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Filtered Search Results
Aobchem 5 6-Dimethoxy-pyridine-2-carboxylic acid | ≥95% | CAS 324028-89-9 | C8H9NO4 | 5g
5 6-Dimethoxy-pyridine-2-carboxylic acid | ≥95% | CAS 324028-89-9 | C8H9NO4 | 5g
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Medchemexpress LLC NLRP3-IN-11 | 2769040-91-5 | 344.8 | 200 MG
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NLRP3-IN-11 is an inhibitor of NLR family pyrin domain containing 3 (NLRP3) proteins. It demonstrates biological activity for NLRP3 with an IC50 value of less than 0.3 μM. This compound is under research for its potential use in addressing various inflammatory and degenerative diseases.
- Inhibits NLRP3 proteins.
- IC50 value for NLRP3: <0.3 μM.
- IC50 value in human PBMC NLRP3 assay: <0.3 μM.
- Potential research areas include NASH, atherosclerosis, other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and other autoinflammatory diseases.
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Medchemexpress LLC Ipatasertib | 1001264-89-6 | 458.00 | 200 MG
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Ipatasertib (GDC-0068) is an orally active, highly selective, and ATP-competitive pan-Akt inhibitor. It activates FoxO3a and NF-κB through Akt inhibition, leading to p53-independent activation of PUMA, and induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.
- Orally active and highly selective pan-Akt inhibitor
- ATP-competitive inhibition of Akt1, Akt2, and Akt3
- Synchronously activates FoxO3a and NF-κB
- Leads to p53-independent activation of PUMA
- Induces apoptosis in cancer cells
- Inhibits tumor growth in xenograft mouse models
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![eMolecules 898747-24-5 | 5-Bromo-1H-indazole-7-carboxylic acid methyl ester | J & W PharmLab LLC | MFCD08458991 | 255.071 | C9H7BrN2O2 | 96.000 | COC(=O)c1cc(Br)cc2cn[nH]c12 | 5g | 289352063](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000225216.jpg-250.jpg)
eMolecules 898747-24-5 | 5-Bromo-1H-indazole-7-carboxylic acid methyl ester | J & W PharmLab LLC | MFCD08458991 | 255.071 | C9H7BrN2O2 | 96.000 | COC(=O)c1cc(Br)cc2cn[nH]c12 | 5g | 289352063
5-Bromo-1H-indazole-7-carboxylic acid methyl ester | J & W PharmLab LLC | 898747-24-5 | MFCD08458991 | 255.071 | C9H7BrN2O2 | 96.000 | COC(=O)c1cc(Br)cc2cn[nH]c12 | 5g | 289352063
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Apexbio Technology LLC CUDC-907 1339928-25-4 200mg
CUDC-907 (CAS 1339928-25-4) is a dual inhibitor targeting histone deacetylases (HDACs 1 2 3 10) and class I phosphatidylinositol 3-kinases (PI3K) It exhibits nanomolar inhibitory activity against these enzymes blocking PI3K-mediated Akt signaling and increasing acetylation of histones and non-histone substrates (e g tubulin p53) In cancer cell models CUDC-907 induces G2-M phase arrest and reduces phosphorylation of downstream proteins such as p70S6 4EBP-1 MEK STAT3 and SRC Preclinical studies demonstrate its anti-tumor activity in lymphoma and NSCLC xenografts making it relevant for oncology research
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Medchemexpress LLC Piperidolate | 82-98-4 | 99.3% | 200 MG
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Piperidolate is an antimuscarinic that inhibits intestinal cramps induced by acetylcholine in rats and dogs. It is intended for research and analytical applications.
- Inhibits intestinal cramps
- Targets muscarinic acetylcholine receptors (mAChR)
- Relevant for neurological and neurodegenerative diseases
- Useful for GPCR/G protein and neuronal signaling research
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Medchemexpress LLC Closantel (sodium) | 61438-64-0 | 99.8% | 685.06 | 200 MG
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Closantel sodium is a halogenated salicylanilide with potent anti-parasitic activity. It acts as a potent and highly specific *Onchocerca volvulus* chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. This compound inhibits the *O. volvulus* L3 to L4 molt of developing organisms. It is highly specific for filarial family chitinases compared to those from protozoans and the human chitinase, human chitotriosidase.
- Potent anti-parasitic activity.
- Highly specific inhibitor of filarial family chitinases.
- Less effect on protozoans and human chitinase.
- For research use only.
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Apexbio Technology LLC GNF-5837 1033769-28-6 200mg
GNF-5837 (CAS 1033769-28-6) is a potent and selective pan-Trk inhibitor exhibiting inhibitory activity against TrkA and TrkB with IC50 values of 8 nM and 12 nM respectively In cellular assays GNF-5837 suppresses proliferation in TRKA/NGF-expressing Ba/F3 and RIE cells with IC50 values of 0 042 M and 0 017 M respectively The compound has also been shown to inhibit c-Kit and PDGFR in select cell models In vivo GNF-5837 demonstrated dose-dependent tumor inhibition in xenograft mouse models derived from TRKA/NGF-expressing RIE cells Its oral bioavailability and specificity make it a valuable tool for investigating TRK signaling in oncogenic processes and other disease models No clinical evaluation has been reported to date
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Medchemexpress LLC Chlorphenesin | 104-29-0 | MFCD00021990 | 99.8% | C9H11ClO3 | 200 MG
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Chlorphenesin is a reversible antigen-associated immunosuppressant with antibacterial and antifungal properties, commonly used in eye care cosmetics. It is intended for research use only.
- Reduces Akt pathway activity in human meibomian gland epithelial cells
- Induces rounding and atrophy of immortalized HMGECs
- Leads to reduced number of immortalized HMGECs
- Functions as an antibacterial agent
- Functions as an antifungal agent
- Utilized in eye care cosmetics
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Apexbio Technology LLC 17-Hydroxyprogesterone 68-96-2 200mg
17-Hydroxyprogesterone (68-96-2) is a small-molecule agonist targeting the progesterone receptor (PR) with partial agonist activity at glucocorticoid receptors (GR) and antagonist effects at mineralocorticoid receptors (MR) It modulates steroid hormone signaling pathways thereby influencing vascular tone and inflammation 17-Hydroxyprogesterone exerts its biological activity primarily through activation and modulation of steroid hormone receptors In animal models administration of 17-Hydroxyprogesterone demonstrates the ability to modulate vascular inflammation and uterine vascular tone Based on these pharmacological properties 17-Hydroxyprogesterone holds research potential in the screening of congenital adrenal hyperplasia and related metabolic syndromes as well as associations with respiratory distress syndrome and premature birth outcomes
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Medchemexpress LLC HPV16 E7 (86-93) (TFA) | 98.0% | 929.06 | 10 MG
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HPV16 E7 (86-93) TFA is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide, immunogenic in cervical carcinomas. It is for research use only. Precursor T cells specific for the peptide are able to differentiate into HPV-specific effector cells. Peptide-loaded autologous dendritic cells can stimulate a specific cytotoxic CD8+ T-cell response.
- Specific T cells are expandable upon in vitro stimulation with peptide-pulsed dendritic cells.
- Response against K562 cells pulsed with the peptide was significantly blocked by anti-HLA class I Ab w6/32.
- Peptide in IVS culture shows specific T cell expansion.
- The peptide can induce cytotoxic T lymphocyte (CTL) responses if loaded on antigen presenting HLA class I molecules.
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Medchemexpress LLC Tacalcitol monohydrate | 93129-94-3 | 99.9% | 434.65 | 5 MG
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Tacalcitol monohydrate promotes normal bone growth by regulating calcium ions. It also inhibits cancer cell proliferation and migration. This compound is suitable for research related to inflammation, cancer, and skin diseases.
- Promotes normal bone growth through calcium ion regulation.
- Inhibits cancer cell proliferation and migration.
- Inhibits the synthesis of IL-6 and IL-8 in nasal polyp fibroblast cultures in a dose-dependent manner.
- Induces cell differentiation in normal human keratinocytes.
- Inhibits the growth of normal and psoriatic human keratinocytes.
- Inhibits DNA synthesis in normal human keratinocytes.
- Strongly reduces the proliferation of human glioblastoma.
- Inhibits human glioblastoma migration.
- Significantly inhibits TPA-induced cutaneous inflammation and improves epidermal differentiation in hairless mice.
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Medchemexpress LLC Vinburnine | 4880-88-0 | 99.8% | 200 MG
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Vinburnine is a vinca alkaloid and a metabolite of vincamine, which acts as a vasodilator. It is intended for research use only.
- Allosteric modulator of muscarinic receptors M1-M4.
- Exhibits an anti-amnesia effect in a scopolamine-induced mouse amnesia model.
- Promotes erythrocyte glycolysis, increases erythrocyte ATP and 2,3-diphosphoglycerol content, and improves erythrocyte deformability and tissue oxygen delivery.
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Medchemexpress LLC Rivastigmine (ENA 713 free base) | 123441-03-2 | 99.9% | 250.34 | 200 MG
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Rivastigmine (ENA 713 free base) | 123441-03-2 | 99.9% | 250.34 | 200 MG
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Apexbio Technology LLC KNK437 218924-25-5 200mg
KNK437 (CAS 218924-25-5) is a benzylidene lactam small molecule that inhibits stress-induced synthesis of heat shock proteins (HSPs) HSPs function as molecular chaperones with increased expression under cellular stress and involvement in protein folding cancer and cardiovascular disease KNK437 suppresses the induction of various HSPs in human colon carcinoma cells (COLO 320DM) including after heat stress and arsenite exposure thereby preventing the development of thermotolerance in a dose-dependent manner In murine tumor models KNK437 reduces Hsp72 synthesis when administered prior to hyperthermia This compound is widely used to investigate HSP-mediated stress responses and mechanisms of thermotolerance in cancer research
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