Enamines
Medchemexpress LLC TO-1187 (TFA) | 98.4% | 795.72 | C36H36F3N9O9 | 10 MG
TO-1187 TFA is a selective PROTAC degrader that targets HDAC6 and recruits cereblon to promote ubiquitination and proteasomal degradation of HDAC6. Supplied as a trifluoroacetic acid salt in solid form, it is intended as a research tool for cellular and preclinical studies investigating HDAC6 biology and PROTAC-mediated target removal.
- Selective HDAC6 degrader with DC50 of 5.81 nM.
- Engages cereblon to induce ubiquitination and proteasomal degradation.
- High chemical purity (98.4%) suitable for biochemical and cellular assays.
- Provided as a solid TFA salt for stable handling and storage.
- Includes analytical documentation such as COA, H NMR, LCMS, and RP-HPLC.
- Storage recommended at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
Sigma Aldrich Fine Chemicals Biosciences Nicardipine hydrochloride United States Pharmacopeia (USP) Reference Standard | 54527-84-3 | MFCD00057327 | 200MG
Nicardipine hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 515.99 | 54527-84-3 | MFCD00057327 | 200MG
Apexbio Technology LLC Amlodipine Besylate 111470-99-6 10mM (in 1mL DMSO)
Amlodipine Besylate (CAS 111470-99-6) is a long-acting calcium channel blocker that reduces blood pressure primarily through inhibition of calcium ion influx via voltage-gated calcium channels Calcium channel modulation influences critical cellular signaling pathways In cortical neurons exposed to oxidative stress Amlodipine Besylate ( 5 M) preserves cellular viability by reducing oxidative damage enhancing pro-survival signals and suppressing apoptotic pathways It has also demonstrated proliferative effects on human epidermoid carcinoma (A431) cells Furthermore clinical studies indicate that Amlodipine Besylate decreases peripheral vascular resistance and myocardial oxygen demand in angina patients and effectively lowers arterial pressure in hypertensive feline models
Medchemexpress LLC 4-((((1-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-1h-1, | 98.4% | 795.72 | 5 MG
TO-1187 TFA is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It promotes the ubiquitination and degradation of HDAC6 and is used in the study of hematological malignancies and solid tumors. The compound is composed of an HDAC6 ligand, a CRBN ligase ligand, and a linker.
- Selective PROTAC degrader
- Promotes ubiquitination and degradation of HDAC6
- Applicable for studying hematological malignancies and solid tumors
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD16038299 | 99.2% | 665.66 g·mol⁻¹ | C27H26F3N7O6S2 | 5 MG
PF-562271 besylate is a small-molecule, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 used in research to study FAK pathway modulation. It is supplied as the besylate salt for laboratory use and has been evaluated in preclinical and clinical studies.
- Potent ATP-competitive inhibitor of FAK and Pyk2 (IC50 1.5 nM and 13 nM).
- Reversible mechanism suitable for biochemical and cellular assays.
- Supplied as besylate salt for improved stability and handling.
- High chemical purity (99.17%) for reproducible results.
- Molecular weight 665.66 g·mol⁻¹, molecular formula C27H26F3N7O6S2.
- Intended for research use only; not for human or veterinary use.
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 | C27H26F3N7O6S2 | 10 MG
PF-562271 besylate is the besylate salt of PF-562271, a potent ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 used in cancer research to probe signaling pathways, tumor growth, and cell adhesion. The compound is supplied as a high-purity solid for in vitro and in vivo studies.
- Potent inhibition of FAK and Pyk2 (FAK IC50 ~1.5 nM; Pyk2 IC50 ~13 nM).
- High reported purity (99.17%).
- Provided as a solid, off-white to light-yellow material suitable for handling and formulation.
- Demonstrated antiproliferative activity in multiple human cell lines.
- Used for in vitro and in vivo studies of tumor growth, signaling, and angiogenesis.
- Available in a 10 mg package for research use.
eMolecules 391624-46-7 | (9H-Fluoren-9-yl)Methyl (2-Aminoethyl)Carbamate Hydrochloride | AA Blocks LLC | MFCD00830741 | 318.800 | C17H19ClN2O2 | 0.000 | Cl.NCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 816441728
(9H-Fluoren-9-yl)Methyl (2-Aminoethyl)Carbamate Hydrochloride | AA Blocks LLC | 391624-46-7 | MFCD00830741 | 318.800 | C17H19ClN2O2 | 0.000 | Cl.NCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100g | 816441728
Sigma Aldrich Fine Chemicals Biosciences Amlodipine impurity G European Pharmacopoeia (EP) Reference Standard | 43067-01-2 | MFCD00194047 |
Amlodipine impurity G European Pharmacopoeia (EP) Reference Standard | Mol Wt: 335.78 | 43067-01-2 | MFCD00194047 |
Medchemexpress LLC Mirogabalin besylate | 1138245-21-2 | MFCD31631215 | 99.6% | 367.46 g·mol⁻¹ | C18H25NO5S | 1 ML
Mirogabalin besylate is the besylate salt of mirogabalin, a selective ligand for the α2δ subunit of voltage-gated calcium channels used in preclinical research. Supplied as a ready-to-use solution in DMSO, it is intended for in vitro and related laboratory applications. Refer to the safety data sheet for handling and storage instructions.
- 10 mM solution in DMSO, 1 mL vial.
- High purity (99.6%) as supplied.
- Molecular weight 367.46 g·mol⁻¹.
- Molecular formula C18H25NO5S.
- Recommended storage: in solvent -80°C (up to 6 months) or -20°C (up to 1 month); solid 4°C (sealed).
- Intended for research use only.
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.7 g/mol | C27H26F3N7O6S2 | 1 MG
PF-562271 besylate is an ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) used as a research tool in cell-signaling and oncology studies. It exhibits potent biochemical activity (FAK IC50 ≈ 1.5 nM; Pyk2 IC50 ≈ 13-14 nM), is supplied as the besylate salt, and is available at high purity for in vitro and in vivo research.
- Potent ATP-competitive, reversible inhibitor of FAK and Pyk2.
- Low nanomolar biochemical potency for target kinases.
- Provided as a besylate salt for improved stability and handling.
- High reported purity suitable for research applications.
- Used in cellular and animal model studies of tumor signaling pathways.
Medchemexpress LLC (S)-Nimodipine | 77940-93-3 | 99.9% | 418.44 | 50 MG
(S)-Nimodipine is an enantiomer of Nimodipine. Nimodipine is an orally active, well-tolerated, and light-sensitive dihydropyridine calcium antagonist. It can be used for the research of cerebrovascular disorders.
- Target: Calcium channel
- Pathway: Membrane transporter/ion channel; neuronal signaling
- Application: Research of cerebrovascular disorders