Cinnamic acids and derivatives
TARGETMOL CHEMICALS INC TYRPHOSTIN AG1296 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 uM no activity to EGFR. purity: 99%
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 50 MG
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of β-barrel assembly machine A (BamA), making it impervious to efflux and the outer membrane permeability barrier. It is effective against both Gram-positive and Gram-negative bacteria, with an MIC of 12.5 μM for *Staphylococcus aureus* COL and 25 μM for *E. coli* JCM158.
- Inhibits β-barrel assembly machine A (BamA)
- Impervious to efflux and the outer membrane permeability barrier
- Exhibits strong activity against both Gram-positive and Gram-negative bacteria
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
TARGETMOL CHEMICALS INC BISDEMETHOXYCURCUMIN 50MG
Also available in 5 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis interacting with 1(alpha) 25-dihydroxy vitamin D3 to stimulate amyloid-(beta) clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300 suppressing the Wnt/(beta)-catenin pathway and inhibits LPS induction of iNOS expression [3]. purity: 99%
eMolecules 160434-49-1 | 3-Bromo-4-fluorocinnamic acid | Ambeed | MFCD00143095 | 245.047 | C9H6BrFO2 | 98.000 | OC(=O)\C=C\c1ccc(F)c(Br)c1 | 1g | 527443839
3-Bromo-4-fluorocinnamic acid | Ambeed | 160434-49-1 | MFCD00143095 | 245.047 | C9H6BrFO2 | 98.000 | OC(=O)\C=C\c1ccc(F)c(Br)c1 | 1g | 527443839
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g·mol⁻¹ | C10H6N2O | 1 ML
Tyrphostin 8 is a small-molecule inhibitor that targets tyrosine kinases and GTPases and also inhibits calcineurin phosphatase activity. It is supplied at high purity for use in biochemical and cellular assays; chemical identifiers include CAS 3785-90-8, formula C10H6N2O, and molecular weight 170.17 g·mol⁻¹.
eMolecules 56442-17-2 | 4-(4-Fluorobenzyloxy)benzaldehyde | Oakwood Chemical | MFCD00173650 | 230.238 | C14H11FO2 | 95.000 | Fc1ccc(COc2ccc(C=O)cc2)cc1 | 1g | 537669239
4-(4-Fluorobenzyloxy)benzaldehyde | Oakwood Chemical | 56442-17-2 | MFCD00173650 | 230.238 | C14H11FO2 | 95.000 | Fc1ccc(COc2ccc(C=O)cc2)cc1 | 1g | 537669239
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 50 MG
Tyrphostin 8 is a small-molecule research compound that acts as a weak epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and a more potent inhibitor of the serine/threonine phosphatase calcineurin. Supplied as a solid for laboratory research, it is intended for research use only.
- Small-molecule inhibitor of EGFR and calcineurin (EGFR IC50 560 μM; calcineurin IC50 21 μM).
- High purity: 98.0%.
- Chemical formula C10H6N2O; molecular weight 170.17 g/mol.
- CAS number 3785-90-8.
- Soluble in DMSO at ≥ 100 mg/mL.
- Appearance: light yellow to yellow solid.
- Storage: store at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical applications.
Medchemexpress LLC 4-Hydroxybenzylidenemalononitrile | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 25 MG
Tyrphostin 8 (4-hydroxybenzylidenemalononitrile, CAS 3785-90-8) is a small-molecule tyrosine kinase inhibitor reported to target EGFR, with additional activity against GTPases and the serine/threonine phosphatase calcineurin. Provided for research use in solid and DMSO solution formats, it has molecular formula C10H6N2O, molecular weight 170.17 g/mol, and listed purity 98.0%.
- Reported EGFR inhibitor (IC50 = 560 μM).
- Inhibits calcineurin phosphatase activity (IC50 = 21 μM).
- Also reported to inhibit GTPase activity.
- Supplied as solid and as 10 mM solution in DMSO for assay flexibility.
- Listed purity 98.0% suitable for biochemical research.
- Chemical formula C10H6N2O; molecular weight 170.17 g/mol.
TARGETMOL CHEMICALS INC TYRPHOSTIN AG 538 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Tyrphostin AG 538 is a chalcone compound an IGF-1 receptor kinase inhibitor (IC₅0 for 400 nM) that is potent cell-permeable reversible and competitive. purity: 99%
Medchemexpress LLC 2-Methoxycinnamic acid | 6099-03-2 | 178.18 | 50 G
2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase. It is intended for research use only and not sold to patients.
- Noncompetitive inhibitor of tyrosinase
- Purity of 99.94%
- Molecular weight: 178.18
- Chemical formula: C10H10O3
- Appearance: White to off-white solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 2 years, -20°C for 1 year
- Soluble in DMSO
Medchemexpress LLC Entacapone (Standard) | 130929-57-6 | 99.2% | C14H15N3O5 | 50 MG
Entacapone (Standard) is the analytical standard of Entacapone. It is a potent, reversible, peripherally acting, and orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits COMT from rat brain, erythrocytes, and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. It is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M), and PST-P (IC50s>50 μM).
- Used for research of Parkinson's disease
- Serves as an inhibitor of FTO demethylation with an IC50 of 3.5 μM, for research of metabolic disorders
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Intended for research and analytical applications
Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 100mg, CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells