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Filtered Search Results
Medchemexpress LLC Aprepitant | 170729-80-3 | MFCD08277635 | 99.8% | 534.43 g/mol | C23H21F7N4O3 | 200 MG
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Aprepitant is a selective, high-affinity neurokinin 1 (NK1) receptor antagonist used in research to probe NK1-mediated signaling and substance P pathways. It is supplied as a white to off-white solid with high stated purity and is suitable for analytical, pharmacological, and GPCR studies.
- Selective neurokinin 1 receptor antagonist.
- High affinity with a reported Kd of ~86 pM.
- High purity suitable for analytical applications.
- White to off-white solid appearance.
- Available as powder and as DMSO solutions for convenience.
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TARGETMOL CHEMICALS INC PF-04979064 25MG
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Also available in 2 mg 5 mg 10 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nMrespectively). purity: 98%
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Medchemexpress LLC Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g/mol | C12H11N2NaO9S | 1 ML
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Sulfo-GMBS is a water-soluble, heterobifunctional cross-linker that links primary amines to sulfhydryl groups via a non-cleavable maleimide spacer. Supplied as a ready-to-use 10 mM solution in DMSO or as a solid, it is intended for protein and peptide conjugation, immobilization, and labeling in biochemical and assay workflows.
- Water-soluble amine-thiol cross-linker suitable for protein and peptide conjugation.
- Provides a short, non-cleavable spacer facilitating stable linkage between functional groups.
- Available as a 10 mM solution in DMSO or in solid form for flexible use.
- High purity (approximately 98.8%) supports reproducible conjugation reactions.
- Soluble in DMSO at 50 mg/mL (≈130.8 mM) for easy preparation of working solutions.
- Recommended storage: solid at -20°C sealed; in solvent at -80°C for extended stability.
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Apexbio Technology LLC LAQ824 (NVP-LAQ824,Dacinostat) 404951-53-7 200mg
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LAQ824 (NVP-LAQ824 Dacinostat CAS 404951-53-7) is a synthetic derivative of 4-aminomethylcinnamic hydroxamic acid that functions as a histone deacetylase (HDAC) inhibitor It exhibits potent HDAC inhibition with an IC50 of 0 03 M LAQ824 has demonstrated the ability to inhibit proliferation across a range of human cancer cell lines including colorectal (H1299 HCT116) breast (MDA435 SKBR-3 BT-474 MB-468) prostate (DU145 PC3) and non-small cell lung (A549) cancer models with IC50 values below 1 M Additionally it induces apoptosis in breast cancer cells and suppresses multiple myeloma cell growth in a time- and dose-dependent manner LAQ824 is widely utilized in cancer research to study epigenetic regulation and evaluate HDAC inhibitor-based therapeutic strategies
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Medchemexpress LLC Tacalcitol monohydrate | 93129-94-3 | MFCD13184757 | 99.9% | 434.65 g/mol | C27H46O4 | 10 MG
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Tacalcitol monohydrate is a vitamin D3 analog (1,24(R)-dihydroxyvitamin D3 monohydrate) used as a research reagent to modulate vitamin D receptor (VDR) signaling and calcium regulation. It is applied in studies of bone metabolism, skin disorders, inflammation, and oncology to probe VDR-mediated pathways.
- High purity (99.85%).
- Vitamin D3 analog that modulates vitamin D receptor activity.
- Applicable to in vitro and in vivo research on bone metabolism, skin disease, inflammation, and cancer.
- Supplied as a monohydrate solid for consistent dosing.
- Molecular weight 434.65 g/mol; formula C27H46O4.
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Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 200mg
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Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
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Apexbio Technology LLC Anastrozole 120511-73-1 200mg
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Anastrozole (CAS 120511-73-1) is a selective non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis by inhibiting the aromatase enzyme In in vitro assays using human placental aromatase anastrozole demonstrated an IC50 of 14 6 nM (0 0043 g/ml) Oral administration at 0 1 mg/kg completely inhibited ovulation in preclinical models and eliminated exogenous androgen-induced uterotrophic activity in juvenile rodents Additionally it has been shown to inhibit the conversion of 11-deoxycortisol to cortisol in guinea pig dog and bovine adrenal microsomes with IC50 values of 4 09 M 129 M and 11 9 M respectively Anastrozole is widely used in research to study estrogen-mediated pathways and endocrine modulation
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Medchemexpress LLC Bapta | 85233-19-8 | MFCD00036255 | 98.1% | 476.43 g/mol | C22H24N2O10 | 200 MG
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Bapta is a selective calcium (Ca2+) chelator used in biochemical and cellular research to buffer intracellular calcium and probe calcium-dependent signaling. It exhibits high selectivity over magnesium and can act as a calcium indicator; it has also been reported to inhibit phospholipase C independent of its chelating activity.
- Selective chelation of calcium with high magnesium selectivity.
- Functions as an intracellular calcium buffer and indicator.
- Useful for studying calcium-dependent signaling and calcium influx.
- Can inhibit phospholipase C independent of calcium chelation.
- Available in solid form and as ready-to-use solution formulations.
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TARGETMOL CHEMICALS INC ASTX660 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP. purity: 99%
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TARGETMOL CHEMICALS INC 3-Methyladenine 200MG
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Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kgamma (IC50 = 60 uM) and class III VPS34 (IC50 = 25 uM). 3-Methyladenine inhibits autophagy. Purity 99.51%
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eMolecules 6-BROMO-3-QUINOLINOL | 552330-94-6 | MFCD09260430 | 5g
AstaTech | 6-BROMO-3-QUINOLINOL | 5g | 213339936 | 83287 | 95.000 | 552330-94-6 | MFCD09260430 | 224.057 | C9H6BrNO
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Apexbio Technology LLC Sotalol 3930-20-9 200mg
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Sotalol (CAS 3930-20-9) is a non-selective adrenergic beta-receptor antagonist that inhibits both 1- and 2-adrenergic signaling pathways By blocking these receptors sotalol reduces sympathetic stimulation of the myocardium leading to decreased heart rate and myocardial contractility Furthermore it exhibits class III antiarrhythmic properties by prolonging cardiac action potential duration through inhibition of potassium channels Sotalol is utilized in biomedical research for investigating mechanisms underlying arrhythmogenesis and for evaluating therapeutic strategies in models of life-threatening ventricular and supraventricular arrhythmias
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Medchemexpress LLC 2(1H)-Quinolinone, 8-hydroxy- | 15450-76-7 | MFCD00216696 | 99.89% | 161.16 | 500 G
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8-Hydroxy-2(1H)-quinolinone is a biochemical reagent used in life science research. It is intended for research use only and not for medical applications.
- Can be used as a biological material or organic compound
- Suitable for life science related research
- Available in solid form
- White to off-white appearance
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Apexbio Technology LLC SCH 527123 473727-83-2 200mg
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SCH 527123 (CAS 473727-83-2) is a selective antagonist of chemokine receptor 2 (CXCR2) It inhibits CXCR2-mediated signaling pathways by reducing phosphorylation events within the NF- B MAPK and AKT signaling cascades In colorectal cancer cell lines SCH 527123 suppresses cell growth in a dose-dependent manner with reported IC50 values ranging from approximately 18 to 40 mol/L after a 72-hour treatment Elevated IL-8 expression in cell lines such as HCT116 and Caco2 correlates with decreased sensitivity to SCH 527123 This compound is utilized in research investigating CXCR2 signaling in inflammation and tumor growth
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Medchemexpress LLC Pravastatin sodium | 81131-70-6 | 99.4% | 200 MG
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Pravastatin sodium is an HMG-CoA reductase inhibitor that acts against sterol synthesis, with an IC50 of 5.6 μM. It belongs to the statin drug class and is utilized alongside diet, exercise, and weight-loss strategies to lower cholesterol and help prevent cardiovascular disease.
- Functions as an HMG-CoA reductase inhibitor.
- Targets sterol synthesis.
- Exhibits an IC50 of 5.6 μM for HMG-CoA reductase.
- Demonstrates inhibitory activity against cellular steroidogenesis in HepG2 cells with an IC50 of 1.37 μM.
- Inhibits cholesterol synthesis from [14C]-Acetate in isolated rat hepatocytes with an IC50 of 0.1 μM.
- Aids in lowering cholesterol.
- Contributes to the prevention of cardiovascular disease.
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