Thioureas
eMolecules Chem-Impex Thiourea 2 5kg 342448902 00284 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
Chem-Impex Thiourea 2 5kg 342448902 00284 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
AdipoGen 7b-OH-cholesteryl-bishemisucci
Chemical. CAS 105449-93-2. Formula C35H54O8 . 2C2H7NO. MW 602.80 . 61.08. Synthetic Water-soluble derivatives of 7beta-hydroxycholesterol. Anticancer compound, inducing apoptosis in various solid tumor cell lines.
AdipoGen 4-Hydroxytamoxifen
Chemical. CAS 68392-35-8. Formula C26H29NO2. MW 387.51. 4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator SERM that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist-antagonist of the estrogen receptors ERalpha and ERbeta. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related ERR nuclear receptors beta and gamma. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2 amplitude, slowing relaxation and decreasing contractility. 4-Hydroxytamoxifen has also shown to be a potent inhibitor of the mitochondrial permeability transition MPT.
AdipoGen GSH-OEt
Chemical. CAS 92614-59-0. Formula C12H21N3O6S. MW 335.38. Synthetic. GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione GSH and glutathione ethyl ester GSH-OEt supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
AdipoGen 4-Hydroxytamoxifen
Chemical. CAS 68392-35-8. Formula C26H29NO2. MW 387.51. 4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator SERM that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist-antagonist of the estrogen receptors ERalpha and ERbeta. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related ERR nuclear receptors beta and gamma. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2 amplitude, slowing relaxation and decreasing contractility. 4-Hydroxytamoxifen has also shown to be a potent inhibitor of the mitochondrial permeability transition MPT.
AdipoGen MS-275
Chemical. CAS 209783-80-2. Formula C21H20N4O3. MW 376.4. HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.
AdipoGen Z-Leu-Leu-Glu-AMC
Chemical. CAS 348086-66-8. Formula C35H44N4O9. MW 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing PGPH caspase-like activity of the 20S proteasome. Excitation 380nm. Emission 460nm.
AdipoGen Q-VD-OPh
Chemical. CAS 1135695-98-5 anhydrous. Formula C26H25F2N3O6. MW 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl OPh group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
AdipoGen Z-Leu-Leu-Glu-AMC
Chemical. CAS 348086-66-8. Formula C35H44N4O9. MW 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing PGPH caspase-like activity of the 20S proteasome. Excitation 380nm. Emission 460nm.
AdipoGen CTPB
Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
eMolecules Chem-Impex Thiourea 1kg 386903162 30059 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
Chem-Impex Thiourea 1kg 386903162 30059 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
eMolecules 1-Hexyl-3-phenyl-2-thiourea | 15153-13-6 | MFCD00060425 | 1g
Oakwood Chemical | 1-Hexyl-3-phenyl-2-thiourea | 1g | 537677239 | 018708 | | 15153-13-6 | MFCD00060425 | 236.380 | C13H20N2S
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