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Filtered Search Results
TARGETMOL CHEMICALS INC TD-198946 5MG
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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. TD-198946 a potent chondrogenic agent is a thienoindazole derivative. purity: 98%
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Apexbio Technology LLC Ridaforolimus (Deforolimus, MK-8669) 572924-54-0 200mg
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Ridaforolimus (Deforolimus MK-8669) (CAS 572924-54-0) is a small-molecule inhibitor targeting the mammalian target of rapamycin (mTOR) It is designed to inhibit mTOR activity thereby modulating mTOR-mediated signal transduction pathways Ridaforolimus exerts its biological activity primarily through inhibition of phosphorylation of downstream effectors such as S6 and 4E-BP1 In cell-based studies ridaforolimus demonstrates inhibitory activity with an IC50 value of approximately 0 2 nM in HT-1080 cells Based on these pharmacological properties ridaforolimus holds research potential in oncology therapeutics development
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Apexbio Technology LLC PNU-120596 501925-31-1 200mg
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PNU-120596 (CAS 501925-31-1) is a selective type II positive allosteric modulator (PAM) of the 7 neuronal nicotinic acetylcholine receptor (nAChR) It enhances 7nAChR-mediated responses significantly increasing Ca2 -dependent signaling at 3 M in cell-based assays with an EC50 of 216 nM in SH-EP1 cells In Xenopus oocytes PNU-120596 augments agonist-induced currents and prolongs current duration The compound displays specificity for 7nAChRs over other nAChR subtypes and potentiates acetylcholine responses in rat hippocampal interneurons It also increases CREB phosphorylation and improves recognition memory in rodent models supporting its utility in neuropharmacological research on cholinergic signaling
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Apexbio Technology LLC Mycophenolate mofetil hydrochloride 116680-01-4 200mg
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Mycophenolate mofetil hydrochloride (CAS 116680-01-4) is a small-molecule inhibitor targeting inosine monophosphate dehydrogenase (IMPDH) types I and II It is designed to selectively and reversibly inhibit IMPDH thereby modulating the de novo biosynthesis pathway of purine nucleotides Mycophenolate mofetil hydrochloride exerts its biological activity primarily through inhibition of IMPDH It demonstrates inhibitory activity with IC50 values of 39 nM for IMPDH type I and 27 nM for IMPDH type II Based on these pharmacological properties mycophenolate mofetil hydrochloride holds research potential in the study of immune processes organ transplant rejection mechanisms and autoimmune disease models
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Medchemexpress LLC GW 4064 | 278779-30-9 | 99.8% | 542.84 | 200 MG
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GW 4064 is a potent Farnesoid X Receptor (FXR) agonist with an EC50 of 65 nM.
- Reduces lipid accumulation in cells and represses oleic acid-induced CD36 protein levels, potentially preventing hepatic lipid accumulation.
- Suppresses weight gain and significantly represses diet-induced hepatic steatosis by lowering triglyceride and free fatty acid levels in the liver.
- Markedly reduces lipid transporter CD36 expression without affecting genes directly involved in lipogenesis.
- Attenuates hepatic inflammation.
- Leads to statistically significant reductions in serum activities of ALT, AST, LDH, and ALP, as well as reduced serum bile acid levels, suggesting hepatoprotective benefits.
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Ambeed Methyl 5bromo6oxo1 6dihydropyr
Methyl 5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylate, 178876-86-3, 98%
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Medchemexpress LLC Trilostane (Win 24540) | 13647-35-3 | 99.9% | C20H27NO3 | 200 MG
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Trilostane (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. It is a synthetic nonhormonal steroid that can be used for the research of breast cancer and prostate cancer.
- Competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor.
- Synthetic nonhormonal steroid.
- Used for the research of breast cancer and prostate cancer.
- Influences pregnenolone metabolism in adrenal cortex.
- Selectively inhibits pregnenolone converting to progesterone in the adrenal gland.
- Effectively controls pituitary-dependent hyperadrenocorticism (PDH) in dogs.
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Apexbio Technology LLC Meclofenoxate hydrochloride 3685-84-5 200mg
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Meclofenoxate hydrochloride (CAS 3685-84-5) is a synthetic compound formed from dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA) It is understood to influence cholinergic neurotransmission likely by increasing acetylcholine levels in the central nervous system through metabolic conversion of DMAE Preclinical studies have demonstrated that meclofenoxate hydrochloride enhances memory retention and supports various aspects of cognitive function This molecule is widely utilized in neurological and cognitive research to explore mechanisms underlying neuroprotection memory enhancement and age-related cognitive decline
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TARGETMOL CHEMICALS INC Monocrotaline 200MG
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Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Monocrotaline (Crotaline) is a pyrrolizidine alkaloid extracted from the seeds of the Crotalaria plant. Monocrotaline has certain cellular activity against HepG2 cells and can induce pulmonary hypertension in rodents. Purity 99.59%
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Medchemexpress LLC Phenmedipham | 13684-63-4 | 98.38% | 200 MG
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Phenmedipham is a carbamate herbicide. It is for research use only and not sold to patients.
- Carbamate herbicide
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Medchemexpress LLC Oltipraz | 64224-21-1 | 99.9% | 226.34 | C8H6N2S3 | 200MG
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Oltipraz is a research-grade small molecule that functions as an Nrf2 activator and HIF-1α inhibitor. Supplied as a brown-to-red solid powder for laboratory research, it is intended for use in mechanistic studies of oxidative stress, phase II detoxification, and hypoxia signaling; not for human consumption.
- High purity (99.9%).
- Molecular formula C8H6N2S3; molecular weight 226.34 g/mol.
- Available in multiple pack sizes including 200 mg vials.
- Solid, brown-to-red appearance suitable for standard laboratory handling.
- Storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (1 year) or -20°C (6 months).
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Medchemexpress LLC KNK437 | 218924-25-5 | 99.0% | 245.23 g/mol | C13H11NO4 | 200 MG
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KNK437 is a small-molecule heat shock protein (HSP) inhibitor that suppresses the induction of HSP105, HSP70, and HSP40. Provided as a light-yellow solid for research use, it is reported to have high purity and defined molecular weight, making it suitable for biochemical and cell-based studies of stress response and chaperone pathways.
- Inhibits induction of HSP105, HSP70, and HSP40.
- High purity suitable for biochemical and cell-based assays.
- Available in multiple pack sizes for experimental flexibility.
- Light-yellow solid form for standard laboratory handling.
- Stable when stored under recommended temperature conditions.
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Apexbio Technology LLC Zonisamide sodium 68291-98-5 200mg
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Zonisamide sodium (CAS 68291-98-5) is a synthetic 1 2-benzisoxazole derivative that was the first of its class developed for seizure modulation It exerts anticonvulsant activity primarily by blocking voltage-gated sodium channels and inhibiting T-type calcium channels thereby stabilizing neuronal membranes and reducing repetitive neuronal firing In biomedical research Zonisamide sodium is utilized for elucidating neuronal excitability investigating epilepsy pathophysiology and evaluating potential antiepileptic therapies in in vitro and in vivo models
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Medchemexpress LLC Dinaciclib 200mg | 779353-01-4 | 200MG
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Dinaciclib (SCH 727965) is a potent inhibitor of CDK with IC50s of 1 nM 1 nM 3 nM and 4 nM for CDK2 CDK5 CDK1 and CDK9 respectively[1
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Apexbio Technology LLC SR1078 1246525-60-9 200mg
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SR1078 (CAS 1246525-60-9) is a small-molecule agonist targeting retinoic acid receptor-related orphan receptors alpha and gamma (ROR and ROR ) It is designed to selectively activate these nuclear receptors thereby regulating transcriptional processes involved in metabolic homeostasis and immune responses SR1078 exerts its biological activity primarily through direct binding to the ligand-binding domains of ROR and ROR promoting receptor-mediated transcription In in vitro studies treatment of HepG2 cells with SR1078 enhances ROR-driven gene expression including upregulation of glucose-6-phosphatase and fibroblast growth factor 21 mRNA levels Based on these pharmacological properties SR1078 holds research potential in studying ROR / -mediated biological pathways and their physiological functions
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