Coumarins and derivatives
Medchemexpress LLC Coumarin 106 | 41175-45-5 | MFCD00041949 | >98.0% | 281.35 g/mol | C18H19NO2 | 25 MG
Coumarin 106 is a dipolar laser dye used as a research reagent with reported acetylcholinesterase and butyrylcholinesterase inhibitory activity. The compound has molecular formula C18H19NO2, molecular weight 281.35 g/mol, and CAS number 41175-45-5. It is commonly used in photophysical studies and enzymology research and is soluble in DMSO at concentrations ≥25 mg/mL.
![Medchemexpress LLC Methanesulfonamide, N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]- | 2791417-66-6 | 99.9% | 453.94 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000395426.png-250.jpg)
Medchemexpress LLC Methanesulfonamide, N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]- | 2791417-66-6 | 99.9% | 453.94 | 25 MG
MTX-531 is an oral drug that inhibits EGFR and PI3K, demonstrating anti-tumor effects. It also acts as a weak agonist of PPARγ, helping to alleviate hyperglycemia induced by PI3K inhibitors. This compound shows good tolerability in in vivo studies, without causing hyperglycemia, a common side effect of PI3K inhibitors.
- Inhibits EGFR with an IC50 of 14.7 nM, and PI3K with IC50 values ranging from 1.1 nM to 233 nM.
- Demonstrates anti-tumor effects, suppressing tumor proliferation and growth.
- Acts as a weak agonist of PPARγ with an IC50 of 2.5 μM, which helps to alleviate hyperglycemia.
- Indicates excellent tolerance in mice and the absence of hyperglycemia in vivo.
eMolecules 6-Fluoro-4-hydroxycoumarin | 1G | Ships from Wood Dale, IL | Chem-Impex | 1994-13-4 | MFCD03094006 | MW: 180.13
Chem-Impex | 6-Fluoro-4-hydroxycoumarin | 1G | 1994-13-4 | MFCD07383035 | MW:177.22
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eMolecules Building Block Tool
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | 97.0% | 220.18 g/mol | C11H8O5 | 500 MG
7-Methoxycoumarin-3-carboxylic acid is a coumarin-based fluorescent dye used to label peptides and small biomolecules. It exhibits ultraviolet excitation and blue emission, making it suitable for fluorescence assays, probe synthesis, and HPLC derivatization. The compound is supplied as a solid and should be handled and stored protected from light.
Medchemexpress LLC 3-aminochromen-2-one | 1635-31-0 | MFCD00016965 | 99.2% | 161.16 | C9H7NO2 | 500 MG
3-aminochromen-2-one is a coumarin-derived organic compound used primarily as a synthetic intermediate in coordination chemistry and organic synthesis. It is employed as a building block for the preparation of metal complexes and functionalized coumarin derivatives for research use. Chemical formula C9H7NO2; molecular weight 161.16.
- Used as an intermediate for synthesis of metal complexes.
- Can act as a ligand in coordination chemistry.
- Serves as a building block for fluorescent coumarin derivatives.
- Suitable for research-scale synthetic applications.
- Characterized by known molecular formula and molecular weight.
Sigma Aldrich Fine Chemicals Biosciences 7-Methoxycoumarin suitable for fluorescence, >=98.0% (TLC) | 531-59-9 | MFCD00006876 | 100MG
7-Methoxycoumarin suitable for fluorescence, >=98.0% (TLC) | Purity: >=98.0% (TLC) | Mol Wt: 176.17 | 531-59-9 | MFCD00006876 | 100MG
Chem-Impex International, Inc. 7-Amino-4-methylcoumarin | 26093-31-2 | MFCD00006868 | 5G
7-Amino-4-methylcoumarin, 26093-31-2, MFCD00006868, 5G
AdipoGen Coumarin 343
Chemical. CAS 55804-65-4. Formula C16H15NO4. Molecular Weight 285.29. Coumarin 343, also known as coumarin 519, is a laser dye that exists in neutral or anionic form, depending on the pH of the medium. This compund is not cell-permeable. Coumarin 343 has been used in many different applications that include solution dynamic probes, laser dyes and organic sensitizers in dye-sensitized solar cells. It is a good organic-dye photosensitizer for injecting electrons efficiently into the conduction band of semiconductors, such as TiO2, ZrO2, and ZnO. Coumarin 343 has been used in MALDI and FRET applications. Spectral data lambdamax 443nm EtOH, lambdaex 490nm, lambdalaser 512-520nm range.
Cayman Chemical 7-EthoxycoumarIn 250mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
Medchemexpress LLC Coumarin 106 | 41175-45-5 | MFCD00041949 | 6498.0% | 281.35 g/mol | C18H19NO2 | 10 MG
Coumarin 106 is a dipolar laser dye with fluorescent properties that also displays cholinesterase inhibitory activity. Supplied as a research-grade solid, it is used in fluorescence studies, dye-laser applications, and biochemical assays where cholinesterase modulation or fluorescent probes are required.
- Dipolar laser dye with fluorescent properties.
- Demonstrates AChE and BChE inhibition for biochemical studies.
- Molecular formula C18H19NO2; molecular weight 281.35 g/mol.
- Available in small research pack sizes suitable for analytical use.
- Supplied as a solid for standard laboratory storage and handling.
Medchemexpress LLC Coumarin (Standard) | 91-64-5 | 146.14 | 25 MG
Coumarin (Standard) is the analytical standard of Coumarin, intended for research and analytical applications. It is a potent and orally active anti-inflammatory agent, also exhibiting antinociceptive, antibacterial, antifungal, and anticancer activities. This compound serves as an analytical standard for qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Purity: 99.96%
- Appearance: Solid
- Color: White to off-white
- Structure classification: Phenylpropanoids, Coumarins
- Initial source: Plants (Compositae Ambrosia psilostachya DC., Umbelliferae), Microorganisms
Medchemexpress LLC 3-aminochromen-2-one | 1635-31-0 | 99.2% | 161.16 g·mol⁻¹ | C9H7NO2 | 100 MG
3-Aminocoumarin (3-aminochromen-2-one) is a small organic intermediate used in coordination chemistry and materials research. It serves as a ligand precursor for the synthesis of metal complexes and related coordination compounds. Supplied for research use, the compound is offered at high reported purity and in multiple laboratory package sizes.
- Intermediate for synthesis of metal complexes and coordination compounds.
- Acts as a ligand precursor in coordination chemistry.
- High purity suitable for research applications.
- Available in multiple small-scale package sizes for laboratory use.
- Molecular formula C9H7NO2; molecular weight 161.16 g·mol⁻¹.
Apexbio Technology LLC Coumarin 91-64-5 50mg
Coumarin (91-64-5) is a small-molecule inhibitor targeting cytochrome P450 isoforms It is designed to modulate enzyme activity thereby regulating metabolic pathways Coumarin exerts its biological activity primarily through inhibition of cytochrome P450 enzymes In in vitro studies coumarin demonstrates enzyme inhibitory activity with an IC50 range of approximately 0 5 to 10 M depending on the isoform and experimental system Based on these pharmacological properties coumarin holds research potential in anticoagulant anti-inflammatory and anticancer agent discovery
Medchemexpress LLC Linarin | 480-36-4 | 592.55 | 5 MG
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). It exhibits various activities such as anti-inflammatory, antioxidant, sleep aid, sedation, bone differentiation, anti-tumor, antibacterial, and antiviral properties. Linarin can be utilized in research for diseases like nervous system disorders, osteoporosis, and cancer.
- Orally active and selective inhibitor of acetylcholinesterase (AChE)
- Possesses anti-inflammatory activity
- Exhibits antioxidant properties
- Acts as a sleep aid and sedative
- Promotes bone differentiation
- Shows anti-tumor effects
- Demonstrates antibacterial activity
- Has antiviral properties
- Can be used to study nervous system diseases, osteoporosis, and cancer