Phenols
Medchemexpress LLC Irak4-in-21 | 2170694-04-7 | C28H28FN7O2 | 1 MG
IRAK4-IN-21 (compound 17) is an orally active, potent, and selective IRAK4 inhibitor. It effectively inhibits IL-23 production and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis.
- Potent and selective IRAK4 inhibitor with IC50 values of 5 nM for IRAK4 and 56 nM for TAK1.
- Effectively inhibits IL-23 production (IC50 = 0.17 μM).
- Decreases levels of IL-23, IL-6, and MIP-1β in various cell lines.
- Shows moderate efficacy in acute animal model studies for inhibition of IL-6 production.
Medchemexpress LLC Gol-NTR | 2968461-58-5 | C24H16F3N3O4 | 25 MG
Gol-NTR is a Golgi-targetable probe characterized by high selectivity and sensitivity. It is activated by Nitroreductase (NTR) and is capable of visualizing acute lung injury (ALI) and its repair function. The probe has a low detection limit of 54.8 ng/mL. It is suitable for research aimed at monitoring and assessing the response to sepsis-induced ALI.
- High selectivity and sensitivity
- Nitroreductase (NTR)-activated
- Visualizes acute lung injury (ALI) and its repair function
- Low detection limit of 54.8 ng/mL
- Suitable for monitoring and assessing response to sepsis-induced ALI
- Golgi-targetable probe
Medchemexpress LLC Urea, N-cyclopropyl-N'-[(3R)-1-[[5-(1-methylethyl)-1H-pyrazol-3-yl]carbonyl]-3-pyrrolidinyl | 3031476-73-7 | C15H23N5O2 | 25 MG
Urea, N-cyclopropyl-N'-[(3R)-1-[[5-(1-methylethyl)-1H-pyrazol-3-yl]carbonyl]-3-pyrrolidinyl | 3031476-73-7 | C15H23N5O2 | 25 MG
Medchemexpress LLC ODN 6016 sodium | DNA, d(T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G), sodium salt | 1 MG
ODN 6016 sodium is classified as a CpG-A oligonucleotide. This compound is known for its ability to induce the production of IFN-α. Researchers utilize ODN 6016 sodium in studies concerning immune disorders, particularly those involving immunodeficiency, such as conditions caused by HIV-1.
- Type: CpG-A oligonucleotide
- Function: Induces IFN-α production
- Research applications: Immune disorders, immunodeficiency (e.g., HIV-1-related)
- Sequence: T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G
Medchemexpress LLC EGFR-IN-69 | 2433837-65-9 | C31H37Cl2N7O3S | 1 ML
EGFR-IN-69 is a potent EGFR inhibitor designed for non-small-cell-lung-cancer (NSCLC) research. This compound demonstrates high purity and specific inhibitory activity against various EGFR mutants, including EGFRL858R/T790M/C797S, EGFRL858R/T790M, and EGFR19del/T790M/C797S.
- Potent EGFR inhibitor
- Suitable for non-small-cell-lung-cancer (NSCLC) research
- Purity of 99.58%
- Inhibits EGFRL858R/T790M/C797S with an IC50 of 4.3 nM
- Solid appearance, light yellow to yellow
- Soluble in DMSO at 12.5 mg/mL
- Molecular weight of 658.64
Medchemexpress LLC Bis(pinacolato)diborane | 73183-34-3 | 99.97% | C12H24B2O4 | 1 ML
Bis(pinacolato)diborane is an organoboron reagent that serves as a source of the [Bpin] moiety, known for its nucleophilic character. It is primarily used in the synthesis of various organoboranes, including organoboron compounds and arylboronates.
- Acts as a source of the Bpin moiety.
- Exhibits pronounced nucleophilic character.
- Utilized in synthesizing diverse organoboranes.
- Forms tetraborylated products with p-benzyne.
Medchemexpress LLC N,N'-Carbonyldiimidazole | 530-62-1 | 99.9% | C7H6N4O | 500 G
N,N'-Carbonyldiimidazole (1,1'-Carbonyldiimidazole) is a highly reactive carboxylating reagent. It activates hydroxyl groups to form reactive carbonyl groups and functions as a coupling agent and peptide synthesis reagent. In vitro, it mediates the conjugation of ovalbumin with magnetite nanoparticles for vaccine delivery.
- Highly reactive carboxylating reagent
- Activates hydroxyl groups to form reactive carbonyl groups
- Can be used as a coupling agent
- Functions as a peptide synthesis reagent
- Mediates conjugation of ovalbuminn with magnetite nanoparticles for vaccine delivery in vitro
Medchemexpress LLC (S)-2-aminobutyramide hydrochloride | 7682-20-4 | MFCD00136565 | ≥98.0% | C4H11ClN2O | 100 G
(S)-2-aminobutyramide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is also an organic amide, mainly used as a pharmaceutical intermediate.
- Biochemical reagent
- Can be used as a biological material or organic compound for life science related research
- Organic amide
- Mainly used as a pharmaceutical intermediate
Medchemexpress LLC 2-Hydrazinobenzothiazole | 615-21-4 | 99.95% | C7H7N3S | 100 G
This compound, 2-Hydrazinobenzothiazole, is a potent IDO1 inhibitor with an IC50 of 8 μM. It interacts with the IDO1 haem through hydrazine and has potential for immune system related diseases research. It is supplied with a purity of 99.95%.
- Potent IDO1 inhibitor (IC50 of 8 μM)
- Interacts with IDO1 haem via hydrazine
- Suitable for immune system related diseases research
- Purity of 99.95%
- Solid appearance
- Molecular weight: 165.22
- Chemical formula: C7H7N3S
- CAS number: 615-21-4
Medchemexpress LLC Benzenemethanaminium, N,N,N-triethyl-, chloride | 56-37-1 | MFCD00011824 | ≥98.0% | 227.77 | C13H22ClN | 250g
Benzyltriethylammonium chloride is a quaternary ammonium salt commonly used as a phase transfer catalyst surfactant and stabilizer in various chemical reactions especially in organic synthesis Benzyltriethylammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another making it an important ingredient in a variety of industrial processes
Medchemexpress LLC 1-Tosylimidazole | 2232-08-8 | MFCD00005285 | 222.27 | 250 G
1-Tosylimidazole is a biochemical reagent widely utilized in life science research. It functions as both a biological material and an organic compound, essential for various laboratory applications.
- Appears as a white to off-white solid
- Purity greater than 99.75%
- Molecular formula C10H10N2O2S
- CAS number 2232-08-8
- Solubility in DMSO is 100 mg/mL
Medchemexpress LLC 2-bromo-3-methylpyridine | 3430-17-9 | 172.03 | 25 G
2-Bromo-3-methylpyridine is a heterocyclic intermediate of the halomethylpyridine family. It is utilized in the synthesis of platinum(IV) diazide complexes.
- Used in the synthesis of platinum(IV) diazide complexes
- For research use only
Medchemexpress LLC Glurate (4-Acetylbutyric acid) | 3128-06-1 | MFCD00004412 | 130.14 | 25 G
Glurate (4-Acetylbutyric acid) is an acylating agent. It plays a role in the development of antiviral compounds, specifically those targeting retroviruses such as herpes virus and HIV. It is also involved in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid.
- Acylating agent
- Used in the development of antiviral compounds targeting retroviruses (herpes virus, HIV)
- Utilized in the synthesis of acyclic nucleoside derivatives
- Utilized in the synthesis of 5-hydroxyhexanoic acid
Medchemexpress LLC ARD-2051 | 2632305-17-8 | 98.6% | 789.32 | 50 MG
ARD-2051 is a selective and orally active proteolysis-targeting chimera (PROTAC) degrader targeting the androgen receptor (AR). It effectively degrades AR protein with DC50 values of 0.6 nM in prostate cancer cell lines (LNCaP and VCaP) and shows significant anti-tumor activity in VCaP xenograft mouse models, making it suitable for prostate cancer research.
- Selective and orally active PROTAC degrader
- Targets the androgen receptor (AR)
- Induces AR protein degradation (DC50 of 0.6 nM in LNCaP and VCaP cells)
- Inhibits cell growth (IC50 of 12.8 nM in LNCaP, 10.2 nM in VCaP)
- Suppresses expression of the AR-regulated gene KLK3
- Demonstrates anti-tumor activity in VCaP xenograft mice models
Medchemexpress LLC PA-915 (PAC1R antagonist 1) | 2305204-24-2 | 99.2% | 372.81 | 1 ML
PA-915 (PAC1R antagonist 1), also known as compound 3d, is a potent and orally active antagonist of the PAC1 receptor. It can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP)- and nerve injury-induced allodynia.
- Potent and orally active antagonist
- Inhibits pituitary adenylate cyclase-activating polypeptide (PACAP)
- Inhibits nerve injury-induced allodynia
- For research use only