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Filtered Search Results
Medchemexpress LLC Benzoic acid, 4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro [5.5]undec-9-yl]methyl]phenoxy]-, hydrochloride (1:1) | 461023-63-2 | 99.9% | 614.17 | 25 MG
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Aplaviroc hydrochloride is a CCR5 antagonist derived from SDP, with IC50s ranging from 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL, and HIV-1MOKW. It is intended for research use only.
- Target: CCR5 antagonist
- Potency: Potent activity against wild-type R5 HIV-1 strains with IC50 values of 0.1 to 0.4 nM
- Mechanism: Suppresses infectivity and replication of HIV-1MDR variants at low concentrations (IC50 values of 0.4 to 0.6 nM)
- Binding Affinity: Binds to CCR5 with high affinity (Kd value of 2.9±1.0 nM)
- Inhibition: Potently blocks rgp120/sCD4 binding to CCR5 with an IC50 value of 2.7 nM
- In Vivo Efficacy: Suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice at a dosage of 60 mg/kg
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Tipiracil hydrochloride | 183204-72-0 | 99.9% | C9H12Cl2N4O2 | 100 MG
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Tipiracil hydrochloride is a thymidine phosphorylase inhibitor (TPI) used for cancer research. It exhibits antiangiogenic effects and inhibits the proliferation of endothelial cells. This compound is also a potent inhibitor of thymidine phosphorylase, an enzyme that degrades FTD. It is for research use only.
- Thymidine phosphorylase inhibitor (TPI)
- Exhibits antiangiogenic effects
- Inhibits the proliferation of endothelial cells
- Potent inhibitor of thymidine phosphorylase
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC W-7 (isomer hydrochloride) | 69762-85-2 | 99.7% | 377.33 | C16H22Cl2N2O2S | 50 MG
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W-7 (isomer hydrochloride) is a hydrochloride salt provided as a solid research reagent that acts as a calmodulin antagonist. It is used in biochemical and cellular studies to probe calmodulin-dependent signaling and enzyme activity; handle and store according to the supplier SDS for safety and stability.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Imeglimin (hydrochloride) | 775351-61-6 | 99.3% | 191.66 | 25 MG
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Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent that reduces reactive oxygen species (ROS) production, increases mitochondrial DNA, and improves mitochondrial function. This compound appears as a white to off-white solid.
- Oral glucose-lowering agent
- Reduces reactive oxygen species (ROS) production
- Increases mitochondrial DNA
- Improves mitochondrial function
- Soluble in H2O (≥ 50 mg/mL)
- Soluble in DMSO (25 mg/mL)
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Medchemexpress LLC Oxyfedrine hydrochloride | 16777-42-7 | MFCD01695148 | 99.9% | 349.85 g/mol | C19H24ClNO3 | 1 ML
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Oxyfedrine hydrochloride is a β-adrenoreceptor agonist supplied as a ready-to-use 10 mM solution in DMSO (1 mL) for research applications. The accurately prepared solution simplifies assay setup and reduces measurement variability. Storage and handling recommendations are provided to maintain product stability.
- Prepared 10 mM solution in DMSO, 1 mL.
- High purity (99.9% by HPLC).
- Suitable for in vitro assays and compound screening.
- Includes storage and stability guidance for solvent and solid forms.
- Molecular formula C19H24ClNO3; molecular weight 349.85 g/mol.
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Medchemexpress LLC Ravidasvir (hydrochloride) | 1303533-81-4 | MFCD32705191 | 99.9% | 835.82 | C42H52Cl2N8O6 | 5MG
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Ravidasvir hydrochloride is the hydrochloride salt of ravidasvir, a pan-genotypic hepatitis C virus (HCV) NS5A inhibitor supplied for research use. It is provided as solid vials in multiple sizes and as DMSO solutions for immediate assay use. Intended for in vitro research and assay development; not for human or clinical use.
- High purity suitable for analytical and biological research.
- Multiple solid vial sizes available, including small research quantities.
- Available as a ready-to-use 10 mM solution in DMSO for rapid testing.
- Molecular weight 835.82 and formula C42H52Cl2N8O6 for precise calculations.
- CAS number 1303533-81-4 for unambiguous identification.
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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | 99.5% | 576.13 g·mol⁻¹ | C28H42ClN7O4 | 10 MG
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EPZ004777 hydrochloride is a potent, selective inhibitor of the histone methyltransferase DOT1L used in epigenetic and leukemia research. It inhibits DOT1L with an IC50 of 0.4 nM, reduces H3K79 methylation in cells, and has been used to selectively kill MLL-rearranged leukemia cells. This material is supplied for research use only.
- Potent DOT1L inhibition (IC50 0.4 nM).
- Selective activity in biochemical and cellular assays.
- Reduces H3K79 methylation and downregulates leukemogenic gene expression.
- High chemical purity (99.5%).
- Available as solid and as DMSO solution for flexible use in experiments.
- CAS number 1380316-03-9; molecular weight 576.13 g·mol⁻¹.
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Medchemexpress LLC Ceftiofur hydrochloride | 103980-44-5 | 98.4% | C19H18ClN5O7S3 | 1 ML
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Ceftiofur hydrochloride is a potent cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs). It exerts bactericidal effects by inhibiting bacterial cell wall peptidoglycan synthesis, leading to cell lysis. Additionally, it possesses anti-inflammatory properties, inhibiting NF-κB and MAPKs, which reduces the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This compound has been shown to improve survival rates in endotoxemia models.
- Targets bacterial penicillin-binding proteins (PBPs)
- Inhibits bacterial cell wall peptidoglycan synthesis
- Induces bacterial cell lysis
- Reduces secretion of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6)
- Inhibits phosphorylation of ERK, JNK, and p38
- Blocks nuclear translocation of NF-κB p65
- Improves survival in endotoxemia models
- Cited in 4 scientific publications
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Medchemexpress LLC Nevanimibe hydrochloride | 133825-81-7 | 99.5% | 458.08 g/mol | C27H40ClN3O | 50 MG
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Nevanimibe hydrochloride is the hydrochloride salt of nevanimibe, an orally active and selective ACAT1 inhibitor supplied as a research-grade solid for in vitro and preclinical studies. The material is characterized by molecular identity and high purity suitable for biochemical and pharmacological assays.
- High purity suitable for analytical and biological assays.
- Hydrochloride salt form for improved stability and solubility in polar solvents.
- Well-characterized molecular identity and molecular weight for reproducible results.
- Available in small pack sizes appropriate for laboratory research.
- Intended for research use only; not for human or veterinary use.
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Medchemexpress LLC Verapamil hydrochloride | 152-11-4 | 99.8% | C27H39ClN2O4 | 100 MG
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Verapamil hydrochloride | 152-11-4 | 99.8% | C27H39ClN2O4 | 100 MG
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Medchemexpress LLC 7H-pyrrolo[2,3-d]pyrimidin-4-amine, N-butyl-N-ethyl-2,5,6-trimethyl-7-(trimethylphenyl) hydrochloride | 220953-69-5 | MFCD05664721 | 99.9% | 415.01 g/mol | C24H35ClN4 | 50 MG
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Antalarmin hydrochloride is a research-grade, non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist supplied as a white to light yellow solid for preclinical research. It is used to study stress-response pathways, CRH/CRF signaling, anxiety-like behavior, and inflammation models. The compound is provided at high purity and supplied in small mg-scale pack sizes suitable for laboratory use.
- Non-peptide CRHR1 antagonist used in stress and neuroendocrine research.
- High purity for reliable experimental results.
- Solid form, easy to weigh and formulate.
- Available in mg-scale pack sizes for preclinical studies.
- Includes datasheet, certificate of analysis, and safety data sheet documentation.
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Medchemexpress LLC Taltobulin hydrochloride | 228266-40-8 | 99.3% | 510.11 g/mol | C27H44ClN3O4 | 10 MG
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Taltobulin hydrochloride is the hydrochloride salt of taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin that functions as a potent tubulin (microtubule) inhibitor for preclinical cancer research and ADC payload development.
- Potent tubulin inhibitor that disrupts microtubule organization.
- Exhibits low-nanomolar in vitro activity (median IC50 ~1.7 nM).
- Demonstrated in vivo activity in mouse xenograft models (examples: 1.6 mg/kg i.v., 3 mg/kg p.o.).
- Supplied as a white to off-white solid for research use.
- Storage: solid at 4°C, sealed and protected from moisture; solutions stored at -80°C or -20°C for limited durations.
- High reported purity (~99.3%) suitable for biological studies.
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Medchemexpress LLC Pociredir hydrochloride | 2490676-19-0 | 99.9% | 439.87 | 10 MM/1 ML
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Pociredir hydrochloride, also known as FTX-6058, is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). It is utilized in research for select hemoglobinopathies like sickle cell disease and β-thalassemia by inducing HbF protein expression in cell and murine models.
- Potent and orally active inhibitor of EED
- Induces HbF protein expression in cell and murine models
- Used in research for select hemoglobinopathies, including sickle cell disease and β-thalassemia
- Inhibits PRC2 via binding to EED
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Medchemexpress LLC Ladostigil hydrochloride | 209394-18-3 | 99.9% | 308.80 g/mol | C16H21ClN2O2 | 50 MG
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Ladostigil hydrochloride is the hydrochloride salt of ladostigil, an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase. It exhibits neuroprotective, antioxidant, and anti-inflammatory properties and is used as a research reagent in studies of neurodegeneration, depression, and Alzheimer's disease.
- Dual cholinesterase and monoamine oxidase inhibitor
- Neuroprotective, antioxidant, and anti-inflammatory activity
- Hydrochloride salt for improved solubility
- Click-chemistry compatible (contains an alkyne group)
- High purity verified by RP-HPLC, suitable for research
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Medchemexpress LLC Etifoxine hydrochloride | 56776-32-0 | 99.8% | 337.24 | 10 MM 1 ML
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Etifoxine hydrochloride is a non-benzodiazepine GABAergic compound. It acts as a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. It has demonstrated anxiolytic and anticonvulsant properties in rodents.
- Acts as a positive allosteric modulator of GABAA receptors.
- Demonstrates anxiolytic properties.
- Demonstrates anticonvulsant properties.
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