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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
TetOn h/m P53-sh-BSD shRNA lentiviral vector expressing with Blasticidin selection for studies in Human/Mouse Each vial provides a nominal titer of 2x10E6 transducing units TU Validated human P53 shRNA Lentivirus High-titer shRNA lentiviral particles specific for human tumor suppressor protein p53 (P53/TP53) The shRNA has been validated to meet or exceed 70% P53 knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
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m-PEG2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are molecules that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins. These molecules typically consist of two different ligands connected by a linker, where one ligand binds to an E3 ubiquitin ligase and the other binds to the target protein.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Utilizes the intracellular ubiquitin-proteasome system for selective degradation of target proteins
Intended for research use only
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m-PEG2-acid is a polyethylene glycol (PEG)-based PROTAC linker. It is primarily used in the synthesis of Proteolysis-Targeting Chimeras (PROTACs), which are molecules designed to exploit the intracellular ubiquitin-proteasome system. PROTACs achieve selective degradation of target proteins by linking them to an E3 ubiquitin ligase.
PEG-based PROTAC linker
Facilitates the synthesis of PROTACs
Molecular weight of 148.16
Chemical formula C6H12O4
Appears as a colorless to light yellow liquid
Density of 1.098 ±0.06 g/cm³
Storage for pure form: -20°C for 3 years, 4°C for 2 years
Storage in solvent: -80°C for 6 months, -20°C for 1 month
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Mouse IL-12 mRNA encodes a cytokine Interleukin-12 secreted by antigen-presenting cells such as dendritic cells macrophages and B cells It promotes the activation and proliferation of T cells and natural killer (NK) cells thus enhancing the body s immune response IL-12 induces the differentiation of T cells into Th1 cells thereby enhancing cell-mediated immunity and increasing the production of interferon- (IFN- ) crucial for antiviral and antitumor immune responses EZ Cap Mouse IL-12 mRNA (m1 ) is provided at 1 mg/mL encoding mouse IL-12 cytokine It contains a cap 1 structure generated through co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
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o-Vanillin (2-Vanillin) is a nature product could be extracted from Vanilla planifolia Pinus koraiensis fruit o-Vanillin is a potent antifungal agent o-Vanillin inhibits the growth of mycelia by disrupting the integrity of cell walls and cell membranes o-Vanillin inhibits Doxorubicin (HY-15142A)- and 4-hydroperoxycyclophosphamide-induced NF- B activation[1][2]
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