Flavonoids
Medchemexpress LLC Myricetin | 529-44-2 | C₁₅H₁₀O₈ | 100 MG
Myricetin is an analytical standard intended for research and analytical applications. This plant-derived flavonoid exhibits strong antioxidant, anticancer, antidiabetic, and anti-inflammatory activities. It is commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Common plant-derived flavonoid
- Strong antioxidant, anticancer, antidiabetic, and anti-inflammatory activities
- Reference standard for research and analytical applications
- Suitable for HPLC, GC, and MS experiments
Medchemexpress LLC Myricetin | 529-44-2 | C15H10O8 | 200 MG
Myricetin is a plant-derived flavonoid known for its strong antioxidant, anticancer, antidiabetic, and anti-inflammatory properties. It exhibits diverse cellular effects, including radical scavenging activity and the ability to modulate various signaling pathways, making it suitable for a wide range of research applications.
- Exhibits scavenging activity against various radicals and ions.
- Prevents cancer cell death by apoptosis through regulation of PI3K/Akt and MAPK signaling pathways.
- Displays antiphotoaging effects by quenching free radicals in the skin and suppressing UVB-induced COX-2 expression.
- Inhibits human Hsp70 with notable IC50 values.
- Causes inhibition of rabbit platelet aggregation induced by ADP, arachidonic acid, collagen, and PAF.
TARGETMOL CHEMICALS INC 5 7 4 -Trimethoxyflavone 10MG
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. 5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand. Purity 97.53%
Medchemexpress LLC AST 487 | 630124-46-8 | 98.9% | 529.56 | 25 MG
AST 487 is a potent RET kinase inhibitor with an IC50 of 880 nM, and also demonstrates inhibitory activity against Flt-3 with an IC50 of 520 nM. It effectively inhibits RET autophosphorylation and the activation of downstream effectors, making it suitable for studies on human thyroid cancer cell lines with activating RET mutations.
- Inhibits RET kinase (IC50 880 nM)
- Inhibits Flt-3 (IC50 520 nM)
- Targets other kinases including KDR, Flt-4, c-Kit, and c-Abl
- Potently inhibits growth of human thyroid cancer cell lines with activating RET mutations
- Functions as a novel, mutant FLT3 inhibitor
- Inhibits cellular proliferation in FLT3-ITD-Ba/F3 and D835Y-Ba/F3 cells (IC50 less than 5 nM)
Sigma Aldrich Fine Chemicals Biosciences Naringin >=95% (HPLC) | 10236-47-2 | MFCD00148888 | 100G
Naringin >=95% (HPLC) | Purity: >=95% (HPLC) | Mol Wt: 580.53 | 10236-47-2 | MFCD00148888 | 100G
Medchemexpress LLC Isovitexin 7-O-rutinoside | 212271-10-8 | 740.66 | 5 MG
Isovitexin 7-O-rutinoside is an anti-inflammatory agent that can be isolated from the Mongolian anti-hepatic plant Dianthus versicolor.
- Acts as an anti-inflammatory agent
TARGETMOL CHEMICALS INC APIGENIN-7-GLUCURONIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s 12.87 22.39 17.52 0.27 uM for MMP-3 MMP-8 MMP-9 MMP-13 respectively). purity: 99%
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | 10 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis* with anti-inflammatory activity. It protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. This compound inhibits PKM2 with an IC50 of 2.12 μM and also inhibits COX-2 and 5-LOX with IC50s of 27 μg/mL and 33 μg/mL, respectively. 7-Hydroxyflavone is orally active.
- Isolated from *Clerodendrum phlomidis*.
- Exhibits anti-inflammatory activity.
- Protects renal cells from nicotine-associated cytotoxicity.
- Inhibits PKM2, COX-2, and 5-LOX.
- Orally active.
- Inhibits EV71 3C protease and viral replication.
- Antioxidant properties: decreases MDA and ROS, increases SOD and GSH.
- Ameliorates ischemia/reperfusion injury and neuropathic pain.
- Improves hepatic steatosis and regulates blood glucose metabolism in NAFLD models.
Medchemexpress LLC Apigenin (Standard) | 520-36-5 | 270.24 | 100 MG
Apigenin (Standard) is the analytical standard of Apigenin, intended for research and analytical applications. It is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Reference standard supplied for assay
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 1 MG
Luteolin 7-O-glucuronide inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, and 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. It also inhibits NO production and mRNA expression of inflammatory mediators (COX-2, IL-6, IL-1β, and TNF-α) as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In a mouse sleep deprivation model, this compound improved depression-like and stress coping behaviors.
- Inhibits matrix metalloproteinases (MMPs) activities.
- Reduces NO production and inflammatory mediators.
- Inhibits NF-κB, p38, and JNK activation.
- Improves depression-like and stress coping behaviors.
- Suitable for in vitro and in vivo studies.