Coumarins and derivatives
Ambeed 7-Amino-4-methylcoumarin | 26093-31-2 | MFCD00006868 | 1 g
7-Amino-4-methylcoumarin | Purity: 98% | Mol Wt: 175.18 | 26093-31-2 | MFCD00006868 | 1 g
eMolecules 20300-59-8 | 7-Methoxy-2-oxochromene-3-carboxylic acid | Combi-Blocks | MFCD00452770 | 220.180 | C11H8O5 | 98.000 | COc1ccc2cc(C(O)=O)c(=O)oc2c1 | 1g | 267167713
7-Methoxy-2-oxochromene-3-carboxylic acid | Combi-Blocks | 20300-59-8 | MFCD00452770 | 220.180 | C11H8O5 | 98.000 | COc1ccc2cc(C(O)=O)c(=O)oc2c1 | 1g | 267167713
Apexbio Technology LLC 6,7-Dihydroxycoumarin 305-01-1 10mM (in 1mL DMSO)
6 7-Dihydroxycoumarin (CAS 305-01-1) also known as esculetin is a naturally occurring coumarin derivative extracted from Aesculus hippocastanum Linn This compound exhibits notable antioxidant activity primarily by scavenging reactive oxygen species and inhibiting lipid peroxidation Additionally 6 7-dihydroxycoumarin has been studied for its modulatory effects on various cellular signaling pathways implicated in inflammation and apoptosis Its applications in biomedical research include investigations into oxidative stress inflammation and related disease models The compound is soluble in ethanol and dilute alkali and should be stored in a sealed cool and dry environment to preserve stability
Apexbio Technology LLC Coumarin 6 38215-36-0 50mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Apexbio Technology LLC Coumarin 6 38215-36-0 10mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 100mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Apexbio Technology LLC Palomid 529 914913-88-5 5mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Selleck Chemical LLC Dicoumarol-50mg
Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K.
Apexbio Technology LLC Dicoumarol 66-76-2 100mg
Dicoumarol (CAS 66-76-2) is a small molecule inhibitor targeting NAD(P)H quinone oxidoreductase 1 (NQO1) and pyruvate dehydrogenase kinase 1 (PDK1) exhibiting IC50 values of 0 37 M and 19 42 M respectively in vitro By inhibiting NQO1 Dicoumarol perturbs cellular redox homeostasis while its suppression of PDK1 modulates glycolytic flux and mitochondrial energy metabolism These actions make Dicoumarol a valuable tool for investigating tumor metabolism oxidative stress apoptosis and associated signaling pathways in biomedical research contexts
Apexbio Technology LLC HX 531 188844-34-0 5mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Apexbio Technology LLC Coumarin-3-carboxylic Acid 531-81-7 100mg
Coumarin-3-carboxylic Acid is a coumarin-derived small molecule commonly applied as an investigative tool in biomedical research focusing on signal pathway regulation It is utilized to modulate enzymatic activities and cellular signaling pathways Coumarin-3-carboxylic Acid s biological activity has been studied in the context of its lanthanide complexes for inhibitory effects on cell growth in K-562 cell lines In cell-based studies it demonstrates antiproliferative activity in K-562 cells Based on these pharmacological properties Coumarin-3-carboxylic Acid holds research potential in elucidating biological mechanisms underlying hematologic malignancies and related diseases
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 500mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Medchemexpress LLC Coumarin boronic aci 10mM 1mL
Coumarin boronic acid is a fluorescent probe The excitation and emission wavelengths of coumarin boronic acid are set to 360 nm and 430 nm respectively Coumarin boronic acid can be used to monitor the formation of amino acid and protein hydroxyl peroxides in real time which is beneficial for understanding the mechanisms of oxidative stress and protein post-translational modification[1]
Apexbio Technology LLC 3-Nitrocoumarin 28448-04-6 10mg
3-Nitrocoumarin (CAS 28448-04-6) is a selective inhibitor of phospholipase C- (PLC- ) an enzyme involved in cellular signal transduction through the hydrolysis of membrane phospholipids and subsequent generation of secondary messengers By suppressing PLC- catalytic activity 3-Nitrocoumarin disrupts related intracellular signaling pathways thereby enabling investigation of PLC- -mediated mechanisms in various physiological and pathological contexts This compound is widely utilized in studies focused on elucidating the roles of PLC- in disease models and fundamental biomedical research