Quinolines and derivatives
Medchemexpress LLC 7,4'-Dihydroxyflavone | 2196-14-7 | MFCD00017694 | 1 ML
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from *Glycyrrhiza uralensis*. It acts as an eotaxin/CCL11 inhibitor and a CBR1 inhibitor with an IC50 of 0.28 μM. This compound can consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production.
- Inhibits MUC5AC gene expression
- Reduces mucus production and secretion
- Regulates NF-κB, STAT6, and HDAC2 pathways
- Decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with an IC50 value of 1.4 μM
Medchemexpress LLC Methotrexate metabolite | 19741-14-1 | MFCD00075774 | 98.4% | 325.33 g/mol | C15H15N7O2 | 200 MG
Methotrexate metabolite (DAMPA) is the primary active metabolite of methotrexate, supplied as an analytical standard for laboratory research, pharmacokinetic, and metabolism studies. It is intended for use as a reference standard in analytical assays and for investigation of methotrexate metabolism and clearance.
- Active metabolite of methotrexate used as an analytical standard.
- Suitable for pharmacokinetic and metabolism research.
- Molecular formula C15H15N7O2.
- Molecular weight 325.33 g/mol.
- Purity 98.4% (HPLC).
- Supplied as a solid for laboratory use.
- Not for human or veterinary use.
Medchemexpress LLC Mal-amido-(CH2COOH)2 | 207613-14-7 | 99.2% | 284.22 g·mol-1 | C11H12N2O7 | 50 MG
Mal-amido-(CH2COOH)2 is a maleimidoethyl-containing intermediate used in the synthesis of hydrophilic antibody-drug conjugate (ADC) linkers for research applications. It is supplied as a solid with high purity and is formulated to dissolve in DMSO for downstream conjugation workflows.
- CAS number 207613-14-7.
- Purity 99.2%.
- Molecular formula C11H12N2O7.
- Molecular weight 284.22 g·mol-1.
- Appearance solid; soluble in DMSO with ultrasonic warming and heating to 60°C.
- Storage powder -20°C up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Intended for research use only; not for human use.
Medchemexpress LLC 3,5-Dicaffeoyl-epi-quinic acid | 879305-14-3 | 97.73% | 516.45 | 1 MG
3,5-Dicaffeoyl-epi-quinic acid is a compound that can be extracted from Chrysanthemum morifolium. It possesses antioxidant activities and is capable of scavenging DPPH radical and superoxide anion radical. Its IC50 values for scavenging DPPH radical and superoxide anion radical are 5.6 μg/mL and 2.9 μg/mL, respectively.
- Extracted from Chrysanthemum morifolium.
- Exhibits antioxidant activities.
- Scavenges DPPH radical with an IC50 of 5.6 μg/mL.
- Scavenges superoxide anion radical with an IC50 of 2.9 μg/mL.
Apexbio Technology LLC Fludarabine(Synonyms: Fludarabine Phosphate, Fludara, Fludarabinum, 2-Fluoro-ara-AMP, 9H-Purin-6-amine), 200mg, CAS: 21679-14-1.
Fludarabine (CAS 21679-14-1) is a purine analog prodrug that inhibits DNA synthesis Upon cellular uptake it undergoes phosphorylation to its active triphosphate form (F-ara-ATP) disrupting DNA replication through inhibition of critical enzymes such as DNA primase DNA ligase I ribonucleotide reductase and DNA polymerases and In human myeloma RPMI8226 cell assays fludarabine suppressed cell growth reduced Akt phosphorylation and lowered anti-apoptotic proteins XIAP and Survivin In vivo studies demonstrated marked tumor growth inhibition in RPMI8226 xenograft models Fludarabine serves as a tool in oncology research particularly leukemia and multiple myeloma-related studies
Ambeed OC614 2 3Butanedione 2 3di
(OC-6-14)-[[2,3-Butanedione 2,3-di(oximato-κN)](1-)][2,3-butanedione 2,3-di(oxime-κN)]dichlorocobalt, 23638-66-6, 98%
Ambeed OC614 2 3Butanedione 2 3di
(OC-6-14)-[[2,3-Butanedione 2,3-di(oximato-κN)](1-)][2,3-butanedione 2,3-di(oxime-κN)]dichlorocobalt, 23638-66-6, 98%
Ambeed OC614 2 3Butanedione 2 3di
(OC-6-14)-[[2,3-Butanedione 2,3-di(oximato-κN)](1-)][2,3-butanedione 2,3-di(oxime-κN)]dichlorocobalt, 23638-66-6, 98%
TARGETMOL CHEMICALS INC MOZAVAPTAN 50MG
Also available in 10 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mozavaptan (OPC-31260) is a competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 uM and 14 nM respectively. purity: 99%
TARGETMOL CHEMICALS INC AL 8697 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AL 8697 is a selective p38(alpha) MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38(beta) (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity. purity: 99%
TARGETMOL CHEMICALS INC RO 31-8220 MESYLATE 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-(alpha)/(beta)I/(beta)II/(gamma)/(epsilon) (IC50 5/24/14/27/24 nM) and also shows potent inhibition against MSK1 MAPKAP-K1b S6K1 and GSK3(beta). purity: 99%
Apexbio Technology LLC Anastrozole 120511-73-1 200mg
Anastrozole (CAS 120511-73-1) is a selective non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis by inhibiting the aromatase enzyme In in vitro assays using human placental aromatase anastrozole demonstrated an IC50 of 14 6 nM (0 0043 g/ml) Oral administration at 0 1 mg/kg completely inhibited ovulation in preclinical models and eliminated exogenous androgen-induced uterotrophic activity in juvenile rodents Additionally it has been shown to inhibit the conversion of 11-deoxycortisol to cortisol in guinea pig dog and bovine adrenal microsomes with IC50 values of 4 09 M 129 M and 11 9 M respectively Anastrozole is widely used in research to study estrogen-mediated pathways and endocrine modulation
Apexbio Technology LLC Golvatinib (E7050) 928037-13-2 200mg
Golvatinib (E7050 CAS 928037-13-2) is a small-molecule inhibitor targeting the tyrosine kinases c-Met and VEGFR-2 Golvatinib inhibits phosphorylation of c-Met in MKN45 gastric cancer cells and VEGFR-2 in human umbilical vein endothelial cells (HUVECs) with IC50 values of 14 nM and 16 nM respectively Additionally it suppresses proliferation of various tumor cells including MKN45 EBC-1 Hs746T and SNU-5 and inhibits tumor growth in xenograft models via reduction of c-Met and VEGFR-2-mediated pathways Golvatinib is utilized in cancer research to explore targeted antitumor efficacy related to angiogenesis and oncogenic signaling
Apexbio Technology LLC Vinpocetine 42971-09-5 200mg
Vinpocetine (CAS 42971-09-5) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE) exhibiting a Ki of 14 2 M for Ca2 -dependent PDE in vitro It acts as a non-competitive inhibitor effectively modulating intracellular cGMP levels in smooth muscle In rat aortic cytosolic preparations vinpocetine inhibits Ca2 -PDE activity significantly while demonstrating minimal inhibition of Ca2 -independent cGMP PDE and cAMP PDE (Ki values 1000 M) Additionally vinpocetine attenuates 5-HT-induced contractions in intact rat aorta with an EC50 of 1 M This compound is used in research to explore mechanisms of smooth muscle relaxation and PDE regulation
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