Carboximidamides
Medchemexpress LLC 1-tert-butyl N-(5R)-substituted triazole-4-carboxamide (BIIB091) | 2247614-80-6 | 99.9% | 542.64 g/mol | C28H34N10O2 | 5 MG
BIIB091 is a potent, selective, orally active, reversible Bruton tyrosine kinase (BTK) inhibitor supplied for laboratory research. It shows sub-nanomolar enzymatic potency and is provided as solid material or as a DMSO solution for in vitro and preclinical studies; refer to the manufacturer datasheet for safety, handling, and the certificate of analysis.
- Sub-nanomolar BTK potency (IC50 <0.5 nM).
- Reversible and highly selective BTK inhibition.
- Chemical formula C28H34N10O2; molecular weight 542.64 g/mol.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High purity (>99.8% by HPLC) suitable for research applications.
eMolecules AstaTech / 2-AMINO-4-(4-PYRIDINYL)-PYRIMIDINE / 0.25g / 721753963 / 31098 / 97.000 / 66521-70-8 / MFCD03305477 / 172.191 / C9H8N4
AstaTech / 2-AMINO-4-(4-PYRIDINYL)-PYRIMIDINE / 0.25g / 721753963 / 31098 / 97.000 / 66521-70-8 / MFCD03305477 / 172.191 / C9H8N4
TARGETMOL CHEMICALS INC N-p-Tosyl-GPR-pNA acetate 25MG
Also available in 1 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. N-(p-Tosyl)-GPR-pNA acetate is a colorimetric substrate for thrombin that can act as a measure of thrombin activity.
Medchemexpress LLC PDE12-IN-1 | 2259620-80-7 | 98.9% | 616.48 | C31H27BrFN5O3 | 10 MG
PDE12-IN-1 is a selective phosphodiesterase 12 (PDE12) inhibitor provided for laboratory research use. It shows potent enzyme inhibition and modulates 2′,5′-linked adenylate polymer levels in cellular assays. Intended for in vitro biochemical and cell-based studies; not for human or clinical use.
- Selective PDE12 inhibition with reported pIC50 ≈ 9.1.
- Suitable for biochemical and cellular assays.
- High purity: 98.9%.
- Available in small pack sizes for screening and optimization.
- Molecular formula C31H27BrFN5O3; molecular weight 616.48.
Cambridge Isotope Laboratories Clonidine (unlabeled) 100 mg/mL in methanol 1 2 mL
Clonidine (unlabeled) 100 mg/mL in methanol 1 2 mL
![Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233883.png-250.jpg)
Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 25 MG
Darigabat is an orally active, subtype-selective GABAA positive allosteric modulator used in neuroscience and pharmacology research. It has molecular formula C22H21FN4O3S and molecular weight 440.49 g/mol, and is supplied in small research quantities with high purity.
- Orally active GABAA positive allosteric modulator.
- Subtype-selective for α2/α3/α5 receptor subunits.
- High purity of 99.3% suitable for research applications.
- Molecular weight 440.49 g/mol and formula C22H21FN4O3S.
- Supplied in small-quantity packages for in vitro and in vivo studies.
Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 10 MG
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. It exhibits good CNS-agent like properties and clinical candidate potential. BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization. In vivo, BNC375 (0.003-10.0 mg/kg, administered orally) exhibits a Minimum Effective Dose (MED) of 0.03 mg/kg, achieving full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model. It has a plasma half-life (t1/2) of 1.2 hours.
- Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
- Exhibits good CNS-agent like properties.
- Clinical candidate potential.
- Significantly potentiates acetylcholine signal.
- Achieves full reversal of scopolamine-induced impairment in mouse T-maze model.
- Plasma half-life (t1/2) of 1.2 hours.
eMolecules Chem-Impex Guanidine hydrochloride 1kg 342450112 29913 0 000 50-01-1 MFCD00013026 95 530 CH6ClN3
Chem-Impex Guanidine hydrochloride 1kg 342450112 29913 0 000 50-01-1 MFCD00013026 95 530 CH6ClN3
Sigma Aldrich Fine Chemicals Biosciences GUANIDINE HYDROCHLORIDE 100MG
Sigma-Aldrich | Guanidine hydrochloride | 100 mg | 1302134-100MG | 50-01-1 | MW: 95.53
Medchemexpress LLC Ripk3-in-1 | 2361139-70-8 | 99.3% | C29H25FN4O4 | 10MG
RIPK3-IN-1 is a small-molecule, type II DFG-out inhibitor of receptor-interacting protein kinase 3 (RIPK3) intended for research use in biochemical and cellular studies. It exhibits potent biochemical activity and is supplied as a high-purity compound suitable for in vitro investigations into necroptosis and related signaling pathways.
- Potent RIPK3 inhibition, IC50 = 9.1 nM.
- High purity, 99.3% by supplier analysis.
- Chemical formula C29H25FN4O4 and molecular weight 512.53 g/mol.
- Suitable for biochemical and cellular assays targeting necroptosis pathways.
- Available in multiple sizes to support assay development and scale-up.
AdipoGen Diphenyliodonium PF6
Chemical. CAS 58109-40-3. Formula C12H10F6IP. MW 426.08. Synthetic. Catalyst for the photochemical polymerization of various monomers.
eMolecules Chem-Impex Guanidine hydrochloride 5kg 342450117 29914 0 000 50-01-1 MFCD00013026 95 530 CH6ClN3
Chem-Impex Guanidine hydrochloride 5kg 342450117 29914 0 000 50-01-1 MFCD00013026 95 530 CH6ClN3
Medchemexpress LLC 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1h)-yl)butyl)-3-methyl-1h-benzo[d]imidazol-2(3h)-one | 1121931-70-1 | 99.9% | C23H29N3O3 | 100 MG
CM398 is a highly selective, orally active sigma-2 receptor ligand. It exhibits a high sigma-1/sigma-2 selectivity ratio and shows notable affinity for dopamine and serotonin transporters. This compound has demonstrated promising anti-inflammatory analgesic effects in preclinical models of inflammatory pain.
- Highly selective sigma-2 receptor ligand
- Orally active
- High sigma-1/sigma-2 selectivity ratio
- Notable affinity for dopamine transporters
- Notable affinity for serotonin transporters
- Promising anti-inflammatory analgesic effects
Medchemexpress LLC AN0128 | 872044-70-7 | 98.95% | 400.06 | 50 MG
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. It is effective against various bacteria including *S. aureus*, *S. epidermidis*, *P. acnes*, and *B. subtilis*. This compound can be utilized in the research of periodontal disease and cutaneous diseases, demonstrating strong inhibition of pro-inflammatory cytokines *in vitro* and reduction of inflammatory infiltrate and bone loss *in vivo*.
- Boron-containing antibacterial and anti-inflammatory agent
- Effective against *S. aureus*, *S. epidermidis*, *P. acnes*, and *B. subtilis*
- Utilized for research on periodontal disease and cutaneous diseases
- Inhibits release of pro-inflammatory cytokines (TNF-α, IL-1β) in PBMCs
- Reduces inflammatory infiltrate and bone loss *in vivo*
- Increases bone area and bone volume in experimental periodontitis rat model
- Decreases bone loss and inflammation in experimental periodontitis rat model
Medchemexpress LLC Nortanshinone | 97399-70-7 | 1 MG
Nortanshinone is a pigment isolated from Dan-Shen, appearing as a brown to reddish-brown solid. It is classified under quinones and naphthalene quinones.
- For laboratory research
- Purity of 98.0%
- Molecular formula: C17H12O4
- Molecular weight: 280.27
- Isolated from plants such as Leguminosae and Labiatae