Carboximidamides
Medchemexpress LLC Creatine Kinase (CPK/CK), Bovine Heart | 9001-15-4 | 1 KU
Creatine Kinase (CPK/CK), Bovine Heart is a biological material or organic compound that can be used in life science research. It is for research use only and not sold to patients.
- Biological material
- Organic compound
- Used in life science research
eMolecules AstaTech / 2-(CYCLOPROPANECARBOXAMIDO)ACETIC ACID / 0.25g / 384830441 / F20136 / 95.000 / 64513-70-8 / MFCD01724840 / 143.142 / C6H9NO3
AstaTech / 2-(CYCLOPROPANECARBOXAMIDO)ACETIC ACID / 0.25g / 384830441 / F20136 / 95.000 / 64513-70-8 / MFCD01724840 / 143.142 / C6H9NO3
Medchemexpress LLC Creatine kinase MB (rCK-MB), recombinant human (CK-MB) | 9001-15-4 | 100 UG
Creatine Kinase MB (rCK-MB), Recombinant Human (CK-MB) is a biological material or organic compound that can be used in life science research. This product is intended for research use only.
- Appearance: liquid, colorless to light yellow.
- Enzyme activity: > 400 U/mL.
- Unit definition: one unit is defined as the amount of enzyme that catalyzes the transphosphorylation of one micromole of phosphate from creatine phosphate to ADP per minute at 37°C.
- Shipping with dry ice.
- Store under recommended conditions in the certificate of analysis.
Medchemexpress LLC Creatine (Standard) | 57-00-1 | 100.0% | 131.13 | 25 MG
Creatine (Standard) is the analytical standard of Creatine. Creatine is an endogenous amino acid derivative that plays an important role in cellular energy, especially in muscle and brain.
- Used as an analytical standard
- Suitable for qualitative research experiments
- Suitable for quantitative research experiments
- Suitable for methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC PXS-5120A | 2125955-70-4 | 98.1% | 100 MG
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. It exhibits high selectivity for LOXL2 over LOXL and effectively inhibits various forms of LOXL2 and LOXL3. In vivo studies demonstrate its rapid absorption and hydrolysis to the active free base, maintaining therapeutic plasma concentrations for extended periods.
- Potent, irreversible fluoroallylamine inhibitor of LOXL2/3
- Exhibits anti-fibrotic activity
- Over 300-fold selective for LOXL2 over LOXL
- Effectively inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, and collagen oxidation assay
- Inhibits recombinant human LOXL3 and recombinant human LOXL4
- Readily absorbed orally and rapidly hydrolyzed to the active free base
- Maintains plasma concentrations above LOXL2 IC50 for prolonged periods in mice
Chem-Impex International, Inc. Creatine, anhydrous | 57-00-1 | MFCD00004282 | 250G
Creatine, anhydrous, 57-00-1, MFCD00004282, 250G
Apexbio Technology LLC MYK-461 1642288-47-8 10mM (in 1mL DMSO)
MYK-461 is a small-molecule inhibitor interacting directly with cardiac myosin heavy chain to modulate myocardial contraction It specifically reduces myocardial contractility through inhibition of cardiac myosin ATPase enzymatic activity thereby limiting myosin-mediated phosphate release without affecting ADP dissociation rates In rodent cardiomyocytes MYK-461 demonstrates dose-dependent reductions in fractional shortening and sarcomeric force generation without impacting calcium transient dynamics Its inhibitory potency against cardiac myosin ATPase surpasses that observed for skeletal muscle isoforms In preclinical hypertrophic cardiomyopathy mouse models MYK-461 administration attenuates cardiac contractile function facilitating investigations into myocardial contractility regulation and potential therapeutic strategies against hypertrophic cardiomyopathy
Medchemexpress LLC ATX inhibitor 1 | 2225892-70-4 | 99.3% | 501.30 | 50 MG
ATX inhibitor 1 is a potent inhibitor of ATX (Autotaxin) with IC50 values of 1.23 nM (FS-3) and 2.18 nM (bis-pNPP). It is intended for research use only.
- Potent ATX inhibitor.
- IC50: 1.23 nM (FS-3) and 2.18 nM (bis-pNPP).
- Appearance: Solid, white to off-white.
- For research use only.
Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 25 G
Guanidine hydrochloride is a strong chaotrope and denaturant of proteins, widely used in biochemical research. It causes co-operative unfolding of the molten globule state at high concentrations and can refold acid-unfolded proteins at low concentrations.
- Induces co-operative unfolding of the molten globule state at concentrations greater than 1 M.
- Refolds acid-unfolded apomyoglobin and cytochrome c at low concentrations.
- Stabilizes the molten globule state.
- Does not affect disulfide bonds.
- Can cause efficient loss of the [PSI+] element from yeast cells at millimolar concentrations.
- Reduces Hsp104-mediated basal and acquired thermotolerance.
- Reduces Hsp104's ability to restore activity of thermally denatured luciferase.
- In vivo, significantly reduces the death rate of infant mice infected with coxsackievirus A16.
Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 50 G
Guanidine hydrochloride is a strong chaotrope and a strong denaturant of proteins, intended for research use only.
- Refolds acid-unfolded apomyoglobin and cytochrome c at low concentrations.
- Causes co-operative unfolding of the molten globule state at concentrations greater than 1 M.
- Does not affect ordered structure remaining due to disulfide bonds.
- Causes efficient loss of the normally stable [PSI+] element from yeast cells at millimolar concentrations.
- Reduces Hsp104-mediated basal and acquired thermotolerance.
- Reduces Hsp104's ability to restore activity of thermally denatured luciferase.
- Significantly reduced death rate of infant mice infected with coxsackievirus A16 in vivo.
Medchemexpress LLC Ask1-in-2 | 2541792-70-3 | 99.6% | 364.38 g·mol⁻¹ | C19H17FN6O | 5 MG
ASK1-IN-2 is a small-molecule, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 32.8 nM. It is supplied as a white to off-white solid and is available in multiple package sizes and as DMSO solutions for research use; preclinical studies report activity in dextran sulfate sodium (DSS)-induced ulcerative colitis models.
- Potent ASK1 inhibition (IC50 32.8 nM).
- Orally active compound demonstrated in preclinical models.
- Shown to improve DSS-induced ulcerative colitis in mice.
- Blocks ASK1-p38/JNK signaling and reduces inflammatory cytokines.
- High purity (99.6%) and solid, white to off-white physical form.
- Available as solid, solid + solvent, and solution formats for flexible use.
- Powder storage: -20°C for long-term stability; solvent storage guidelines provided.
Medchemexpress LLC Pentagamavunon-1 | 27060-70-4 | MFCD07958657 | 99.0% | C23H24O3 | 10MG
Pentagamavunon-1 (PGV-1) is a synthetic curcumin analog used in preclinical research as a cyclooxygenase (COX) inhibitor and apoptosis-inducing agent. It is employed in cellular and in vivo studies to investigate tumor suppression, reactive oxygen species (ROS) metabolism, and cell-cycle effects, and is provided as a stable solid with guidance for solvent preparation and storage.
- Curcumin analog with reported oral activity.
- Inhibits COX and modulates ROS metabolic enzymes.
- Induces apoptosis and M-phase (prometaphase) cell-cycle arrest.
- High purity suitable for research use (~99%).
- Soluble in DMSO for in vitro stock preparation.
- Stable with recommended low-temperature storage for long-term preservation.
Medchemexpress LLC Ccr4-351 | 2174938-70-4 | MFCD32701932 | 99.0% | 500.42 g/mol | C24H27Cl2N7O | 5 MG
CCR4-351 is a small-molecule, orally active CCR4 antagonist used for preclinical research. It shows potent and selective activity in cellular assays and has demonstrated antitumor efficacy in animal models. For research use only; consult the supplier datasheet and safety documents for handling, storage, and dosing guidance.
- Orally active and selective CCR4 antagonist.
- Demonstrated antitumor activity in vivo.
- Potent activity in cellular assays (low-nanomolar IC50 reported).
- High chemical purity suitable for research applications.
- Provided as a solid form for in vitro and in vivo studies.
- Refer to the product datasheet and safety documents for handling and dosing.
Medchemexpress LLC Vas 3947 | 869853-70-3 | MFCD06751667 | 99.6% | 310.33 | C14H10N6OS | 5 MG
VAS 3947 is a small-molecule NADPH oxidase (NOX) inhibitor used in research to inhibit NOX-dependent reactive oxygen species production. It is supplied as a white to off-white solid and is commonly used in studies of ROS signaling, platelet function, and apoptosis.
- High purity suitable for biological studies
- Solid, white to off-white appearance for easy handling
- Molecular formula C14H10N6OS and molecular weight 310.33
- Available in small research quantities such as 5 MG
- Recommended storage: powder -20°C for long-term stability
Medchemexpress LLC Melitracen hydrochloride | 10563-70-9 | MFCD00242905 | 99.8% | 327.89 | C21H26ClN | 100 MG
Melitracen hydrochloride | 10563-70-9 | MFCD00242905 | 99.8% | 327.89 | C21H26ClN | 100 MG