properties It facilitates the dismutation of superoxide radicals thereby modulating mitochondrial reactive oxygen species (ROS) levels and influencing cellular oxidative stress responses Tempo also serves as an oxidation catalyst particularly in the transformation of primary alcohols to aldehydes Studies indicate that Tempo exerts both antioxidant and mutagenic effects inducing DNA strand breaks and displaying cytotoxic and mutagenic activities in in vitro models such as murine lymphoma cells It is utilized for investigating oxidative stress redox regulation and chemical mutagenesis

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Apexbio Technology LLC Methscopolamine 155-41-9 200mg

Methscopolamine is a small-molecule antagonist targeting muscarinic acetylcholine receptors It is designed to inhibit these receptors thereby reducing acetylcholine-mediated signaling and regulating gastrointestinal secretions and motility Methscopolamine exerts its biological activity primarily through antagonism of muscarinic cholinergic receptors Based on these pharmacological properties methscopolamine holds research potential in studying muscarinic receptor-mediated physiological processes particularly gastrointestinal functions and secretory mechanisms and in experimental models evaluating peripheral cholinergic receptor contributions to gastrointestinal disorders

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Apexbio Technology LLC BMN-673 8R,9S 1207456-00-5 200mg

BMN-673 8R 9S (CAS 1207456-00-5) is an inactive stereoisomer of BMN-673 a potent poly(ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitor While BMN-673 demonstrates selective cytotoxicity toward tumor cells with deficiencies in BRCA1 BRCA2 or PTEN exploiting vulnerabilities in DNA repair pathways BMN-673 8R 9S lacks inhibitory activity This renders BMN-673 8R 9S a valuable negative control in studies investigating PARP inhibition mechanisms and differentiating on-target from off-target effects in cellular and in vivo models of DNA repair deficiency Its use supports rigorous evaluation of PARP1/2 inhibitor specificity in translational cancer research

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Medchemexpress LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.47% | 257.30 | 100 MG

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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• Utilized in the synthesis of PROTACs
• Contains two distinct ligands connected by a linker
• Exploits intracellular ubiquitin-proteasome system
• Selectively degrades target proteins

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TARGETMOL CHEMICALS INC MOZAVAPTAN 50MG

Also available in 10 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mozavaptan (OPC-31260) is a competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 uM and 14 nM respectively. purity: 99%

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Medchemexpress LLC Sulfo-LC-SPDP (sodium) | 169751-10-4 | MFCD00083162 | >90.0% | 527.57 | C18H22N3NaO8S3 | 25 MG

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Sulfo-LC-SPDP (sodium) is a water-soluble, cleavable heterobifunctional crosslinker that introduces a reducible disulfide linkage between amine and sulfhydryl groups. It is used as an ADC linker and for protein conjugation in research.

• Water-soluble, cleavable heterobifunctional linker.
• Introduces a reducible disulfide bond for controlled payload release.
• Contains an NHS ester for reaction with primary amines.
• Contains a pyridyldithiol group for reaction with thiols.
• Provided as the sodium salt for improved aqueous solubility.
• Available in small-mass quantities suitable for research-scale conjugation.

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AdipoGen Quinine HCl dihydrate

Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.

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Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 1g

Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials

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Medchemexpress LLC Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G

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Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G

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Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 10mM (in 1mL DMSO)

Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials

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