Linear 1 3-diarylpropanoids
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 5g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 1 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that also possesses antioxidant and anti-inflammatory activities. It can improve adipocyte functions and inhibits histamine release from rat peritoneal mast cells. This product is for research use only.
- Orally active anti-allergic agent
- Possesses antioxidant activities
- Exhibits anti-inflammatory activities
- Improves adipocyte functions
- Inhibits histamine release from rat peritoneal mast cells
Medchemexpress LLC (S)-(+)-1,2-propanediol | 4254-15-3 | 99.97% | C3H8O2 | 10 MM 1 ML
(S)-(+)-1,2-Propanediol is an endogenous metabolite. It can be used as an organic solvent and diluent in drug preparations. It can also be used as a chiral synthetic intermediate and a substrate for enzyme research. It is for research use only.
- Endogenous metabolite
- Organic solvent and diluent in drug preparations
- Chiral synthetic intermediate
- Substrate for enzyme research
- For research use only
![Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387556-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML
AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. It potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473. In vivo, it causes significant tumor growth inhibition in breast adenocarcinoma xenograft models.
- Allosteric AKT inhibitor.
- Potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM respectively.
- Inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway.
- Potently inhibits the phosphorylation of PRAS40.
- In vivo, potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473).
- Causes significant tumor growth inhibition in BT474c breast adenocarcinoma xenograft models when dosed at 200 mg/kg daily.
Medchemexpress LLC Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) | 4197-97-1 | 5 MG
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound isolated from Helichrysum Trilineatum. It facilitates AMP-activated protein kinase (AMPK) activation, which improves glucose tolerance, increases muscle fatty acid oxidation (FAO), and reduces fat accumulation in the liver and skeletal muscles of high-fat diet-induced (HFD) diabetic mice. These properties make Pinocembrin chalcone a promising compound for research related to gastric ulcers and diabetes.
- Antibacterial activity: Inhibits the growth of S. aureus in vitro.
- Metabolic regulation: Significantly increases the fatty acid oxidation rate and enhances the phosphorylation of AMPKα in C2C12 myotubes.
- Anti-diabetic effects: Improves glucose tolerance and reduces fat accumulation in the liver and muscles in HFD-induced diabetic mice.
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 10 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is for research use only.
- Regulates adipocyte differentiation through PPARγ activation.
- Modulates the expression and secretion of various adipokines.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory cytokines.
- Suitable for research use.
Medchemexpress LLC Brepocitinib P-Tosylate | 2140301-96-6 | 99.99% | 561.60 | 10 MG
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. It also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively. This product is intended for research use only.
- Potent dual JAK1 and TYK2 inhibitor
- Inhibits JAK2 and JAK3
- High purity of 99.99%
- Available in various quantities and forms
- Cited in multiple publications
- Undergoing various clinical trials
Medchemexpress LLC Isodecyl diphenyl phosphate | 29761-21-5 | MFCD00072254 | 99.0% | 390.45 | C22H31O4P | 10mg
Isodecyl diphenyl phosphate (IDPP) is a flame retardant IDPP has an ability to induce DNA damage and exertes S phase cell ratio-reducing effects in A549 cells[1]
Medchemexpress LLC Isodecyl diphenyl phosphate | 29761-21-5 | MFCD00072254 | 390.45 g/mol | C22H31O4P | 25mg
Isodecyl diphenyl phosphate (IDPP) is a flame retardant IDPP has an ability to induce DNA damage and exertes S phase cell ratio-reducing effects in A549 cells[1]
Medchemexpress LLC AKT inhibitor VIII | 612847-09-3 | MFCD23843802 | 99.0% | 551.64 g/mol | C34H29N7O | 100 MG
AKT inhibitor VIII is a cell-permeable, reversible allosteric inhibitor of Akt kinases used as a research reagent to probe PI3K/Akt signaling pathways. It is supplied as a light yellow solid for laboratory use.
- Allosteric, reversible Akt inhibitor.
- Isoform-selective activity with greater potency for Akt1 and Akt2.
- Reported IC50 values: Akt1 = 58 nM, Akt2 = 210 nM.
- Molecular formula C34H29N7O; molecular weight 551.64 g/mol.
- High reported purity (~99%).
- Supplied as a light yellow solid with recommended storage for powder at -20°C or 4°C depending on duration.
Medchemexpress LLC Dihydrochalcone 25g | 1083-30-3 | 210.27 g/mol | C15H14O | 25 G
Dihydrochalcone (CAS 1083-30-3) is a small-molecule research reagent supplied as a high-purity solid for in vitro and analytical applications.
- High purity ≥98%.
- Molecular formula C15H14O.
- Molecular weight 210.27 g/mol.
- Suitable for in vitro biochemical assays and as an analytical reference.
- Available in a 25 G pack for laboratory use.
Medchemexpress LLC Phosphine, diphenyl-1-pyrenyl- | 110231-30-6 | 95.0% | 386.42 | C28H19P | 50 MG
Diphenyl-1-pyrenylphosphine (DPPP) is a phosphine-based fluorogenic probe used to detect peroxides and lipid peroxidation in biological samples. It exhibits phototriggered aggregation-induced emission/aggregation-caused quenching behavior and is supplied as a solid reagent for research applications.
- Fluorogenic probe that reacts with peroxides to yield a fluorescent product.
- Sensitive detection of lipid peroxidation in cells and tissues.
- Exhibits phototriggered AIE/ACQ transition for enhanced fluorescence control.
- Off-white to light yellow solid, suitable for laboratory handling and storage.
- Store protected from light; stable under recommended cold storage conditions.