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Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.7% | 522.68 | 100 MG
CXCR7 modulator 2 is a small molecule modulator of C-X-C Chemokine Receptor Type 7 (CXCR7) with a Ki of 13 nM. This compound exhibits potent CXCR7-binding affinity and β-arrestin activity, offering improved selectivity in GPCR panels and an enhanced therapeutic index in hERG patch-clamp assays. It demonstrates good aqueous solubility and is suitable for research applications.
- Potent CXCR7-binding affinity (Ki=13 nM)
- Beta-arrestin activity (EC50=11 nM)
- Improved selectivity in GPCR panel
- Improved therapeutic index in hERG patch-clamp assay
- Moderate to high in vitro turnover
- Good aqueous solubility
- Rapidly absorbed in vivo
- Reduces cardiac fibrosis in injury models
- Soluble in DMSO
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