Carboximidamides
Medchemexpress LLC PIN1 inhibitor API-1 50mg | 680622-70-2 | 366.30 | C15H13F3N6O2 | 50 MG
PIN1 inhibitor API-1 is a selective peptidyl-prolyl cis-trans isomerase Pin1 inhibitor (IC50 = 72.3 nM) that binds the Pin1 PPIase domain and has been reported to up-regulate anticancer microRNA biogenesis and suppress hepatocellular carcinoma in preclinical models.
- Selective Pin1 inhibitor (IC50 72.3 nM).
- Molecular formula C15H13F3N6O2; molecular weight 366.30.
- Purity 99.63%.
- Appearance solid; color white to yellow.
- Soluble in DMSO (250 mg/mL); in vivo formulations ≥ 2.17 mg/mL in mixed solvents.
- Available in multiple package sizes including 50 MG.
Medchemexpress LLC PXS-5120A | 2125955-70-4 | 98.1% | 100 MG
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. It exhibits high selectivity for LOXL2 over LOXL and effectively inhibits various forms of LOXL2 and LOXL3. In vivo studies demonstrate its rapid absorption and hydrolysis to the active free base, maintaining therapeutic plasma concentrations for extended periods.
- Potent, irreversible fluoroallylamine inhibitor of LOXL2/3
- Exhibits anti-fibrotic activity
- Over 300-fold selective for LOXL2 over LOXL
- Effectively inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, and collagen oxidation assay
- Inhibits recombinant human LOXL3 and recombinant human LOXL4
- Readily absorbed orally and rapidly hydrolyzed to the active free base
- Maintains plasma concentrations above LOXL2 IC50 for prolonged periods in mice
Medchemexpress LLC Dryocrassin ABBA | 12777-70-7 | 820.83 | 5 MG
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative extracted from *Phyllopteris officinalis*. It demonstrates antitumor and antiviral activity, and induces apoptosis of human hepatocellular carcinoma cells via a mitochondrial pathway mediated by Caspase.
- Possesses antitumor activity
- Exhibits antiviral activity
- Induces apoptosis in human hepatocellular carcinoma cells via a mitochondrial pathway
- Inhibits S. aureus SrtA (sortase A) activity
eMolecules 3804-70-4 | Medchem Express | ()-Columbianetin | 5mg | 624169641 | HY-N0363 | MFCD02259437 | 246.262 | C14H14O4
Ambeed | 45-Dichloro-2-methoxybenzaldehyde | 1g | 600838744 | A368868 | 883532-73-8 | MFCD06246853 | 205.030 | C8H6Cl2O2
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Medchemexpress LLC Creatine kinase M-type/CKM protein, mouse (His) | >90.0% | 50UG
Recombinant mouse creatine kinase M-type (CKM) is supplied as a lyophilized, His-tagged protein expressed in E. coli for research use. CKM catalyzes reversible phosphate transfer between ATP and creatine phosphate and supports energy buffering in high-demand tissues. The material is provided with high purity and low endotoxin and is intended for biochemical assays, enzymology, and antibody validation. Store frozen and follow supplier reconstitution recommendations.
- High purity (>90%) as determined by reducing SDS-PAGE.
- Lyophilized formulation for long-term storage and convenient reconstitution.
- Expressed in E. coli with an N-terminal 6xHis tag to facilitate purification.
- Low endotoxin level (<1 EU/μg) suitable for sensitive assays.
- Molecular weight approximately 49.0 kDa, consistent with the CKM isoform.
- Recommended storage at -20°C; stable short term at 4°C after reconstitution.
eMolecules 2490400-70-7 | 3-((Difluoromethyl)sulfonyl)propan-1-amine hydrochloride | ChemScene209.640 | C4H10ClF2NO2S | 98.000 | Cl.NCCCS(=O)(=O)C(F)F | 100mg | 718356374
3-((Difluoromethyl)sulfonyl)propan-1-amine hydrochloride | ChemScene | 2490400-70-7209.640 | C4H10ClF2NO2S | 98.000 | Cl.NCCCS(=O)(=O)C(F)F | 100mg | 718356374
Medchemexpress LLC GDC-0276 50mg | 1494581-70-2 | 50 MG
Selective, orally active NaV1.7 inhibitor research compound intended for preclinical and clinical pharmacology studies. Demonstrates sub-nanomolar potency and favorable pharmacokinetics; supplied as a high-purity small-molecule solid for laboratory use.
- High purity (99.7%).
- Molecular weight 462.58.
- Chemical formula C24H31FN2O4S.
- Reported potency IC50 = 0.4 nM (NaV1.7).
- Supplied quantity 50 MG.
Medchemexpress LLC Guanidine, N-methyl-, hydrochloride (1:1) | 21770-81-0 | 109.56 | 500 MG
1-Methylguanidine monohydrochloride is provided as a white to off-white solid. It has been tested and complies with the given specifications. This product is intended for research use only and has not been fully validated for medical applications.
- White to off-white solid appearance
- Tested and complies with specifications
- Storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
Alkali Scientific Guanidine Hydrochloride, 500 G
Guanidine Hydrochloride, available in a 500g format, is a powerful chaotropic agent used extensively in molecular biology for protein denaturation and nucleic acid isolation. It disrupts protein structures by breaking hydrogen bonds and other stabilizing interactions, making it ideal for extracting nucleic acids or for use in protein unfolding studies. This reagent is commonly used in protocols for RNA, DNA, and protein purification, especially in the preparation of samples for further biochemical analysis. Its versatility extends to use in protein-protein interaction studies and structural analysis of biomolecules in research labs.
Medchemexpress LLC Creatine kinase MB (rCK-MB), recombinant human (CK-MB) | 9001-15-4 | 100 UG
Creatine Kinase MB (rCK-MB), Recombinant Human (CK-MB) is a biological material or organic compound that can be used in life science research. This product is intended for research use only.
- Appearance: liquid, colorless to light yellow.
- Enzyme activity: > 400 U/mL.
- Unit definition: one unit is defined as the amount of enzyme that catalyzes the transphosphorylation of one micromole of phosphate from creatine phosphate to ADP per minute at 37°C.
- Shipping with dry ice.
- Store under recommended conditions in the certificate of analysis.
eMolecules 62119-70-4 | 2-(Benzofuran-2-yl)acetic acid | ChemScene | MFCD00052742 | 176.171 | C10H8O3 | 97.000 | OC(=O)Cc1cc2ccccc2o1 | 100mg | 632281354
2-(Benzofuran-2-yl)acetic acid | ChemScene | 62119-70-4 | MFCD00052742 | 176.171 | C10H8O3 | 97.000 | OC(=O)Cc1cc2ccccc2o1 | 100mg | 632281354
STA Pharmaceutical ANA 2'-F U amidite | 5 g | CAS 1190089-70-3 | MDL MFCD15145421
ANA 2'-F U amidite is a Amidite reagent (Subcategory: ANA Series) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 1190089-70-3
- MDL: MFCD15145421
- InChIKey: HQHQPAYRJJMYQX-CPBIVIIKSA-N
- Molecular Weight: 748.789165161
- Molecular Formula: C39H46FN4O8P
- Purity: ≥98%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(NC(C=C5)=O)=O)F)OCCC#N)C(C)C)C
