Flavonoids
Medchemexpress LLC (-)-Epigallocatechin Gallate (Standard) | 989-51-5 | 98.05% | 458.37 | 25 MG
(-)-Epigallocatechin Gallate (Standard) is the analytical standard of (-)-Epigallocatechin Gallate, intended for research and analytical applications. It is a major polyphenol in green tea that can inhibit cell proliferation and induce cell apoptosis. It also inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity and possesses potent anticancer, antioxidant, and anti-inflammatory properties against various cancers like colorectal cancer, myeloid leukemia, and thyroid carcinoma.
- Analytical standard for research and analytical applications
- Inhibits cell proliferation and induces cell apoptosis
- Inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity
- Possesses potent anticancer, antioxidant, and anti-inflammatory properties
- Used as a reference standard in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
TARGETMOL CHEMICALS INC LUTEOLIN 7-O-GLUCURONIDE 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) possesses antioxidant activities. purity: 99%
![Medchemexpress LLC N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea (AST 487) | 630124-46-8 | MFCD11983171 | 98.9% | 529.56 g/mol | C26H30F3N7O2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286670.png-250.jpg)
Medchemexpress LLC N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea (AST 487) | 630124-46-8 | MFCD11983171 | 98.9% | 529.56 g/mol | C26H30F3N7O2 | 10 MG
AST-487 is a small-molecule RET kinase inhibitor provided for laboratory research. It inhibits RET autophosphorylation and downstream signaling (reported RET IC50 ≈ 880 nM) and shows activity against FLT3 (IC50 ≈ 520 nM) and several other kinases. The compound is supplied as a solid and as a DMSO solution and is intended for research use only.
- Inhibits RET kinase with reported IC50 ≈ 880 nM.
- Shows activity against FLT3 with reported IC50 ≈ 520 nM.
- Chemical formula C26H30F3N7O2; molecular weight ≈ 529.6 g/mol.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High supplier-reported purity (98.9% by supplier specification).
- Intended for research use only; not for clinical or human therapeutic use.
Medchemexpress LLC 4'-Methoxyflavone | 4143-74-2 | 99.63% | 252.26 | 25 MG
4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. It can inhibit cycle-dependent kinases, leading to cell cycle arrest, and regulate cell signaling pathways to influence cell proliferation and apoptosis. This compound can be used in cancer chemoprevention research.
- Flavonoid with antioxidant properties
- Anti-proliferative activity against cancer cells
- Inhibits cycle-dependent kinases
- Leads to cell cycle arrest
- Regulates cell signaling pathways to influence cell proliferation and apoptosis
- Used in cancer chemoprevention research
Medchemexpress LLC (±)-Catechin (rel-Cianidanol; rel-Catechuic acid) | 7295-85-4 | 99.5% | 500 MG
(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects.
- Induces adipocyte differentiation of human bone marrow mesenchymal stem cells (hBM-MSC)
- Increases adiponectin levels
- Increases PPARγ transcription
Medchemexpress LLC Catechin 7-O-β-D-glucopyranoside | 65597-47-9 | 452.41 | 1 MG
Catechin 7-O-β-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. It demonstrates antioxidant and anti-inflammatory activities, and mitigates mitochondrial dysfunction. This product can be utilized in research pertaining to intestinal inflammatory diseases.
- Exhibits antioxidant and anti-inflammatory activities
- Attenuates mitochondrial dysfunction
- Protective effect against Streptozotocin-induced cell damage
- Mild protective effect against LPS/D-GalN induced lethality in mice
- Prevents intestinal inflammatory damages in rat colitis models
Medchemexpress LLC Apigenin | 520-36-5 | 270.24 | 1 G
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor that inhibits cytochrome P450 2C9 in a purified enzyme system. It demonstrates dose- and time-dependent inhibition of cell proliferation in SGC-7901 cells.
- Competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Inhibits cytochrome P450 2C9 in a purified, reconstituted enzyme system.
- Demonstrates inhibition of cell proliferation in SGC-7901 cells in a dose- and time-dependent manner.
- Achieves growth inhibition rates of 38%, 71%, and 99% at 20, 40, and 80 μM, respectively, on the 7th day.
- Cloning efficiency in SGC-7901 cells treated with 80 μM for 24 and 48 hours was 9.8% and 5%, respectively.
Medchemexpress LLC (-)-Epigallocatechin Gallate | 989-51-5 | >98% | 458.37 | 1 G
(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol found in green tea. It inhibits cell proliferation and induces cell apoptosis, and inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. It possesses potent anticancer, antioxidant, and anti-inflammatory properties against various types of cancers, including colorectal cancer, myeloid leukemia, and thyroid carcinoma.
- Inhibits cell proliferation
- Induces cell apoptosis
- Inhibits glutamate dehydrogenase 1/2 activity
- Possesses anticancer, antioxidant, and anti-inflammatory properties
- Effective against various cancers such as colorectal cancer, myeloid leukemia, and thyroid carcinoma
TARGETMOL CHEMICALS INC AST 487 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AST 487 (NVP-AST 487) is a RET kinase inhibitor inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3. purity: 99%
American Radiolabeled Chemicals Inc DIHYDROXYFLAVONE 10ME
7,8-Dihydroxyflavone 10mg as solid, M.W. 254.24, Solvent: Solid, CAS # 38183-03-8, Tyrosine kinase receptor B (TrkB) agonist
AdipoGen Luteolin
Chemical. CAS 491-70-3. Formula C15H10O6. MW 286.2. Synthetic. Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase 15-LOX inhibitor. IL-6 production inhibitor. Fatty acid synthase FAS inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-gamma inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 PDE1-5. PKCepsilon and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator Phosphatidylinositol 3-kinase PI3K / Akt signaling inhibitor. p90 ribosomal S6 kinase RSK1/RSK2 kinase activity inhibitor.
TARGETMOL CHEMICALS INC PHILLYRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Phillyrin (Forsythin) is a novel AMPK activator has anti-obesity effects in nutritive obesity mice it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting it potentially contributes to the suppression of the activation of MAPK and NF-(kappa)B pathways it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells. purity: 99%
Medchemexpress LLC 4H-1-benzopyran-4-one, 2-(4-hydroxyphenyl)- | 4143-63-9 | MFCD00017687 | 97.0% | 238.24 g/mol | C15H10O3 | 25 MG
4′-Hydroxyflavone is a flavone-class small molecule for biochemical and pharmacological research. It is a reported aldose reductase inhibitor (IC50 = 12 μM) and is supplied as a purified solid suitable for in vitro assays, target validation, and screening studies. Typical analytical data include CAS 4143-63-9, molecular formula C15H10O3, and molecular weight 238.24 g/mol.
- Reported aldose reductase inhibitor (IC50 = 12 μM).
- High purity solid (97.0%).
- Characterized by CAS 4143-63-9 and molecular formula C15H10O3.
- Suitable for biochemical assays, target validation, and screening.
- Available in small research pack sizes for laboratory use.
Chem-Impex International, Inc. Quercetin | 117-39-5 | MFCD00006828 | 250G
Quercetin, 117-39-5, MFCD00006828, 250G