Phenols
Medchemexpress LLC Bromo-PEG1-C2-azide | 1144106-65-9 | 99.5% | C4H8BrN3O | 25MG
Bromo-PEG1-C2-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Utilizes the intracellular ubiquitin-proteasome system
Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59CIN8O8S2 | 100 MG
OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells.
- Exhibits DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3.
- Improved cell permeability.
- Shows antiproliferative effect in MV4;11 cells.
Medchemexpress LLC BSJ-02-162 | 2139329-47-6 | 98.1% | C43H49N11O7 | 1 ML
BSJ-02-162, also known as CDK4/6-IN-11, is a potent PROTAC CDK4/6 degrader. It is specifically designed with a thalidomide-based E3 ligase ligand, Palbociclib as a target protein ligand, and a PROTAC linker, making it suitable for targeted protein degradation studies.
- Potent PROTAC CDK4/6 degrader
- Composed of a thalidomide-based E3 ligase ligand
- Includes a target protein ligand
- Features a PROTAC linker
- Available in solid and solution formats
- Soluble in DMSO
- Store powder at -20°C for 3 years, 4°C for 2 years
- Store in solvent at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC BPK-21 | 2305052-77-9 | 99.6% | C23H16Cl2F3NO2 | 1 ML
BPK-21 is an active acrylamide that suppresses T cell activation by blocking the function of ERCC3. It specifically targets C342 in the helicase ERCC3, making it suitable for research applications related to T cell biology.
- Suppresses T cell activation
- Blocks ERCC3 function
- Specifically targets C342 in the helicase ERCC3
- Significantly impairs T cell activation at 20 μM
- Molecular weight: 466.28
- Appearance: Solid
- Color: White to off-white
eMolecules Chem-Impex Tetrahydroxydiborane 1kg 686069655 37128 0 000 13675-18-8 MFCD05663888 89 650 B2H4O4
Chem-Impex Tetrahydroxydiborane 1kg 686069655 37128 0 000 13675-18-8 MFCD05663888 89 650 B2H4O4
Cambridge Isotope Laboratories 2 2 3 3 4 4 5 6-OctaCB (unlabeled) 35 ug/mL in isooctane 1 mL
2 2 3 3 4 4 5 6-OctaCB (unlabeled) 35 ug/mL in isooctane 1 mL
Medchemexpress LLC Interleukin-21 protein, rat | >95.0% | 500 UG
Recombinant rat interleukin-21 supplied lyophilized for research use, expressed in E. coli and provided as a 500 μg vial. Intended for functional assays and binding studies; handle and store frozen for extended stability.
- Species: rat, recombinant protein
- Source: expressed in E. coli
- Formulation: lyophilized from PBS, pH 7.4
- Amount: 500 μg per vial
- Purity: >95.0% by reducing SDS-PAGE
- Molecular weight: ~16 kDa (reducing SDS-PAGE)
- Sequence range: P25-S146
- Recommended use: functional ELISA; reported ED50 12.16 ng/mL
- Storage: store at -20°C; freeze aliquots at -20°C or -80°C for long-term
Apexbio Technology LLC TUG-770 1402601-82-4 25mg
TUG-770 (CAS 1402601-82-4) is a potent agonist of the free fatty acid receptor 1 (FFA1/GPR40) a G protein-coupled receptor implicated in the enhancement of glucose-stimulated insulin secretion by pancreatic -cells TUG-770 demonstrates high affinity for FFA1 with an EC50 of 6 nM and over 150-fold selectivity compared to FFA4 as well as high selectivity over other receptors and transporters In INS-1E rat -cell lines TUG-770 promotes insulin secretion in the presence of elevated glucose Pharmacokinetic studies in mice indicate favorable oral absorption and bioavailability with dose-dependent reductions in blood glucose during glucose tolerance tests TUG-770 is a valuable tool for investigating FFA1-mediated pathways and glucose homeostasis in metabolic research
Medchemexpress LLC Ethanaminium, 2-(acetylthio)-N,N,N-trimethyl-, chloride (1:1) | 6050-81-3 | MFCD00038727 | 98.0% | 197.73 | C7H16ClNOS | 25 G
Acetylthiocholine chloride is a biochemical assay substrate commonly used to measure cholinesterase activity in enzymatic and diagnostic assays. It is supplied as a white to off-white solid, characterized by NMR, and accompanied by certificate of analysis information. Store sealed and protected from moisture; when prepared in solvent, follow recommended low-temperature storage for long-term stability.
- Used as a substrate for cholinesterase activity assays.
- Purity 98.0% (NMR).
- CAS number 6050-81-3.
- Molecular weight 197.73.
- White to off-white solid appearance.
- Available in multiple sizes, including 25 g.
- Store sealed, away from moisture; in solvent, -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC 3H-1,2-benzodithiol-3-one, 1,1-dioxide | 66304-01-6 | MFCD00132960 | 98.0% | 200.24 g·mol⁻¹ | C7H4O3S2 | 1 ML
Beaucage reagent is a small-molecule DNA-cleaving reagent used in nucleic acid research and oligonucleotide chemistry. It is commonly supplied as a 10 mM solution in DMSO for convenient handling in lab protocols. The material is documented at 98.0% purity and has a molecular weight of 200.24 g·mol⁻¹; follow supplier storage recommendations for optimal stability.
Medchemexpress LLC cis-1-Amino-9-octadecene | 112-90-3 | 90.0% | 267.49 | 500 G
cis-1-Amino-9-octadecene | 112-90-3 | 90.0% | 267.49 | 500 G
Medchemexpress LLC Norbornene | 498-66-8 | 99.9% | 94.16 | 25 G
Norbornene is a bicyclic compound. Its polymers can be utilized in tissue engineering and drug release systems.
- For research use only.
Medchemexpress LLC Methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate | 1802242-47-2 | MFCD00006432 | 25g
Enzalutamide impurity 4 is an impurity of Enzalutamide (HY-70002)
![Medchemexpress LLC Quinoxaline, 6-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl] | 746667-48-1 | 99.6% | 287.32 g·mol⁻¹ | C17H13N5 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000307903.png-250.jpg)
Medchemexpress LLC Quinoxaline, 6-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl] | 746667-48-1 | 99.6% | 287.32 g·mol⁻¹ | C17H13N5 | 1 ML
BIO-013077-01 is a pyrazole-based small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor family for in vitro research use. The compound has molecular formula C17H13N5 and molecular weight 287.32 g·mol⁻¹ and is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) or as solid aliquots.
- Potent inhibition of TGF-β receptor signaling in cellular assays.
- Available as a 10 mM solution in DMSO for immediate use.
- Also available as solid forms for long-term storage or bulk use.
- Well-characterized molecular properties (C17H13N5, 287.32 g·mol⁻¹).
- High purity suitable for research applications.
- For laboratory research use only; not for human or veterinary use.
Apexbio Technology LLC Adrenalone HCl 62-13-5 10mM (in 1mL DMSO)
Adrenalone hydrochloride (CAS 62-13-5) is a synthetic adrenergic agonist primarily targeting alpha-1 adrenergic receptors Through activation of these receptors Adrenalone induces vasoconstriction leading to reduced local blood flow This pharmacological property underpins its utility as a topical hemostatic agent in research settings where precise modulation of vascular tone is required Adrenalone is frequently employed to investigate adrenergic receptor signaling pathways and the physiological mechanisms underlying vascular constriction