Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC PP121 1092788-83-4 200mg
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PP121 (CAS 1092788-83-4) is a dual inhibitor of tyrosine kinases and phosphoinositide kinases It demonstrates potent inhibition of PI3K isoforms p110 (IC50 52 nM) p110 (1 4 M) p110 (1 1 M) p110 (150 nM) as well as DNA-PK (60 nM) and mTOR (10 nM) it does not affect serine/threonine kinases PP121 also targets multiple tyrosine kinases including Ab1 (21 nM) Hck (4 nM) Src (10 nM) VEGFR2 (55 nM) EGFR (550 nM) EphB4 (220 nM) and PDGFR ( 1 nM) In cell-based studies PP121 reverses v-Src mediated cell transformation restores actin stress fiber staining and inhibits mutant Ret kinase in thyroid tumor models with sub-nanomolar potency It is used to investigate kinase cross-talk and mechanisms underlying drug resistance
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Ambeed AMBEED
5000868511 DABIGATRAN ETEXILATE MESYL 1GR
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Selleck Chemical LLC Q-VD-Oph
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Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1 3 8 and 9 Q-VD-OPh can inhibits HIV infection
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eMolecules 1138331-79-9 | 1-(Cyclopropyloxy)-3,5-difluorobenzene | Synthonix - Stock | MFCD16996191 | 170.159 | C9H8F2O | 95.000 | Fc1cc(F)cc(OC2CC2)c1 | 1g | 495875274
1-(Cyclopropyloxy)-3,5-difluorobenzene | Synthonix - Stock | 1138331-79-9 | MFCD16996191 | 170.159 | C9H8F2O | 95.000 | Fc1cc(F)cc(OC2CC2)c1 | 1g | 495875274
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377303 CDK2-IN-31 5MG
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TARGETMOL CHEMICALS INC TPEN 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. Purity 99.79%
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TARGETMOL CHEMICALS INC Monocrotaline 200MG
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Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Monocrotaline (Crotaline) is a pyrrolizidine alkaloid extracted from the seeds of the Crotalaria plant. Monocrotaline has certain cellular activity against HepG2 cells and can induce pulmonary hypertension in rodents. Purity 99.59%
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Ambeed AMBEED
5000868456 1-QUINOLIN-2-YLETHANONE 1GR
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Medchemexpress LLC PVD-06 | 3032975-48-4 | 98.3% | 1074.13 | 25 MG
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PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). It induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. It can be used to further investigate PTPN2 in diseases such as leukemia and melanoma.
- Induces PTPN2 degradation
- Reduces PTPN2 protein levels
- Enhances phosphorylation of STAT1 in Jurkat cells
- Promotes T cell proliferation under CD3/CD28 stimulation
- Amplifies B16F10 cell growth inhibition in the presence of IFN-γ
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Medchemexpress LLC DBCO-amine (GMP) | 1255942-06-3 | MFCD22380759 | 276.33 | 200 MG
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DBCO-amine (GMP) is a high-grade click chemistry reagent featuring a DBCO group, enabling it to participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. This reagent is particularly utilized in the synthesis of antibody-drug conjugates (ADCs). It is a white to off-white solid.
- It is a click chemistry reagent.
- Contains a DBCO group.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- Used in the synthesis of antibody-drug conjugates.
- Appearance: solid.
- Color: white to off-white.
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Apexbio Technology LLC Coenzyme Q10 303-98-0 200mg
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Coenzyme Q10 (CAS 303-98-0) is a lipophilic benzoquinone involved in mitochondrial electron transport and cellular energy production It functions as an essential electron carrier within the electron transport chain facilitating ATP synthesis and exhibiting antioxidant properties by mitigating oxidative damage Coenzyme Q10 is frequently studied for its role in cellular metabolism bioenergetics and redox homeostasis Due to its involvement in mitochondrial function it is widely applied in research on metabolic disorders neurodegeneration and cardiovascular diseases The compound is soluble in organic solvents such as chloroform benzene and carbon tetrachloride For optimal stability it should be stored sealed in cool and dry conditions
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Ambeed AMBEED
5000868528 MAL-C6-AMINE TFA 1GR
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Apexbio Technology LLC SR-9243 1613028-81-1 200mg
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SR-9243 (CAS 1613028-81-1) is a small-molecule inverse agonist targeting liver X receptors (LXRs) nuclear transcription factors involved in metabolic regulation It is designed to induce LXR corepressor interactions thereby suppressing transcriptional activation of glycolytic and lipogenic enzyme genes SR-9243 exerts its biological activity primarily through inhibition of glycolysis- and lipid biosynthesis-associated gene expression In in vitro assays SR-9243 reduces cancer cell viability and induces apoptosis through caspase 3/7 activation in colorectal cancer cell lines Based on these pharmacological properties SR-9243 holds research potential in investigating metabolic reprogramming in cancer particularly in prostate colon and lung cancer models
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eMolecules 4965-36-0 | 7-Bromoquinoline | Ambeed | MFCD03695823 | 208.058 | C9H6BrN | 98.000 | Brc1ccc2cccnc2c1 | 500g | 595928416
7-Bromoquinoline | Ambeed | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 98.000 | Brc1ccc2cccnc2c1 | 500g | 595928416
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Medchemexpress LLC Dibenzocyclooctyne-amine | 1255942-06-3 | 276.33 | 50 MG
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DBCO-amine (GMP) is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a click chemistry reagent, containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. It is used in the synthesis of antibody-drug conjugates (ADCs).
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