Carboximidamides
Apexbio Technology LLC MYK-461 1642288-47-8 10mM (in 1mL DMSO)
MYK-461 is a small-molecule inhibitor interacting directly with cardiac myosin heavy chain to modulate myocardial contraction It specifically reduces myocardial contractility through inhibition of cardiac myosin ATPase enzymatic activity thereby limiting myosin-mediated phosphate release without affecting ADP dissociation rates In rodent cardiomyocytes MYK-461 demonstrates dose-dependent reductions in fractional shortening and sarcomeric force generation without impacting calcium transient dynamics Its inhibitory potency against cardiac myosin ATPase surpasses that observed for skeletal muscle isoforms In preclinical hypertrophic cardiomyopathy mouse models MYK-461 administration attenuates cardiac contractile function facilitating investigations into myocardial contractility regulation and potential therapeutic strategies against hypertrophic cardiomyopathy
Sigma Aldrich Fine Chemicals Biosciences Nalpha Tosyl L lysne chlo500MG
Nalpha Tosyl L lysne chlo500MG
eMolecules 1187927-61-2 | N-(4-Chloro-phenyl)-guanidine oxalate | J & W PharmLab LLC | MFCD11506084 | 259.650 | C9H10ClN3O4 | 96.000 | OC(=O)C(O)=O.NC(=N)Nc1ccc(Cl)cc1 | 500mg | 553408292
N-(4-Chloro-phenyl)-guanidine oxalate | J & W PharmLab LLC | 1187927-61-2 | MFCD11506084 | 259.650 | C9H10ClN3O4 | 96.000 | OC(=O)C(O)=O.NC(=N)Nc1ccc(Cl)cc1 | 500mg | 553408292
Medchemexpress LLC Creatine kinase M-type (CKM), human recombinant, His-tagged | 9001-15-4 | >95.0% | 5 UG
Recombinant human creatine kinase M-type (CKM) is supplied as an N-His-tagged, full-length protein expressed in E. coli and provided as a lyophilized powder for research use only. The enzyme catalyzes reversible phosphate transfer between ATP and creatine and is suitable for biochemical activity assays, enzyme kinetics, and assay development.
- Full-length human CKM with N-terminal His tag.
- Expression system: E. coli.
- Approximate molecular weight 45 kDa.
- Purity greater than 95% by reducing SDS-PAGE.
- Reported specific activity ~3604 pmol/min/μg.
- Lyophilized formulation from HEPES buffer for stability.
- Store at -20°C before reconstitution; aliquot and freeze at -20°C or -80°C after reconstitution.
- Intended for research use only, not for clinical or diagnostic use.
Medchemexpress LLC Yuanhuacine (Gnidilatidin) | 60195-70-2 | 1 MG
Yuanhuacine (Gnidilatidin), a diterpene from *Daphne genkwa*, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. It can induce G2/M cell cycle arrest and exhibits broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent.
- Highly selective inhibitor for the BL2 subtype of TNBC.
- Induces G2/M cell cycle arrest.
- Exhibits broad anti-tumor activity.
- Acts as an orally active DNA damaging agent.
- Inhibits proliferation in various cancer cell lines including H1993, H358, H460, Calu-1, H1299, A549, UMUC3, and HCT116.
- Downregulates mTOR activation.
- Inhibits migration of H1993 cells.
- Upregulates p21 transcription and protein expression by regulating Sp1 protein stability.
Medchemexpress LLC Meloside A (Isovitexin 2''-O-glucoside) | 60767-80-8 | 5 MG
Meloside A, also known as Isovitexin 2''-O-glucoside, is a phenylpropanoid found in barley known for its antioxidant activity. This compound can inhibit cell apoptosis and reduce reactive oxygen species (ROS) production. It also demonstrates an ability to inhibit androgen receptor (AR) nuclear translocation and AR protein expression. Furthermore, Meloside A can decrease the levels of IL-6, TGF-β1, and DKK-1, making it a valuable tool for research in inflammation and endocrinology, including studies related to hair loss.
- Exhibits antioxidant activity
- Inhibits cell apoptosis and ROS production
- Inhibits androgen receptor (AR) nuclear translocation and expression
- Reduces IL-6, TGF-β1, and DKK-1 levels
- Useful for inflammation and endocrinology research
- Does not induce significant cytotoxicity in HDPCs (5-100 μg/mL, 24 h)
TARGETMOL CHEMICALS INC CLONIDINE 100MG
Also available in 50 mg and bulk. Please contact Fisher for quotes. Clonidine (Kapvay) is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent usually in combination with other agents. Despite wide-scale use for many years clonidine has not been linked definitively to either serum aminotransferase elevations or clinically apparent liver injury. purity: 99%
Medchemexpress LLC BIIB091 | 2247614-80-6 | 99.9% | 542.64 | 50 MG
BIIB091 is a potent, selective, orally active, and reversible BTK inhibitor, with an IC50 of <0.5 nM. It binds the BTK protein to sequester TYR-551 into an inactive conformation with excellent affinity. BIIB091 can be used for the research of multiple sclerosis.
- Potent and selective BTK inhibitor
- Orally active and reversible
- Excellent affinity
- Used for multiple sclerosis research
Medchemexpress LLC 3-O-Methylquercetin | 1486-70-0 | MFCD00210588 | 316.26 | 1 MG
3-O-Methylquercetin | 1486-70-0 | MFCD00210588 | 316.26 | 1 MG
Chem-Impex International, Inc. Tetramethylfluoroformamidiniun hexafluorophosphate | 164298-23-1 | MFCD02684443 | 25G
Tetramethylfluoroformamidiniun hexafluorophosphate, 164298-23-1, MFCD02684443, 25G
Medchemexpress LLC Isosinensetin | 17290-70-9 | 372.37 | 20 MG
Isosinensetin is a flavonoid compound and an inhibitor of HIV-1 protease and PTP1B (IC50: 2.61 μM; Ki: 0.92 μM). It inhibits P-glycoprotein (P-gp) in MDR1-MDCKII cells. Isosinensetin possesses anti-tumor, anti-viral, anti-inflammatory, and antioxidant effects. It is used in research for various diseases including cancer, inflammation, osteoporosis, and diabetes.
- Inhibits HIV-1 protease and PTP1B
- Inhibits P-glycoprotein
- Possesses anti-tumor, anti-viral, anti-inflammatory, and antioxidant effects
- Used in research for cancer, inflammation, osteoporosis, and diabetes
- Inhibits osteoclast formation and bone resorption
- Alleviates estrogen deficiency-induced osteoporosis
- Increases intracellular calcium ion concentration
- Stimulates GLP-1 secretion
- Inhibits erythrocyte hemolysis
Medchemexpress LLC Isosinensetin | 17290-70-9 | MFCD21333406 | 99.9% | 372.37 | C20H20O7 | 10 MG
Isosinensetin is a naturally occurring flavonoid research compound used as an inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with reported activity against P-glycoprotein. It is provided as a high-purity reagent for biochemical and cell-based studies.
- High purity (99.9%) suitable for research applications.
- Molecular formula C20H20O7; molecular weight 372.37.
- Reported biological activities include PTP1B and HIV-1 protease inhibition and P-gp modulation.
- Recommended storage: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- Supplied as a 10 mg vial for small-scale laboratory research.
![eMolecules 885-70-1 | 5,11-DIHYDROPYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE | AstaTech | MFCD00190169 | 211.224 | C12H9N3O | 95.000 | O=C1Nc2cccnc2Nc2ccccc12 | 1g | 449745713](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502443356.PNG-250.jpg)
eMolecules 885-70-1 | 5,11-DIHYDROPYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE | AstaTech | MFCD00190169 | 211.224 | C12H9N3O | 95.000 | O=C1Nc2cccnc2Nc2ccccc12 | 1g | 449745713
5,11-DIHYDROPYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE | AstaTech | 885-70-1 | MFCD00190169 | 211.224 | C12H9N3O | 95.000 | O=C1Nc2cccnc2Nc2ccccc12 | 1g | 449745713
Medchemexpress LLC β-cryptoxanthin ((3R)-β-cryptoxanthin) | 472-70-8 | MFCD09763658 | ≥99.0% | 552.9 g/mol | C40H56O | 1 MG
β-Cryptoxanthin is an oxygenated carotenoid (C40H56O) found in citrus fruits, red peppers, and pumpkin. It exhibits potent antioxidant activity and reported anti-stress effects, and is provided as a research-grade reagent for studies of antioxidant function, carotenoid metabolism, and nutritional biochemistry.
- Oxygenated carotenoid with antioxidant activity.
- Isolated from fruits and vegetables such as tangerines, red peppers, and pumpkin.
- Used in antioxidant assays and carotenoid biology studies.
- Available in small milligram pack sizes for research use.
- Molecular weight 552.9 g/mol; chemical formula C40H56O.