Carboximidamides
eMolecules 29553-70-6 | Medchem Express | 4-CPPC | 5mg | 789373664 | HY-123814 | 287.227 | C14H9NO6
Ambeed | 2-Amino-35-difluoropyridine | 250mg | 560592618 | A241098 | 732306-31-9 | MFCD03788760 | 130.098 | C5H4F2N2
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eMolecules Building Block Tool<|a>
eMolecules 108-19-0 | Biuret | Combi-Blocks | MFCD00007946 | 103.081 | C2H5N3O2 | 98.000 | NC(=O)NC(N)=O | 5g | 296394882
Biuret | Combi-Blocks | 108-19-0 | MFCD00007946 | 103.081 | C2H5N3O2 | 98.000 | NC(=O)NC(N)=O | 5g | 296394882
Matrix Scientific 1-METHYLGUANIDINE HYDROCHLOR-5
1-methylguanidine Hydrochloride Mf C2h8cln3 Mw 109.56 Cas 21770-81-0 Mdl MFCD00012576
![Medchemexpress LLC Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl] | 1353644-70-8 | 99.7% | 442.51 g/mol | C25H26N6O2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243817.png-250.jpg)
Medchemexpress LLC Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl] | 1353644-70-8 | 99.7% | 442.51 g/mol | C25H26N6O2 | 50 MG
Theliatinib is a potent, ATP-competitive, orally active, and highly selective epidermal growth factor receptor (EGFR) inhibitor provided for research use in preclinical biochemical and cell-based studies.
- Potent ATP-competitive EGFR inhibitor with low-nanomolar activity.
- High chemical purity (99.72%).
- Molecular weight 442.51 g/mol; formula C25H26N6O2.
- Soluble in DMSO (~1 mg/mL) with recommended warming and pH adjustment.
- Stable when stored under recommended powder and solution conditions.
- Suitable for studies of wild-type and mutant EGFR signaling.
Medchemexpress LLC (+)-Columbianetin | 3804-70-4 | 246.26 | 5 MG
(+)-Columbianetin is an active compound that functions as an inhibitor of JNK and ERK, and an activator of TGFβ signaling. It effectively mitigates UVA-induced cellular damage by reducing phosphorylation of JNK and ERK, decreasing MMP-1 production, and reversing collagen degradation. Additionally, it provides protection against UVB-induced harm to human keratinocytes.
- Inhibits JNK and ERK pathways.
- Activates TGFβ signaling.
- Reduces MMP-1 production.
- Reverses UVA-induced collagen degradation.
- Alleviates UVA-mediated inhibition of Smad2/3 phosphorylation.
- Regulates AP-1 and ASK1-MAPK signaling pathways.
- Inhibits ROS production.
- Protects human keratinocytes against UVB-induced damage.
- Applicable for research related to skin aging.
Medchemexpress LLC Clonidine hydrochloride | 4205-91-8 | MFCD00036705 | 99.9% | 500 MG
Clonidine hydrochloride is an agonist of α2-adrenoceptor and a potent antihypertensive agent. It is intended for research use only.
- Agonist of α2-adrenoceptor
- Potent antihypertensive agent
- Induces CGRP mRNA expression
- Increases NO level in endothelial cells
- Decreases body temperature in rats
- Suppresses dopamine efflux in the prefrontal cortex
Apexbio Technology LLC MRTX-1133(Synonyms: MRTX1133, MRTX 1133, Mirati-1133, KRAS G12D inhibitor MRTX1133), 5mg, CAS: 2621928-55-8.
MRTX-1133 (CAS 2621928-55-8) is a non-covalent alkyne-based inhibitor specifically targeting the KRAS G12D mutant protein It binds KRAS G12D with sub-picomolar affinity occupying the Switch II pocket and forming multiple intermolecular interactions Through these interactions MRTX-1133 disrupts SOS1-mediated guanine nucleotide exchange and prevents the assembly of KRAS-GTP/RAF1 signaling complexes thereby inhibiting downstream KRAS-driven signaling pathways MRTX-1133 is applied in cancer biology research to investigate tumor signaling and therapeutic strategies involving KRAS G12D mutations
Selleck Chemical LLC Creatine
Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN- receptors with JAK2 in an ATP-independent manner thereby inhibiting downstream pro-inflammatory gene expression
Apexbio Technology LLC MYK-461 1642288-47-8 10mM (in 1mL DMSO)
MYK-461 is a small-molecule inhibitor interacting directly with cardiac myosin heavy chain to modulate myocardial contraction It specifically reduces myocardial contractility through inhibition of cardiac myosin ATPase enzymatic activity thereby limiting myosin-mediated phosphate release without affecting ADP dissociation rates In rodent cardiomyocytes MYK-461 demonstrates dose-dependent reductions in fractional shortening and sarcomeric force generation without impacting calcium transient dynamics Its inhibitory potency against cardiac myosin ATPase surpasses that observed for skeletal muscle isoforms In preclinical hypertrophic cardiomyopathy mouse models MYK-461 administration attenuates cardiac contractile function facilitating investigations into myocardial contractility regulation and potential therapeutic strategies against hypertrophic cardiomyopathy
Medchemexpress LLC Clonidine hydrochloride | 4205-91-8 | 99.9% | 1 ML
Clonidine hydrochloride is an agonist of α2-adrenoceptor and a potent antihypertensive agent, primarily intended for research use. This specific product is a 10 mM solution in DMSO.
- Agonist of α2-adrenoceptor
- Potent antihypertensive agent
- For research use only
- High purity: 99.9%
- Induces CGRP mRNA expression in endothelial cells
- Increases NO level in endothelial cells
- Suppresses dopamine efflux in the prefrontal cortex
- Solution stable at -20°C for 1 month or -80°C for 6 months
![eMolecules 583050-70-8 | Ambeed | 27-Dioctylbenzo[b]benzo[45]thieno[23-d]thiophene | 100mg | 627733744 | A573973 | MFCD30541516 | 464.77 | C30H40S2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502454108.PNG-250.jpg)
eMolecules 583050-70-8 | Ambeed | 27-Dioctylbenzo[b]benzo[45]thieno[23-d]thiophene | 100mg | 627733744 | A573973 | MFCD30541516 | 464.77 | C30H40S2
Ambeed | 27-Dioctylbenzo[b]benzo[45]thieno[23-d]thiophene | 100mg | 627733744 | A573973 | 583050-70-8 | MFCD30541516 | 464.770 | C30H40S2
eMolecules 2978-11-2 | 4-Nitrobenzyl N,N'-diisopropylcarbamimidate | MFCD00042046 | 1g
Medchem Express | BGC-20-1531 (free base) | 5mg | 649421726 | HY-19849 | 736183-35-0 | 492.550 | C26H24N2O6S
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eMolecules 50-01-1 | Guanidine hydrochloride | Chem-Impex | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 10kg | 342450118
Guanidine hydrochloride | Chem-Impex | 50-01-1 | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 10kg | 342450118
eMolecules 19740-72-8 | Bicarbamic Acid Diisopropyl Ester | Toronto Research Chemicals | MFCD19443326 | 204.226 | C8H16N2O4CC(C)OC(=O)NNC(=O)OC(C)C | 250mg | 483384231
Bicarbamic Acid Diisopropyl Ester | Toronto Research Chemicals | 19740-72-8 | MFCD19443326 | 204.226 | C8H16N2O4CC(C)OC(=O)NNC(=O)OC(C)C | 250mg | 483384231
Medchemexpress LLC Isosinensetin | 17290-70-9 | MFCD21333406 | 99.9% | 372.37 | C20H20O7 | 10 MG
Isosinensetin is a naturally occurring flavonoid research compound used as an inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with reported activity against P-glycoprotein. It is provided as a high-purity reagent for biochemical and cell-based studies.
- High purity (99.9%) suitable for research applications.
- Molecular formula C20H20O7; molecular weight 372.37.
- Reported biological activities include PTP1B and HIV-1 protease inhibition and P-gp modulation.
- Recommended storage: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- Supplied as a 10 mg vial for small-scale laboratory research.