L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective, and competitive antagonist of the oxytocin receptor (pA2=8.4). It exhibits high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).
- Orally bioavailable
- Non-blood-brain barrier penetrant
- Selective and competitive antagonist of the oxytocin receptor
- High affinity at oxytocin receptor (Ki=19 nM)
- High affinity at vasopressin V1a receptor (Ki=3.7 nM)
- Appears as a white to off-white solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 8.33 mg/mL (16.41 mM)